The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses
Abstract
:1. Introduction
2. Macrodomains Represent a Unique Target for Pathogens of Pandemic Potential
3. The Biochemistry of Macrodomains
4. Viral Macrodomains Are Critical for Viral Replication and Disease Pathogenesis
5. Viral Macrodomain Counteracts Host Antiviral Responses Mediated through PARPs
6. High Conservation of the Viral Macrodomain Indicates the Potential to Develop Broad Spectrum Antivirals
7. Structural and Biochemical Data Indicate Feasibility of Developing Macrodomain-Targeted Antivirals
8. High-Throughput Assays for Compound Screening
9. Conclusions
Funding
Acknowledgments
Conflicts of Interest
References
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Leung, A.K.L.; Griffin, D.E.; Bosch, J.; Fehr, A.R. The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses. Pathogens 2022, 11, 94. https://doi.org/10.3390/pathogens11010094
Leung AKL, Griffin DE, Bosch J, Fehr AR. The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses. Pathogens. 2022; 11(1):94. https://doi.org/10.3390/pathogens11010094
Chicago/Turabian StyleLeung, Anthony K. L., Diane E. Griffin, Jürgen Bosch, and Anthony R. Fehr. 2022. "The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses" Pathogens 11, no. 1: 94. https://doi.org/10.3390/pathogens11010094