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Pathogens, Volume 13, Issue 7

July 2024 - 85 articles

Cover Story: Tolerance enables bacteria to survive intermittent antibiotic exposure without an increase in antimicrobial susceptibility. In this study, we investigated the presence of tolerance to three antimicrobials, ceftriaxone, azithromycin and ciprofloxacin in clinical isolates of Neisseria gonorrhoeae. A total of 4 of the 62 clinical anorectal isolates and none of the urogenital isolates exhibited tolerance to azithromycin. Tolerance to ceftriaxone and ciprofloxacin was observed in eight and four isolates, respectively, with no difference between infection sites. Tolerance was also detected in 8 (K, M, N, O, P, U, V, W) out of the 14 WHO reference strains. This study identified ceftriaxone, azithromycin and ciprofloxacin tolerance in clinical and WHO reference N. gonorrhoeae isolates. Azithromycin tolerance was more common in anorectal than urogenital infections. View this paper
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Articles (85)

  • Review
  • Open Access
5 Citations
2,452 Views
17 Pages

Reptiles and amphibians are largely present in many environments, including domestic areas when they are kept as pet animals. They often harbor zoonotic pathogens, which can pose a serious risk of infection for humans, mainly immunocompromised indivi...

  • Communication
  • Open Access
1 Citations
1,512 Views
8 Pages

Bovine tuberculosis (bTB) continues to have significant economic and veterinary health impacts on cattle herds where the disease remains endemic. The continual tailoring of policies to address such maintenance requires an in-depth analysis of nationa...

  • Review
  • Open Access
3 Citations
6,444 Views
18 Pages

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

  • Yajna Ramphal,
  • Houriiyah Tegally,
  • James Emmanuel San,
  • Martina Larissa Reichmuth,
  • Marije Hofstra,
  • Eduan Wilkinson,
  • Cheryl Baxter,
  • CLIMADE Consortium,
  • Tulio de Oliveira and
  • Monika Moir

The Chikungunya virus (CHIKV) poses a significant global public health concern, especially in Africa. Since its first isolation in Tanzania in 1953, CHIKV has caused recurrent outbreaks, challenging healthcare systems in low-resource settings. Recent...

  • Article
  • Open Access
2 Citations
2,328 Views
13 Pages

Excreted/Secreted 15-kDa Proteins and Serine Protease Peptides from Haemonchus contortus Act as Immune-Response Enhancers in Lambs

  • René Camas-Pereyra,
  • Génesis Andrea Bautista-García,
  • Gustavo Pérez-Anzúrez,
  • Zaira Carolina Duran-Cortes,
  • David Emanuel Reyes-Guerrero,
  • Jocelyn Maza-Lopez,
  • Agustín Olmedo-Juárez and
  • María Eugenia López-Arellano

This study assessed the immunoprotective effect in lambs of a native excreted/secreted 15-kDa protein and two synthesised S28 peptides derived from the infective transitory larvae (xL3) and adult stages (AS) of Haemonchus contortus. Twenty-two Pelibu...

  • Article
  • Open Access
2 Citations
1,752 Views
10 Pages

Wolbachia Promotes an Anti-Angiogenic Response Using an In Vitro Model of Vascular Endothelial Cells in Relation to Heartworm Disease

  • Manuel Collado-Cuadrado,
  • Claudia Alarcón-Torrecillas,
  • Iván Rodríguez-Escolar,
  • Alfonso Balmori-de la Puente,
  • Elena Infante González-Mohino,
  • Miguel Pericacho and
  • Rodrigo Morchón

Heartworm disease caused by Dirofilaria immitis is a vector-borne zoonotic disease responsible for the infection of mainly domestic dogs and cats, or these are those for which the most data are known. Humans are an accidental host where a benign, asy...

  • Article
  • Open Access
1 Citations
2,982 Views
12 Pages

Comparison of Antiviral Immune Responses in Healthy Cats Induced by Two Immune Therapeutics

  • Petra Cerna,
  • Steven Dow,
  • William Wheat,
  • Lyndah Chow,
  • Jennifer Hawley and
  • Michael R. Lappin

Background: Effective immunotherapeutic agents for use in cats are needed to aid in the management of intractable viral diseases, including feline infectious peritonitis (FIP) infection. The objectives of this study were to compare two different immu...

  • Article
  • Open Access
2 Citations
1,723 Views
13 Pages

VP0 Myristoylation Is Essential for Senecavirus A Replication

  • Peiyu Xiao,
  • Liang Meng,
  • Xingyang Cui,
  • Xinran Liu,
  • Lei Qin,
  • Fandan Meng,
  • Xuehui Cai,
  • Dongni Kong,
  • Tongqing An and
  • Haiwei Wang

Many picornaviruses require the myristoylation of capsid proteins for viral replication. Myristoylation is a site-specific lipidation to the N-terminal G residue of viral proteins, which is catalyzed by the ubiquitous eukaryotic enzyme N-myristoyltra...

  • Review
  • Open Access
5 Citations
2,360 Views
10 Pages

Colpodella species are free-living protists phylogenetically related to apicomplexans. Colpodella sp. have been detected in human and animal tissues, as well as in ticks and biting flies. The trophozoite and cyst stages of Colpodella species can be d...

  • Article
  • Open Access
4 Citations
1,772 Views
11 Pages

Temporal and Serotypic Dynamics of Actinobacillus pleuropneumoniae in South African Porcine Populations: A Retrospective Study from 1985 to 2023

  • Emmanuel M. Seakamela,
  • Marijke M. Henton,
  • Annelize Jonker,
  • Prudence N. Kayoka-Kabongo and
  • Itumeleng Matle

Actinobacillus pleuropneumoniae is a major bacterial pathogen causing porcine pleuropneumoniae, which is a disease of notable economic impact and high fatality rates among pigs worldwide. It has been reported that 19 distinct serotypes of this bacter...

  • Article
  • Open Access
2,659 Views
14 Pages

Sociodemographic, Clinical, and Behavioral Factors Associated with Sexual Transmitted Infection among HIV-1 Positive Migrants in Portugal: Are There Differences between Sexes?

  • Mafalda N. S. Miranda,
  • Victor Pimentel,
  • Jacqueline Graça,
  • Sofia G. Seabra,
  • Cruz S. Sebastião,
  • António Diniz,
  • Domitília Faria,
  • Eugénio Teófilo,
  • Fausto Roxo and
  • Fernando Maltez
  • + 20 authors

Introduction: Sexually transmitted infections (STIs) continue to occur at high levels. According to the WHO, each year there are an estimated 374 million new infections with syphilis, gonorrhea, chlamydia, and trichomoniasis. STIs are associated with...

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Pathogens - ISSN 2076-0817