Emerging Arboviruses and Novel Viral Threats: Detection, Surveillance, and Mitigation Strategies

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 862

Special Issue Editor


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Guest Editor
Genomics Laboratory, Department of Biology, São Paulo State University (UNESP), São José do Rio Preto 15054-000, SP, Brazil
Interests: emerging viruses; arboviruses; surveillance; molecular epidemiology; serological epidemiology

Special Issue Information

Dear Colleagues,

This Special Issue, “Emerging Arboviruses and Novel Viral Threats: Detection, Surveillance, and Mitigation Strategies,” addresses the global challenge posed by novel viral threats and resurging arboviruses with public health implications. Factors such as climate change, urbanization, wildlife–human interactions, and increased human mobility are accelerating the spread and evolution of viral pathogens. It highlights approaches that integrate serological and molecular diagnostics, as well as epidemic and genomic surveillance, providing updates on advances in detecting, and monitoring of viral emergence.

The issue also seeks to explore innovative mitigation strategies, ranging from antiviral development and novel vaccine platforms to vector control, public health preparedness, and One Health-based interventions. By bringing together contributions from diverse fields of virology, this Special Issue provides a comprehensive perspective on the scientific tools necessary to reduce the impact of emerging and novel viral threats.

Dr. Vivaldo Gomes Da Costa
Guest Editor

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Keywords

  • emerging virus
  • diagnosis
  • surveillance
  • arbovirus
  • control

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Published Papers (1 paper)

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Research

15 pages, 3126 KB  
Article
Green Tea Catechins Significantly Reduce Zika Virus in RBCs Through Viral Inactivation
by Xipeng Yan, Jinlian Li, Xiaoqiong Duan, Limin Chen, Yujia Li and Chunhui Yang
Pathogens 2026, 15(3), 334; https://doi.org/10.3390/pathogens15030334 - 20 Mar 2026
Viewed by 589
Abstract
Background: Despite significant improvements in blood safety, the risk of transfusion-transmitted infections persists, particularly from emerging and re-emerging viruses. For red blood cell (RBC) products, this risk is exacerbated by the fact that there is no routine testing for many of these pathogens, [...] Read more.
Background: Despite significant improvements in blood safety, the risk of transfusion-transmitted infections persists, particularly from emerging and re-emerging viruses. For red blood cell (RBC) products, this risk is exacerbated by the fact that there is no routine testing for many of these pathogens, and effective, commercially available pathogen inactivation technologies specifically for RBCs are still lacking. This gap in the safety framework means that viruses capable of establishing an asymptomatic viremia—a characteristic of many arboviruses like Zika, dengue, and West Nile virus—present a tangible threat to the blood supply, highlighting the need for broad-spectrum countermeasures. Study Design and Methods: This study aims to investigate the antiviral activity of green tea extract (GTE) and its key catechins, epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), against ZIKV in both cellular models and red blood cell (RBC) products. In vitro antiviral activity was assessed using A549 cells treated with GTE (150 μg/mL) or purified EGCG/ECG (20 μM). Mechanistic studies focused on viral attachment inhibition. Additionally, ZIKV-spiked RBC products were co-incubated with GTE (300 μg/mL) for 1 h to evaluate virucidal effects. Erythrocyte integrity was confirmed via hemolysis assays. Results: Co-treatment with GTE or catechins suppressed ZIKV replication by ≥3.64 logs (p < 0.001) in A549 cells. GTE and catechins primarily inhibited viral attachment. In RBCs, GTE reduced viral infectivity by 99.99% (4-log reduction) without compromising erythrocyte membrane integrity or cellular viability. Furthermore, RBCs with added GTE demonstrated a lower hemolysis rate during storage for up to 60 days. Conclusions: GTE exhibits potent virucidal activity against ZIKV in blood matrices, highlighting its potential as a pathogen reduction agent to enhance transfusion safety. Further development of GTE-based additive solutions or technologies is warranted. Full article
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