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Brain Sciences, Volume 12, Issue 10

October 2022 - 156 articles

Cover Story: Many people with Alzheimer’s disease (AD) manifest a lack of motivation, i.e., apathy. A pathophysiological model of AD-related apathy proposed that this symptom may be a consequence of alterations in neural circuits involved in decision making and reward, encompassing primarily frontal, subcortical and brainstem areas. Previous studies have shown that apathy in AD may be primarily explained by functional alterations across salience and fronto-parietal networks, as well as by white matter damage, rather than an excess of grey matter neurodegeneration. In this study, we compared measures of both macro- and micro-structural white matter integrity between groups of patients with AD and healthy controls to support the hypothesis that structural disconnection may drive a lack of motivation. View this paper
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Articles (156)

  • Review
  • Open Access
2 Citations
3,033 Views
11 Pages

Advances on Cellular Clonotypic Immunity in Amyotrophic Lateral Sclerosis

  • Giuseppe Schirò,
  • Vincenzo Di Stefano,
  • Salvatore Iacono,
  • Antonino Lupica,
  • Filippo Brighina,
  • Roberto Monastero and
  • Carmela Rita Balistreri

20 October 2022

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease, characterized by the progressive degeneration of the upper and lower motor neurons in the cortex and spinal cord. Although the pathogenesis of ALS remains unclear, evidence concern...

  • Review
  • Open Access
6 Citations
4,712 Views
15 Pages

20 October 2022

Our ability to perform voluntary actions and make choices is shaped by the motivation from having control over the resulting effects (agency) and positive outcomes (reward). We offer an overview of distinct and common behavioral and neural signatures...

  • Review
  • Open Access
11 Citations
4,081 Views
14 Pages

Adenomyosis-Associated Ischemic Stroke: Pathophysiology, Detection and Management

  • Yuying Yan,
  • Xuening Zhang,
  • Di Zhong,
  • Anmo Wang,
  • Simiao Wu and
  • Bo Wu

20 October 2022

Female-specific risk factors for stroke have gradually received attention. The relationship between ischemic stroke and adenomyosis, a benign uterine disorder commonly present in parous women, is underrecognized. We aimed to provide an overview of th...

  • Article
  • Open Access
5 Citations
2,856 Views
19 Pages

20 October 2022

This study pursued two goals: (1) to establish range of motion (ROM) demand tiers (i.e., low, moderate, high) specific to the jaw (J), lower lip (LL), posterior tongue (PT), and anterior tongue (AT) for multisyllabic words based on the articulatory p...

  • Article
  • Open Access
4 Citations
4,234 Views
16 Pages

Odor Pleasantness Modulates Functional Connectivity in the Olfactory Hedonic Processing Network

  • Veit Frederik Kepler,
  • Manuel S. Seet,
  • Junji Hamano,
  • Mariana Saba,
  • Nitish V. Thakor,
  • Stavros I. Dimitriadis and
  • Andrei Dragomir

19 October 2022

Olfactory hedonic evaluation is the primary dimension of olfactory perception and thus central to our sense of smell. It involves complex interactions between brain regions associated with sensory, affective and reward processing. Despite a recent in...

  • Article
  • Open Access
5 Citations
3,467 Views
16 Pages

Adapted Behavioural Activation for Bipolar Depression: A Randomised Multiple Baseline Case Series

  • Kim Wright,
  • Mohammod Mostazir,
  • Ella Bailey,
  • Barnaby D. Dunn,
  • Heather O’Mahen,
  • Michaela Sibsey and
  • Zoe Thomas

19 October 2022

Behavioural Activation (BA) is associated with a substantial evidence base for treatment of acute unipolar depression, and has promise as an easily disseminable psychological intervention for bipolar depression. Using a randomised multiple baseline c...

  • Perspective
  • Open Access
1 Citations
2,122 Views
6 Pages

Prospective Evaluation of 3 T MRI Effect on Residual Hearing Function of Cochlea Implantees

  • Theda Eichler,
  • Ahmed Ibrahim,
  • Conrad Riemann,
  • Lars Uwe Scholtz,
  • Hans Björn Gehl,
  • Peter Goon,
  • Holger Sudhoff and
  • Ingo Todt

19 October 2022

Introduction: The approval process for MRI safety of implants includes physical observations and an experimental evaluation in artificial settings to simulate the in vivo effect. This contains the observation of temperature changes and artificial cur...

  • Review
  • Open Access
8 Citations
3,394 Views
17 Pages

Alzheimer’s Disease and SARS-CoV-2: Pathophysiological Analysis and Social Context

  • Genaro Gabriel Ortiz,
  • Irma E. Velázquez-Brizuela,
  • Genaro E. Ortiz-Velázquez,
  • María J. Ocampo-Alfaro,
  • Joel Salazar-Flores,
  • Daniela L. C. Delgado-Lara and
  • Erandis D. Torres-Sanchez

18 October 2022

The COVID-19 pandemic has proven to be a challenge for healthcare systems, especially in terms of the care of patients with Alzheimer’s disease (AD). Age is one of the major risk factors for severe forms of COVID-19, most probably due to the pr...

  • Article
  • Open Access
2 Citations
2,528 Views
30 Pages

18 October 2022

Source activity was extracted from resting-state magnetoencephalography data of 103 subjects aged 18–60 years. The directionality of information flow was computed from the regional time courses using delay symbolic transfer entropy and phase en...

  • Review
  • Open Access
16 Citations
5,775 Views
29 Pages

18 October 2022

Since depression remains a major public health issue there is a constant need for new and more efficient therapeutic strategies based on the mechanisms involved in the aetiology of depression. Thus, the pathogenic link between depression and inflamma...

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Brain Sci. - ISSN 2076-3425