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Brain Sciences, Volume 12, Issue 10

October 2022 - 156 articles

Cover Story: Many people with Alzheimer’s disease (AD) manifest a lack of motivation, i.e., apathy. A pathophysiological model of AD-related apathy proposed that this symptom may be a consequence of alterations in neural circuits involved in decision making and reward, encompassing primarily frontal, subcortical and brainstem areas. Previous studies have shown that apathy in AD may be primarily explained by functional alterations across salience and fronto-parietal networks, as well as by white matter damage, rather than an excess of grey matter neurodegeneration. In this study, we compared measures of both macro- and micro-structural white matter integrity between groups of patients with AD and healthy controls to support the hypothesis that structural disconnection may drive a lack of motivation. View this paper
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Articles (156)

  • Article
  • Open Access
8 Citations
3,787 Views
14 Pages

The Effects of Temperature Management on Brain Microcirculation, Oxygenation and Metabolism

  • Katia Donadello,
  • Fuhong Su,
  • Filippo Annoni,
  • Sabino Scolletta,
  • Xinrong He,
  • Lorenzo Peluso,
  • Leonardo Gottin,
  • Enrico Polati,
  • Jacques Creteur and
  • Olivier De Witte
  • + 3 authors

21 October 2022

Purpose: Target temperature management (TTM) is often used in patients after cardiac arrest, but the effects of cooling on cerebral microcirculation, oxygenation and metabolism are poorly understood. We studied the time course of these variables in a...

  • Article
  • Open Access
7 Citations
3,767 Views
17 Pages

Profile of Service Use and Barriers to Access to Care among Brazilian Children and Adolescents with Autism Spectrum Disorders

  • Beatriz Araripe,
  • Cecilia Montiel-Nava,
  • Daniela Bordini,
  • Graccielle R. Cunha,
  • Gabriela Garrido,
  • Sebastián Cukier,
  • Ricardo Garcia,
  • Analia Rosoli,
  • Daniel Valdez and
  • Sheila C. Caetano
  • + 2 authors

21 October 2022

Delayed diagnosis and a lack of adequate care for people with autism spectrum disorder (ASD) are related to worse outcomes and quality of life. This study aimed to identify the profile of service use, barriers to access care, and factors related to t...

  • Article
  • Open Access
4 Citations
2,642 Views
16 Pages

21 October 2022

Action observation (AO) combined with motor imagery (MI) was verified as more effective in improving limb function than AO or MI alone, while the underlying mechanism of swallowing was ambiguous. The study aimed at exploring the efficacy of AO combin...

  • Article
  • Open Access
2,125 Views
10 Pages

21 October 2022

Background: The recent introduction of near-infrared spectroscopy has enabled the monitoring of cerebral blood flow in real-time. Previous studies have shown that blood flow velocity is a predictor of cardiovascular disease. We hypothesized that cere...

  • Article
  • Open Access
2,338 Views
14 Pages

21 October 2022

Sound-induced flash illusion (SiFI) is typical auditory dominance phenomenon in multisensory illusion. Although a number of studies have explored the SiFI in terms of age-related effects, the reasons for the enhanced SiFI in older adults are still co...

  • Article
  • Open Access
10 Citations
9,170 Views
16 Pages

21 October 2022

The menstrual cycle affects women’s emotional states, with estrogen and progesterone having predominant roles. However, it remains unclear whether the phases of the menstrual cycle also affect women’s motivational behaviors. In this study...

  • Article
  • Open Access
18 Citations
4,631 Views
22 Pages

21 October 2022

The principal reason for measuring mental workload is to quantify the cognitive cost of performing tasks to predict human performance. Unfortunately, a method for assessing mental workload that has general applicability does not exist yet. This is du...

  • Article
  • Open Access
5 Citations
2,960 Views
16 Pages

20 October 2022

Purpose: The effect of scinderin (SCIN) on cancer progression has been studied, but its role in glioma remains unknown. This study describes the value of SCIN for the diagnosis, prognosis, and treatment of glioma. Methods: The expression of SCIN was...

  • Article
  • Open Access
10 Citations
3,178 Views
9 Pages

Investigating p62 Concentrations in Cerebrospinal Fluid of Patients with Dementia: A Potential Autophagy Biomarker In Vivo?

  • Elisa Rubino,
  • Silvia Boschi,
  • Fausto Roveta,
  • Andrea Marcinnò,
  • Aurora Cermelli,
  • Cristina Borghese,
  • Maria Claudia Vigliani and
  • Innocenzo Rainero

20 October 2022

Several studies have revealed defects in autophagy in neurodegenerative disorders including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). SQSTM1/p62 plays a key role in the autophagic machinery and may serve as a marker for autoph...

  • Feature Paper
  • Article
  • Open Access
9 Citations
3,994 Views
16 Pages

20 October 2022

Multi-site resting-state functional magnetic resonance imaging (rs-fMRI) data can facilitate learning-based approaches to train reliable models on more data. However, significant data heterogeneity between imaging sites, caused by different scanners...

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Brain Sci. - ISSN 2076-3425