Age-Related Neurodegenerative Diseases and Stroke
Stroke is one of the leading causes of adult disability and mortality worldwide, and has a huge socioeconomic impact.
The clinical course of stroke patients varies based on factors such as the type of stroke (ischemic or haemorrhagic), the localization of the brain insult, how fast and which treatments they have access to in the hyperacute phase, the setting of the in-hospital care in the acute phase, the rehabilitation resources and facilities and of course their individual characteristics (age, comorbidities and baseline functional status and stroke severity).
Although stroke is far more prevalent in the elderly population, a significant increase in younger adults is noted. This is mainly due to the increase in the prevalence of common cardiovascular risk factors such as hypertension, diabetes, hyperlipidaemia, obesity and lack of physical activity. However, stroke can also have other, more fascinating, aetiologies such as vasculitis, posterior reversible vasoconstriction syndrome, and genetic disorders (e.g. CADASIL).
Over the last few years, intra-arterial mechanical thrombectomy has been a game-changer in the management of patients with large vessel occlusion, the most severe form of acute ischaemic stroke. Although this has prevented a huge burden of residual disability, only a small proportion of ischemic stroke patients are eligible for the treatment. Consequently, there is a long list of key areas where we can still intervene in a patient’s long journey after a stroke to improve their outcomes.
Potential themes relevant to this Topic may include, but are not limited to, the following:
- Pre-hospital stroke recognition, triaging and management;
- Public education and awareness;
- Hyperacute ischaemic stroke management: intravenous thrombolysis and mechanical thrombectomy;
- Hyperacute spontaneous intracerebral haemorrhage management;
- Transient ischaemic attacks;
- Stroke mimics and stroke chameleons;
- Stroke aetiology and rare cases of stroke;
- Stroke imaging;
- Secondary stroke prevention;
- Stroke in the young population;
- In-hospital treatment (acute care and complications) and rehabilitation pathways;
- Novel working models in stroke (e.g. specialist nursing team involvement).
Currently, neurodegenerative disorders are one of the major public health problems that have become increasingly prevalent with an ageing population. Ageing itself is associated with changes in the Central Nervous System (CNS) that also appear in neurodegenerative diseases, but these changes are limited in healthy ageing. Despite advances in the research studies in the field, there are still many questions without answer. The first question relates to the major triggers that can cause accelerated brain ageing and promote neurodegenerative diseases, including age-related comorbidities. Many neurodegenerative diseases are discovered in the advanced stage; therefore, it is crucial to predict or identify the diseases onset/progression. In this light, the second question to be addressed is focused on potential biomarkers that can predict or identify the diseases onset at an early stage. Only few therapeutic options are available to treat the neurodegenerative diseases. There is still an urgent need to establish multimodal therapeutic protocols that limit the progression of the disease and improve quality of life.
Dr. Vasileios Papavasileiou
Dr. Ana Maria Bugă
- ischaemic stroke/TIA
- intracerebral haemorrhage
- stroke mimics & chameleons
- cardiovascular risk factors
- stroke treatment
- stroke prognosis
- stroke classification
- cerebral amyloid angiopathy
- carotid atherosclerosis
- neurodegenerative diseases
- age-related nutrition
|Journal Name||Impact Factor||CiteScore||Launched Year||First Decision (median)||APC|
Journal of Clinical Medicinejcm
|4.964||4.4||2012||18 Days||2600 CHF|
|2.948||2.7||1920||21.9 Days||1800 CHF|
|3.333||3.1||2011||14.9 Days||2000 CHF|
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