Advanced Antimicrobial Agents: Combatting Multi-Drug Resistant Bacterial Infections

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 779

Special Issue Editor


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Guest Editor
Division of Environmental and Population Health Biosciences, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers University, Piscataway, NJ 08854, USA
Interests: antimicrobial technology development; antibiotic resistance; nanotechnology; bioaerosols
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Special Issue Information

Dear Colleagues,

Despite the advances in antibiotic development, infectious diseases continue to affect hundreds of millions of people each year with serious outcomes, impacting public health adversely. Incorrect prescription of antibiotics and their overuse have led to the dangerous rise in antibiotic resistance. The most alarming aspect of this is the rise in multi-drug-resistant (MDR) infections. Due to the interconnected nature of the modern economy, the MDR pathogens are spreading rapidly across the globe, causing pandemics. Thus, there is a vital need to develop novel advanced antimicrobial agents for inactivating MDR pathogens.

Although this is an issue of vital importance to the field of public health, there is no focused effort in highlighting such research in the literature. In this Special Issue, we would like to highlight cutting edge research being carried out at the forefront of the battle against these MDR pathogens. Novel approaches such as nanotechnology, advanced pharmaceutical approaches, UV, and other such technologies are some research areas intended to be covered by this issue.

We look forward to featuring your exciting research in this field, which would be of great interest to the readers of the journal and the broad scientific community in general. Thank you.

Dr. Nachiket Vaze
Guest Editor

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Keywords

  • multi-drug resistance
  • antimicrobial susceptibility
  • nanoformulations
  • UV disinfection
  • antibiotic synergy

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Published Papers (1 paper)

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Review

33 pages, 1065 KiB  
Review
Disarming Staphylococcus aureus: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence
by Abdelaziz Touati, Nasir Adam Ibrahim and Takfarinas Idres
Pathogens 2025, 14(4), 386; https://doi.org/10.3390/pathogens14040386 - 15 Apr 2025
Viewed by 579
Abstract
Staphylococcus aureus is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, and immune evasion. This article explores innovative anti-virulence strategies to disarm S. aureus by targeting critical virulence factors without exerting bactericidal pressure. Key [...] Read more.
Staphylococcus aureus is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, and immune evasion. This article explores innovative anti-virulence strategies to disarm S. aureus by targeting critical virulence factors without exerting bactericidal pressure. Key approaches include inhibiting adhesion and biofilm formation, neutralizing toxins, disrupting quorum sensing (e.g., Agr system inhibitors), and blocking iron acquisition pathways. Additionally, interventions targeting two-component regulatory systems are highlighted. While promising, challenges such as strain variability, biofilm resilience, pharmacokinetic limitations, and resistance evolution underscore the need for combination therapies and advanced formulations. Integrating anti-virulence strategies with traditional antibiotics and host-directed therapies offers a sustainable solution to combat multidrug-resistant S. aureus, particularly methicillin-resistant strains (MRSA), and mitigate the global public health crisis. Full article
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