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Journal of Personalized Medicine, Volume 13, Issue 10

October 2023 - 99 articles

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Cover Story: Patients with systemic sclerosis (SSc) are at risk of diaphragmatic dysfunction because of multiple factors. This study aimed to evaluate diaphragmatic function by assessing ultrasonic parameters—mobility, thickness, and thickening fraction, with regard to interstitial lung disease (SSc-ILD)—and to investigate associations between ultrasonic parameters and the Modified Medical Research Council (mMRC) dyspnea scale, lung function, modified Rodnan skin score (mRSS), and esophageal diameters upon HRCT. Patients with SSc-ILD had lower diaphragmatic mobility in deep breathing than patients without ILD. The results demonstrated negative correlations between diaphragmatic mobility and the mMRC scale, mRSS, esophageal diameters, and a positive correlation with lung function. View this paper

Articles (99)

  • Article
  • Open Access
8 Citations
4,279 Views
14 Pages

Assessing the Potential Risks of Digital Therapeutics (DTX): The DTX Risk Assessment Canvas

  • Kerstin Denecke,
  • Richard May,
  • Elia Gabarron and
  • Guillermo H. Lopez-Campos

23 October 2023

Motivation: Digital therapeutics (DTX), i.e., health interventions that are provided through digital means, are increasingly available for use; in some countries, physicians can even prescribe selected DTX following a reimbursement by health insuranc...

  • Review
  • Open Access
56 Citations
7,968 Views
15 Pages

Digital Twins in Healthcare: Methodological Challenges and Opportunities

  • Charles Meijer,
  • Hae-Won Uh and
  • Said el Bouhaddani

23 October 2023

One of the most promising advancements in healthcare is the application of digital twin technology, offering valuable applications in monitoring, diagnosis, and development of treatment strategies tailored to individual patients. Furthermore, digital...

  • Article
  • Open Access
2 Citations
2,977 Views
18 Pages

Breast Cancer Tissue Explants: An Approach to Develop Personalized Therapy in Public Health Services

  • Pilar Carranza-Rosales,
  • Daniel Valencia-Mercado,
  • Olga Esquivel-Hernández,
  • Manuel Ismael González-Geroniz,
  • José Inocente Bañuelos-García,
  • Ana Lilia Castruita-Ávila,
  • Mario Alberto Sánchez-Prieto,
  • Ezequiel Viveros-Valdez,
  • Javier Morán-Martínez and
  • Isaías Balderas-Rentería
  • + 2 authors

23 October 2023

Breast cancer is one of the main causes of death worldwide. Lately, there is great interest in developing methods that assess individual sensitivity and/or resistance of tumors to antineoplastics to provide personalized therapy for patients. In this...

  • Systematic Review
  • Open Access
5 Citations
3,693 Views
11 Pages

The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review

  • Jewel Kai Lin See,
  • Xinyao Liu,
  • Federica Canfora,
  • Caroline Moore,
  • Michael McCullough,
  • Tami Yap,
  • Rita Paolini and
  • Antonio Celentano

23 October 2023

Background: Micronutrients are vital for general and oral health, and their potential anti-cancer properties are documented. We explore beneficial vitamins for oral potentially malignant disorders (OPMDs) and oral cancer (OC), assessing the therapeut...

  • Review
  • Open Access
2 Citations
2,109 Views
13 Pages

Analysis of the Factors Intervening in the Prehospital Time in a Stroke Code

  • Álvaro Astasio-Picado,
  • Yolanda Cruz Chueca,
  • Miriam López-Sánchez,
  • Rocio Ruiz Lozano,
  • María Teresa González-Chapado and
  • Vanesa Ortega-Trancón

23 October 2023

Introduction: Strokes continue to be considered public health problems due to the great social and health impact they entail. They are the second cause of death in the world, with a high incidence and prevalence. They are time-dependent diseases, and...

  • Article
  • Open Access
7 Citations
2,419 Views
11 Pages

22 October 2023

This retrospective study aims to investigate the impact of cone-beam computed tomography (CBCT) viewing parameters such as contrast, slice thickness, and sharpness on the identification of the inferior alveolar nerve (IAC). A total of 25 CBCT scans,...

  • Article
  • Open Access
6 Citations
3,698 Views
13 Pages

Assessment of Surgical Accuracy in Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea: A Preliminary Analysis

  • Jean-Pierre T. F. Ho,
  • Ning Zhou,
  • Tom C. T. van Riet,
  • Ruud Schreurs,
  • Alfred G. Becking and
  • Jan de Lange

22 October 2023

This retrospective study aimed to: (1) investigate the surgical accuracy of maxillomandibular advancement (MMA) in obstructive sleep apnea (OSA) patients, with a specific focus on maxillary and mandibular advancement and counter-clockwise rotation an...

  • Article
  • Open Access
7 Citations
3,395 Views
17 Pages

The Benefits of a Comprehensive Cardiac Rehabilitation Program for Patients with Acute Coronary Syndrome: A Follow-Up Study

  • Laura Maria Craciun,
  • Florina Buleu,
  • Ana Maria Pah,
  • Marius Badalica-Petrescu,
  • Olivia Bodea,
  • Dana Emilia Man,
  • Oana Catalina Cosor,
  • Stela Iurciuc,
  • Simona Dragan and
  • Maria Rada

21 October 2023

Background and objectives: Secondary prevention after acute coronary syndrome (ACS) is essential to reduce cardiovascular mortality and hospital readmission, ensuring patients return to normal with an improved quality of life. Thus, we investigate th...

  • Article
  • Open Access
6 Citations
2,731 Views
12 Pages

Impact of Ultrasound–Assisted Method on Success Rate of Spinal Anesthesia Performed by Novice Trainees: A Retrospective Comparative Study

  • Antonio Coviello,
  • Carmine Iacovazzo,
  • Ilaria Piccione,
  • Concetta Posillipo,
  • Maria Silvia Barone,
  • Marilena Ianniello,
  • Andrea Uriel de Siena,
  • Dario Cirillo and
  • Maria Vargas

21 October 2023

In current practice, single-shot spinal anesthesia has traditionally been performed using the conventional surface-anatomic-Landmark-Guided technique. This “blind” technique has significant critical issues such as a high risk of complicat...

  • Article
  • Open Access
3 Citations
1,623 Views
14 Pages

The Influence of Different Irradiation Regimens on Inflammation and Vascularization in a Random-Pattern Flap Model

  • Wibke Müller-Seubert,
  • Patrick Ostermaier,
  • Raymund E. Horch,
  • Luitpold Distel,
  • Benjamin Frey,
  • Ramona Erber and
  • Andreas Arkudas

21 October 2023

Background: Irradiation plays an important role in the oncological treatment of various tumor entities. The aim of the study was to investigate the influence of different irradiation regimens on random-pattern flaps at the molecular and histopatholog...

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