2026 October - 99 articles
Patients with acute right heart failure or pulmonary hypertension require cautious resuscitation because the right ventricle is highly preload-sensitive and has a narrow therapeutic window; both hypovolemia and volume overload may worsen hemodynamics...
Objective: The aim of this study is to examine associations between sleep-related medication use at the first inpatient fall and recurrent falls, focusing on drug classes and concurrent use of multiple classes. Methods: We conducted a single-center r...
Background/Objectives: Adequate reproductive health knowledge and preconception preparedness may support informed health-related decisions during pregnancy and before conception. Health literacy may influence the ability to access, understand, and us...
The absence of detectable flow on duplex ultrasound after venous ablation may correspond to different tissue states. This mechanistic narrative review examines histopathological and immunohistochemical responses after thermal, chemical, mechanochemic...
Background: Primary Health Care plays an important role in the provision and coordination of palliative care in many healthcare contexts. Education and training of healthcare professionals are relevant strategies to support the delivery of quality pa...
Background/Objectives: In breast cancer patients with limited nodal burden, sentinel lymph node biopsy (SLNB) alone, without axillary lymph node dissection (ALND), has shown non-inferior survival. However, it remains unclear how many SLNs should be h...
Background: Maternal obesity is associated with pregnancy complications and adverse perinatal outcomes, although observational associations may be influenced by confounding, exposure ascertainment, and missing data. This study investigated associatio...
Background: Transthoracic echocardiography (TTE) is the first-line imaging modality in neonates and infants with congenital heart disease (CHD), whereas cardiovascular computed tomography (CCT) is generally reserved for selected questions that remain...
Background/Objectives: Dupilumab blocks the interleukin-4 receptor alpha (IL-4Rα) subunit, thereby inhibiting IL-4- and IL-13-mediated signaling, and is an effective treatment for severe chronic rhinosinusitis with nasal polyps (CRSwNP). This s...
Background: Postoperative sepsis and related infectious complications remain major causes of morbidity after abdominal surgery. Artificial intelligence (AI) and machine learning (ML) models may support earlier risk stratification, but their generaliz...
Background: Appendiceal epithelial lesions are rare and heterogeneous. Evidence regarding vascular endothelial growth factor A (VEGF-A) expression in localized appendiceal lesions is limited. We compared VEGF-A immunoreactivity across diagnostic subt...
Background/Objectives: Uterus-preserving management of placenta accreta spectrum (PAS) is increasingly reported, but preservation rates are difficult to interpret without considering disease severity and maternal morbidity. We aimed to estimate short...
Background: Low anterior resection syndrome (LARS) and lower urinary tract symptoms (LUTS) are common after restorative rectal cancer surgery, but whether their postoperative severity is associated after accounting for relevant clinical, anatomical,...
Background/Objectives: OFF episodes in Parkinson’s disease (PD) include motor and non-motor manifestations, but their resolution after on-demand therapy may not be synchronous. We examined within-patient temporal dynamics of motor and non-motor...
Background/Objectives: To analyse trends in online information-seeking behaviour for five major cancers in Hungary, compare them with global trends, and assess changes during the COVID-19 pandemic, cancer-related awareness campaigns, and major cancer...
Candida auris (also termed Candidozyma auris) (C. auris) is an emerging healthcare-associated yeast that has become a major concern because of its persistence in hospitals, frequent misidentification, multidrug resistance, and ability to cause outbre...
Background/Objectives: Non-medical anabolic-androgenic steroid (AAS) use has been associated with adverse cardiac remodelling, but the magnitude of excess all-cause mortality and the cardiac phenotype of former users remain incompletely defined. Meth...
Background/Objectives: Salivary-gland biopsy is central to Sjögren’s disease (SjD) assessment, but conventional measures incompletely capture glandular heterogeneity. This systematic review evaluated artificial intelligence (AI)/machine le...
Breast cancer is the most frequent type of cancer in women and accounts for 11.6% of new cancer cases worldwide and 6.9% of cancer-related deaths. Breast surgery has evolved over time from radical mastectomy toward a preference for breast-conserving...
Background: Rapid screening methods reflecting the metabolic profile of urine are promising for assessing the risk of decreased renal function in children with obstructive uropathies. The aim of this pilot study was to evaluate the applicability of a...
Background: Methyltransferase-like 26 (METTL26) is a poorly characterized member of the METTL family that has been included in previous pan-cancer analyses, but its disease-specific clinical and molecular relevance in head and neck squamous cell carc...
Background/Objectives: Acute abdominal pain in children younger than five years is a diagnostic challenge because acute appendicitis and acute enteritis share overlapping clinical features, and delayed recognition of appendicitis increases the risk o...
Breast arterial calcification (BAC) is a manifestation of medial arterial calcification frequently detected incidentally on screening mammography. Increasing evidence suggests that BAC may also serve as a marker of cardiovascular risk. This narrative...
Background/Objectives: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with axicabtagene ciloleucel (axi-cel) improves outcomes in relapsed/refractory large B-cell lymphoma (LBCL), but many patients relapse despite retained CD19 expression....
Background/Objectives: Bromelain-based enzymatic debridement (NexoBrid®) is an established tissue-preserving alternative to tangential excision in deep partial-thickness burns. Its clinical efficacy is supported by randomised trials, but its syst...
Background/Objectives: The 2024 WHO guidelines incorporated the APRI index into treatment decisions for chronic hepatitis B, with thresholds of >0.5 for significant fibrosis and >1.0 for cirrhosis, because it can be computed when neither biopsy...
Background: Sickle cell disease (SCD) is a genetic disease where a mutation in beta-globin results in an increased hemoglobin S percentage (Hgb S%), which is responsible for the crisis. The aim of this study was to determine the impact of each unit p...
The gut microbiome has emerged as an important regulator of cancer biology, influencing carcinogenesis, treatment response, and therapy-related toxicity. This narrative review synthesizes current evidence on the mechanistic roles of the gut microbiot...
Background: Children with Down syndrome (DS) commonly present hypotonia, ligamentous laxity, and impaired postural control, which delay gross motor milestones and limit functional independence. Group-based, music-supported circuit kinetotherapy has b...
Background: Left atrial appendage occlusion (LAAO) is an alternative approach to stroke prevention in selected patients with non-valvular atrial fibrillation. This single-centre retrospective study describes device implantation, peri-procedural compl...
Background/Objectives: The upfront costs of angle-based minimally invasive glaucoma surgery (MIGS) maybe offset by reduced medication use and subsequent interventions. This systematic review synthesizes available cost-effectiveness analyses of angle-...
Background: The six-minute walk test (6MWT) in chronic obstructive pulmonary disease (COPD) may be interpreted using either an absolute walking-distance threshold or a percentage of the predicted distance, but these approaches are rarely compared wit...
Background: Re-Du-Ning (RDN) is a traditional Chinese medicine (TCM) formulation composed of Lonicera japonica, Gardenia jasminoides, and Artemisia annua. Previous in vitro studies have demonstrated that RDN suppresses pro-inflammatory cytokine relea...
Background: Autoimmune gastritis (AIG) and Helicobacter pylori gastritis are distinct etiologies of chronic gastritis, yet comparative data on their long-term progression remain limited. Objectives: We compared the evolution of precancerous gastric l...
Background/Objectives: Temporomandibular disorders (TMDs) are musculoskeletal conditions in which rehabilitation aims to reduce pain and restore mandibular mobility and function. We estimated the between-group effects of conservative and minimally in...
Background/Objectives: The Endothelial Activation and Stress Index (EASIX) is an easily accessible biomarker reflecting endothelial stress and has demonstrated prognostic value in several hematologic settings. However, its role in newly diagnosed mul...
Background/Objectives: Needle procedures cause acute pain through mechanical, chemical, sensory, and affective processes. We synthesized human and animal evidence and developed a framework spanning peripheral nociception, spinal/trigeminal modulation...
Background. Body mass index (BMI) remains the most widely used tool for obesity classification and cardiometabolic risk stratification. However, increasing evidence suggests that normal BMI does not necessarily reflect metabolic health, particularly...
Cervical cancer remains a major global health concern, causing substantial morbidity and mortality, particularly in low- and middle-income countries. Beyond its physical burden, patients frequently experience significant psychological distress, inclu...
Background/Objectives: Endothelial cell density (ECD) and vault height are essential safety metrics in implantable collamer lens (ICL) surgery, yet their reported decay rates vary. This study assessed short- and long-term changes in ECD and vault hei...
Background: Cataracts are a major cause of reversible visual impairment worldwide, particularly among older adults. Visual deterioration associated with cataracts may compromise spatial perception, postural control, and balance, thereby increasing th...
Background/Objectives: Reported infection rates during extracorporeal membrane oxygenation (ECMO) vary widely, partly because case definitions are applied inconsistently. We synthesized the prevalence and prognostic association of nosocomial and bloo...
Background/Objectives: Incretin-based therapies, including glucagon like peptide-1 receptor agonists (GLP-1 RAs) and glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RAs, are increasingly prescribed for obesity, leading to greater recognition...
Background: Telehealth has expanded remote access to ADHD care, yet a prescription issued remotely must still be filled at a pharmacy—and whether telehealth resolves these downstream fulfillment barriers remains unclear. Federal regulatory dist...
Background: Permanent postoperative hypoparathyroidism (p-HypoPT) is a major long-term complication of thyroid surgery; however, its incidence remains uncertain because reported rates are influenced by heterogeneous case mix and variable follow-up. W...
Introduction: Diabetic painful neuropathy (DPN) is one of the most common and debilitating complications of diabetes, substantially impairing the quality of life of patients. In the absence of disease-modifying therapies, treatment remains focused on...
Introduction: Coronary computed tomography angiography (CCTA) is a noninvasive test for suspected coronary artery disease (CAD), but the prognostic value of integrating plaque burden into CAD-RADS 2.0 has not been fully evaluated. We aimed to assess...
Background: This study assessed the association between serum ascorbic acid and zinc levels and depressive symptoms in young Ecuadorian adults. Methods: A case–control study was conducted among individuals aged 18–34 years. A total of 88...
Background/Objectives: The potential role of probiotics in the prevention and management of atopic dermatitis (AD) has received increasing attention. This study aimed to investigate factors associated with parent-reported AD in children aged 1–...
Background/Objectives: The rabbit bilateral common carotid artery ligation (BCCAL) model is utilized to simulate hemodynamically driven intracranial aneurysm formation. However, inconsistent reporting and heterogeneous endpoints obscure its baseline...
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