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Pathogens, Volume 11, Issue 1

January 2022 - 109 articles

Cover Story: Helicobacter pylori is a gastric pathogen that exploits multiple host signaling pathways, leading to the disruption of key cell functions. Two bacterial virulence factors play important roles in this scenario, the vacuolating cytotoxin VacA and the translocated effector protein CagA of the cag type IV secretion system (T4SS). Specifically, by overruling the phosphorylation status of cortactin, H. pylori alternates the activity of molecular interaction partners of this important protein, thereby manipulating the performance of cytoskeletal rearrangements, endosomal trafficking, and cell movement. Here, we found that cortactin is necessary for the effective induction of T4SS- and CagA-dependent AGS cell movement and elongation but is dispensable for VacA uptake and formation of VacA-dependent vacuole formation and cell apoptosis. View this paper.
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Articles (109)

  • Brief Report
  • Open Access
5 Citations
2,551 Views
8 Pages

Avian Bornaviruses in Wild Aquatic Birds of the Anseriformes Order in Poland

  • Edyta Świętoń,
  • Kamila Dziadek and
  • Krzysztof Śmietanka

15 January 2022

Bornaviruses are a diverse family of viruses infecting various hosts, including birds. Aquatic bird bornavirus 1 (ABBV-1) and aquatic bird bornavirus 2 (ABBV-2) have been found in wild waterfowl but data on their prevalence are scarce. To gain knowle...

  • Article
  • Open Access
15 Citations
3,402 Views
11 Pages

Genetic Characterization and Variation of African Swine Fever Virus China/GD/2019 Strain in Domestic Pigs

  • Xun Wang,
  • Xiaoying Wang,
  • Xiaoxiao Zhang,
  • Sheng He,
  • Yaosheng Chen,
  • Xiaohong Liu and
  • Chunhe Guo

14 January 2022

African swine fever (ASF) was first introduced into Northern China in 2018 and has spread through China since then. Here, we extracted the viral DNA from the blood samples from an ASF outbreak farm in Guangdong province, China and sequenced the whole...

  • Review
  • Open Access
1 Citations
2,266 Views
10 Pages

14 January 2022

Sepsis remains an important source of morbidity and mortality in children, despite the development of standardized care. In the last decades, there has been an increased interest in genetic and genomic approaches to early recognition and development...

  • Article
  • Open Access
25 Citations
4,216 Views
9 Pages

HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients

  • Maria Antonietta Manca,
  • Tatiana Solinas,
  • Elena Rita Simula,
  • Marta Noli,
  • Stefano Ruberto,
  • Massimo Madonia and
  • Leonardo A. Sechi

14 January 2022

A higher expression of human endogenous retroviruses (HERVs) has been associated with several malignancies, including prostate cancer, implying a possible use as a diagnostic or prognostic cancer biomarker. For this reason, we examined the humoral re...

  • Perspective
  • Open Access
25 Citations
5,384 Views
13 Pages

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

  • Anthony K. L. Leung,
  • Diane E. Griffin,
  • Jürgen Bosch and
  • Anthony R. Fehr

14 January 2022

Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonst...

  • Article
  • Open Access
6 Citations
2,852 Views
15 Pages

Effect of Female Sex Hormones on the Immune Response against Chlamydia abortus and on Protection Conferred by an Inactivated Experimental Vaccine in a Mouse Model

  • Laura Del Rio,
  • Antonio Murcia-Belmonte,
  • Antonio Julián Buendía,
  • Jose Antonio Navarro,
  • Nieves Ortega,
  • Daniel Alvarez,
  • Jesús Salinas and
  • María Rosa Caro

14 January 2022

Mice are valuable models extensively used to test vaccine candidates against Chlamydia abortus and to clarify immunopathological mechanisms of the bacteria. As this pathogen has the ability to reactivate during pregnancy, it is important to deepen th...

  • Article
  • Open Access
7 Citations
3,264 Views
16 Pages

Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria

  • Cyrine Bouabid,
  • Yoshiki Yamaryo-Botté,
  • Sameh Rabhi,
  • Haifa Bichiou,
  • Chaima Hkimi,
  • Wafa Bouglita,
  • Melek Chaouach,
  • Naouel Eddaikra,
  • Kais Ghedira and
  • Lamia Guizani-Tabbane
  • + 2 authors

14 January 2022

Leishmaniasis is a protozoal vector-borne disease that affects both humans and animals. In the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents and canids. Lipidomic approaches have allowed scientists to establis...

  • Article
  • Open Access
11 Citations
3,649 Views
11 Pages

13 January 2022

SCUBA divers are predisposed to otitis externa caused by Pseudomonas aeruginosa, which is becoming increasingly multi-drug resistant (MDR). The present work assessed the antibiotic resistance profiles of P. aeruginosa obtained from SCUBA divers and t...

  • Systematic Review
  • Open Access
22 Citations
7,888 Views
23 Pages

13 January 2022

Filth flies, cockroaches, and dung beetles have been close neighbors with humans and animals throughout our joint histories. However, these insects can also serve as vectors for many zoonotic enteric parasites (ZEPs). Zoonoses by ZEPs remain a paramo...

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Pathogens - ISSN 2076-0817Creative Common CC BY license