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Diagnostics, Volume 8, Issue 3

September 2018 - 26 articles

Cover Story: The featured review in this issue of Diagnostics discusses current strategies in prostate cancer management—from diagnosis, therapy, and prognosis—while emphasizing the unmet need of stratifying patients for optimal care. Recent genomic, transcriptomic, and epigenomic analyses uncovering the spectrum of molecular heterogeneity in both localized and advanced disease, and the emergence of molecular signatures in pre-clinical and clinical settings underscore the plausibility of applying precision medicine in this cancer entity. View this paper.
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Articles (26)

  • Review
  • Open Access
12 Citations
7,154 Views
27 Pages

Promise and Implementation of Proteomic Prostate Cancer Biomarkers

  • Agnieszka Latosinska,
  • Maria Frantzi,
  • Axel S. Merseburger and
  • Harald Mischak

Prostate cancer is one of the most commonly diagnosed malignancy and the fifth leading cause of cancer mortality in men. Despite the broad use of prostate-specific antigen test that resulted in an increase in number of diagnosed cases, disease manage...

  • Article
  • Open Access
16 Citations
8,880 Views
18 Pages

Computer Aided Classification of Neuroblastoma Histological Images Using Scale Invariant Feature Transform with Feature Encoding

  • Soheila Gheisari,
  • Daniel R. Catchpoole,
  • Amanda Charlton,
  • Zsombor Melegh,
  • Elise Gradhand and
  • Paul J. Kennedy

Neuroblastoma is the most common extracranial solid malignancy in early childhood. Optimal management of neuroblastoma depends on many factors, including histopathological classification. Although histopathology study is considered the gold standard...

  • Article
  • Open Access
8 Citations
5,620 Views
15 Pages

A Preliminary Study of Contrast-Enhanced Ultrasound (CEUS) and Cytokine Expression Analysis (CEA) as Early Predictors for the Outcome of Tibial Non-Union Therapy

  • Patrick Haubruck,
  • Raban Heller,
  • Michael C. Tanner,
  • Volker Daniel,
  • Gerhard Schmidmaier,
  • Farhoud Bolourchi,
  • Arash Moghaddam and
  • Christian Fischer

The current study investigates if contrast-enhanced ultrasound (CEUS) or cytokine expression analysis (CEA) evaluating vascularization are capable of predicting the outcome of non-union therapy. Patients with tibial non-unions were surgically treated...

  • Article
  • Open Access
28 Citations
6,150 Views
8 Pages

Comparison of X-ray-Mammography and Planar UWB Microwave Imaging of the Breast: First Results from a Patient Study

  • Dennis Wörtge,
  • Jochen Moll,
  • Viktor Krozer,
  • Babak Bazrafshan,
  • Frank Hübner,
  • Clara Park and
  • Thomas J. Vogl

Hemispherical and cylindrical antenna arrays are widely used in radar-based and tomography-based microwave breast imaging systems. Based on the dielectric contrast between healthy and malignant tissue, a three-dimensional image could be formed to loc...

  • Article
  • Open Access
58 Citations
7,690 Views
38 Pages

On-Site Validation of a Microwave Breast Imaging System, before First Patient Study

  • Angie Fasoula,
  • Luc Duchesne,
  • Julio Daniel Gil Cano,
  • Peter Lawrence,
  • Guillaume Robin and
  • Jean-Gael Bernard

This paper presents the Wavelia microwave breast imaging system that has been recently installed at the Galway University Hospital, Ireland, for a first-in-human pilot clinical test. Microwave breast imaging has been extensively investigated over the...

  • Article
  • Open Access
16 Citations
6,299 Views
15 Pages

This paper studies how limited information in data acquired by a wideband microwave tomography (MWT) system can affect the quality of reconstructed images. Limitations can arise from experimental errors, mismatch between the system and its model in t...

  • Article
  • Open Access
20 Citations
8,367 Views
14 Pages

The study of resting-state functional brain networks is a powerful tool to understand the neurological bases of a variety of disorders such as Autism Spectrum Disorder (ASD). In this work, we have studied the differences in functional brain connectiv...

  • Article
  • Open Access
15 Citations
11,801 Views
7 Pages

A Novel Technique for Intraoral Ultrasound-Guided Aspiration of Peritonsillar Abscess

  • Tobias Todsen,
  • Mads Georg Stage and
  • Christoffer Holst Hahn

Peritonsillar abscess (PTA) is a common complication to acute tonsillitis. The treatment is drainage of the abscess, but many needle aspirations are unsuccessful due to a low diagnostic accuracy based on oral examination only. In this article, we des...

  • Article
  • Open Access
8 Citations
7,376 Views
15 Pages

Quantitative Analysis of Seven New Prostate Cancer Biomarkers and the Potential Future of the ‘Biomarker Laboratory’

  • Kevin Cao,
  • Callum Arthurs,
  • Ali Atta-ul,
  • Michael Millar,
  • Mariana Beltran,
  • Jochen Neuhaus,
  • Lars-Christian Horn,
  • Rui Henrique,
  • Aamir Ahmed and
  • Christopher Thrasivoulou

Prostate cancer is the third highest cause of male mortality in the developed world, with the burden of the disease increasing dramatically with demographic change. There are significant limitations to the current diagnostic regimens and no establish...

  • Article
  • Open Access
11 Citations
6,378 Views
9 Pages

It can be difficult for clinicians to accurately discriminate among histological classifications of breast lesions on ultrasonographic images. The purpose of this study was to develop a computer-aided diagnosis (CADx) scheme for determining histologi...

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Diagnostics - ISSN 2075-4418