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Life, Volume 13, Issue 8

August 2023 - 171 articles

Cover Story: Multidrug resistance (MDR) is a key contributor to treatment failure and mortality in cancer. Overexpression of ABC family drug transporters is a major MDR cause. Extracellular vesicles (EVs), tiny cell-released particles, mediate cell-to-cell communication, prompting phenotypic changes. This article reviews how EV-mediated communication regulates ABC transporters. MDR transfer between drug-resistant and drug-sensitive cells is found in various tumors. Direct transporter and mRNA transfer occurs between cells. EVs also transport regulatory proteins and RNAs inducing MDR. Conversely, drug-sensitive phenotype transfer via EVs happens. Interactions between non-tumor and tumor cells affecting MDR are discussed. Unexplored aspects and leveraging this knowledge for identifying actionable processes and molecules, advancing novel therapies, are highlighted. View this paper
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Articles (171)

  • Review
  • Open Access
17 Citations
5,283 Views
25 Pages

21 August 2023

The Sundarban is the world’s largest contiguous mangrove forest and stores around 26.62 Tg of blue carbon. The present study reviewed the factors causing a decline in its blue carbon content and poses a challenge in enhancing the carbon stock o...

  • Article
  • Open Access
2 Citations
2,364 Views
13 Pages

Identification and Functional Characterization of Mutation in FYCO1 in Families with Congenital Cataract

  • Muhammad Ikram Ullah,
  • Zaira Rehman,
  • Rubina Dad,
  • Abdullah Alsrhani,
  • Muhammad Shakil,
  • Heba Bassiony Ghanem,
  • Ayman Ali Mohammed Alameen,
  • Mohamed Farouk Elsadek,
  • Lienda Bashier Eltayeb and
  • Sajjad Ullah
  • + 1 author

21 August 2023

Congenital cataract (CC) causes a third of the cases of treatable childhood blindness worldwide. CC is a disorder of the crystalline lens which is established as clinically divergent and has complex heterogeneity. This study aimed to determine the ge...

  • Article
  • Open Access
3 Citations
2,239 Views
10 Pages

Role of Functional Neuroimaging with 123I-MIBG and 123I-FP-CIT in De Novo Parkinson’s Disease: A Multicenter Study

  • Maria Silvia De Feo,
  • Viviana Frantellizzi,
  • Nicoletta Locuratolo,
  • Arianna Di Rocco,
  • Alessio Farcomeni,
  • Caterina Pauletti,
  • Andrea Marongiu,
  • Julia Lazri,
  • Susanna Nuvoli and
  • Francesco Fattapposta
  • + 2 authors

21 August 2023

Background: Parkinson’s disease is a progressive neurodegenerative disorder, with incidence and prevalence rates of 8–18 per 100,000 people per year and 0.3–1%, respectively. As parkinsonian symptoms do not appear until approximatel...

  • Brief Report
  • Open Access
2,423 Views
9 Pages

Transcatheter Aortic Valve Implantation with the Portico Valve: 2-Year Outcomes of a Multicenter, Real-World Registry

  • Matthaios Didagelos,
  • Vlasis Ninios,
  • Charalampos Kakderis,
  • Lampros Lakkas,
  • Antonios Kouparanis,
  • Dimitrios Nikas,
  • Katerina K. Naka,
  • Aidonis Rammos,
  • Thomas Zegkos and
  • Vasileios Kamperidis
  • + 5 authors

21 August 2023

Introduction: The self-expanding, resheathable, repositionable transcatheter aortic heart valve Portico is being used successfully for transcatheter aortic valve implantation procedures (TAVI) in patients with severe aortic stenosis. The aim of this...

  • Review
  • Open Access
8 Citations
3,898 Views
19 Pages

Catheter Ablation for the Management of Atrial Fibrillation: An Update of the Literature

  • Shahana Hussain,
  • Catrin Sohrabi,
  • Rui Providencia,
  • Syed Ahsan and
  • Nikolaos Papageorgiou

21 August 2023

Catheter ablation has been shown to be more effective at maintaining sinus rhythm and improving quality of life when compared to antiarrhythmic drugs. Radiofrequency and cryoablation are two effective methods. However, catheter-only ablation strategi...

  • Review
  • Open Access
13 Citations
7,744 Views
20 Pages

Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review

  • Cynthia Imtiaz,
  • Muhammad Awais Farooqi,
  • Theophilus Bhatti,
  • Jooho Lee,
  • Ramsha Moin,
  • Chul Ung Kang and
  • Hafiz Muhammad Umer Farooqi

21 August 2023

Focused ultrasound (FUS) has emerged as a promising noninvasive therapeutic modality for treating atherosclerotic arterial disease. High-intensity focused ultrasound (HIFU), a noninvasive and precise modality that generates high temperatures at speci...

  • Review
  • Open Access
2 Citations
2,188 Views
47 Pages

21 August 2023

This article relates personal recollections and starts with the origin of electron microscopy in the sixties of the previous century at the University of Amsterdam. Novel fixation and embedding techniques marked the discovery of the internal bacteria...

  • Article
  • Open Access
2 Citations
3,054 Views
16 Pages

From In Silico Simulation between TGF-β Receptors and Quercetin to Clinical Insight of a Medical Device Containing Allium cepa: Its Efficacy and Tolerability on Post-Surgical Scars

  • Terenzio Cosio,
  • Gaetana Costanza,
  • Filadelfo Coniglione,
  • Alice Romeo,
  • Federico Iacovelli,
  • Laura Diluvio,
  • Emi Dika,
  • Ruslana Gaeta Shumak,
  • Piero Rossi and
  • Luca Bianchi
  • + 2 authors

21 August 2023

(1) Objective: Keloid and hypertrophic scars are a challenge in clinical management, causing functional and psychological discomfort. These pathological scars are caused by a proliferation of dermal tissue following skin injury. The TGF-β/Smad s...

  • Article
  • Open Access
4 Citations
2,740 Views
12 Pages

Evaluation of Carcass Attributes and Physical, Chemical, and Qualitative Characteristics of Breast Meat of Broiler Chickens Fed on Pulicaria jaubertii Powder

  • Hani H. Al-Baadani,
  • Ibrahim A. Alhidary,
  • Abdulrahman S. Alharthi,
  • Mahmoud M. Azzam,
  • Gamaleldin M. Suliman,
  • Mohammed A. Ahmed and
  • Akram A. Qasem

21 August 2023

Pulicaria jaubertii (PJ) is a medicinal plant used as a synthetic antioxidant and as a traditional medicine due to its bioactive compounds. The objective of this study was to investigate the effects of PJ on carcass traits and breast meat quality par...

  • Review
  • Open Access
14 Citations
4,452 Views
19 Pages

Inflammatory Bowel Disease as a Paradoxical Reaction to Anti-TNF-α Treatment—A Review

  • Ioana Ruxandra Mihai,
  • Alexandra Maria Burlui,
  • Ioana Irina Rezus,
  • Cătălina Mihai,
  • Luana Andreea Macovei,
  • Anca Cardoneanu,
  • Otilia Gavrilescu,
  • Mihaela Dranga and
  • Elena Rezus

20 August 2023

TNF-α inhibitors (TNFis) have revolutionized the treatment of certain chronic immune-mediated diseases, being widely and successfully used in rheumatic inflammatory diseases, and have also proved their efficacy in the treatment of inflammatory...

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Life - ISSN 2075-1729Creative Common CC BY license