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Antioxidants, Volume 11, Issue 2

February 2022 - 259 articles

Cover Story: Průchová et al. used mitochondria isolated from wild-type and phospholipase A (iPLA) ablated mice to demonstrate that tert-butylhydroperoxide (TBHP) activates iPLA, with consequent liberation of fatty acids (FAs) and lysophospholipids. The released FAs interact with the adenine nucleotide translocase, leading to increased proton transport across the inner mitochondrial membrane and consequent attenuation of mitochondrial superoxide production. Detailed lipidomic analysis reveals a typical glycerophospholipid cleavage pattern for TBHP-activated iPLA and clarifies the role of iPLA in cardiolipin remodeling in the brain. Moreover, iPLA-KO mice were more sensitive to stimulation by pro-inflammatory lipopolysaccharide, supporting the antioxidant and anti-inflammatory role of iPLA in vivo. View this paper

Articles (259)

  • Article
  • Open Access
24 Citations
5,091 Views
20 Pages

Modulation of Antioxidant Defense in Farmed Rainbow Trout (Oncorhynchus mykiss) Fed with a Diet Supplemented by the Waste Derived from the Supercritical Fluid Extraction of Basil (Ocimum basilicum)

  • Gabriele Magara,
  • Marino Prearo,
  • Cristina Vercelli,
  • Raffaella Barbero,
  • Marco Micera,
  • Alfonso Botto,
  • Christian Caimi,
  • Barbara Caldaroni,
  • Cinzia Margherita Bertea and
  • Giuseppe Mannino
  • + 7 authors

18 February 2022

Phytotherapy is based on the use of plants to prevent or treat human and animal diseases. Recently, the use of essential oils and polyphenol-enriched extracts is also rapidly increasing in the aquaculture sector as a means of greater industrial and e...

  • Article
  • Open Access
10 Citations
9,078 Views
21 Pages

Effect of Dietary Grapes on Female C57BL6/J Mice Consuming a High-Fat Diet: Behavioral and Genetic Changes

  • Falguni Parande,
  • Asim Dave,
  • Eun-Jung Park,
  • Christopher McAllister and
  • John M. Pezzuto

18 February 2022

(1) Background: Adverse effects of a chronic high-fat diet (HFD) on murine behavior, cognition, and memory are well established. Polyphenols such as resveratrol, anthocyanins, and flavonoids, that are known for antioxidative and anti-inflammatory pro...

  • Review
  • Open Access
19 Citations
6,237 Views
19 Pages

Can Antioxidants Reduce the Toxicity of Bisphenol?

  • Wanda Mączka,
  • Małgorzata Grabarczyk and
  • Katarzyna Wińska

18 February 2022

BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the...

  • Article
  • Open Access
16 Citations
4,009 Views
20 Pages

17 February 2022

Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system. Currently, prescribed treatments are still unsatisfactory or have limited effectiveness. Camellia japonica leaves are known to have antioxidant and anti-inflammato...

  • Article
  • Open Access
13 Citations
4,503 Views
17 Pages

Protective Effect of Liposomal Epigallocatechin-Gallate in Experimental Gentamicin-Induced Hepatotoxicity

  • Adriana Elena Bulboacă,
  • Alina Silvia Porfire,
  • Vasile Rus,
  • Cristina Ariadna Nicula,
  • Corneliu Angelo Bulboacă and
  • Sorana D. Bolboacă

17 February 2022

Our study aimed to assess the effect of liposomal epigallocatechin-gallate (LEGCG) compared with epigallocatechin-gallate (EGCG) solution on hepatic toxicity induced by gentamicin (G) administration in rats. Five groups were evaluated, a control grou...

  • Article
  • Open Access
19 Citations
4,724 Views
17 Pages

Culture Conditions Affect Antioxidant Production, Metabolism and Related Biomarkers of the Microalgae Phaeodactylum tricornutum

  • Eleonora Curcuraci,
  • Simona Manuguerra,
  • Concetta Maria Messina,
  • Rosaria Arena,
  • Giuseppe Renda,
  • Theodora Ioannou,
  • Vito Amato,
  • Claire Hellio,
  • Francisco J. Barba and
  • Andrea Santulli

17 February 2022

Phaeodactylum tricornutum (Bacillariophyta) is a worldwide-distributed diatom with the ability to adapt and survive in different environmental habitats and nutrient-limited conditions. In this research, we investigated the growth performance, the tot...

  • Article
  • Open Access
10 Citations
3,926 Views
18 Pages

Phenylpropanoid Glycoside and Phenolic Acid Profiles and Biological Activities of Biomass Extracts from Different Types of Verbena officinalis Microshoot Cultures and Soil-Grown Plant

  • Paweł Kubica,
  • Adam Kokotkiewicz,
  • Magdalena Anna Malinowska,
  • Alicja Synowiec,
  • Małgorzata Gniewosz,
  • Shah Hussain,
  • Muhammad Yaqoob,
  • Günther K. Bonn,
  • Thomas Jakschitz and
  • Eman A. Mahmoud
  • + 5 authors

17 February 2022

Different types of microshoot cultures (agar, stationary liquid, agitated, and bioreactors) of Verbena officinalis were optimized for biomass growth and the production of phenylpropanoid glycosides and phenolic acids. Using ultra-high performance liq...

  • Review
  • Open Access
181 Citations
20,835 Views
36 Pages

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

  • Anushruti Ashok,
  • Syed Suhail Andrabi,
  • Saffar Mansoor,
  • Youzhi Kuang,
  • Brian K. Kwon and
  • Vinod Labhasetwar

17 February 2022

Free radicals are formed as a part of normal metabolic activities but are neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This redox balance is disrupted in certain neuropathophysiological condi...

  • Article
  • Open Access
24 Citations
4,534 Views
18 Pages

Coriolus Versicolor Downregulates TLR4/NF-κB Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect

  • Daniela Impellizzeri,
  • Roberta Fusco,
  • Tiziana Genovese,
  • Marika Cordaro,
  • Ramona D’Amico,
  • Angela Trovato Salinaro,
  • Maria Laura Ontario,
  • Sergio Modafferi,
  • Salvatore Cuzzocrea and
  • Rosanna Di Paola
  • + 2 authors

17 February 2022

Inflammatory bowel diseases (IBDs) are disorders characterized by chronic inflammation of the intestinal tract. The focus of the present study was to examine the effect of the fungus Coriolus versicolor (CV), underlining its correlation with Toll-lik...

  • Article
  • Open Access
39 Citations
4,808 Views
16 Pages

Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System

  • Ernestine Nicaise Djuidje,
  • Riccardo Barbari,
  • Anna Baldisserotto,
  • Elisa Durini,
  • Sabrina Sciabica,
  • Jan Balzarini,
  • Sandra Liekens,
  • Silvia Vertuani and
  • Stefano Manfredini

17 February 2022

Skin diseases often give multifactorial damages; therefore, the development of multifunctional compounds represents a suitable approach especially against disorders that are induced by oxidative stress. Thus, taking into account the successful result...

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Antioxidants - ISSN 2076-3921