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Life, Volume 13, Issue 8

August 2023 - 171 articles

Cover Story: Multidrug resistance (MDR) is a key contributor to treatment failure and mortality in cancer. Overexpression of ABC family drug transporters is a major MDR cause. Extracellular vesicles (EVs), tiny cell-released particles, mediate cell-to-cell communication, prompting phenotypic changes. This article reviews how EV-mediated communication regulates ABC transporters. MDR transfer between drug-resistant and drug-sensitive cells is found in various tumors. Direct transporter and mRNA transfer occurs between cells. EVs also transport regulatory proteins and RNAs inducing MDR. Conversely, drug-sensitive phenotype transfer via EVs happens. Interactions between non-tumor and tumor cells affecting MDR are discussed. Unexplored aspects and leveraging this knowledge for identifying actionable processes and molecules, advancing novel therapies, are highlighted. View this paper
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Articles (171)

  • Article
  • Open Access
7 Citations
2,869 Views
13 Pages

Association between Dapagliflozin, Cardiac Biomarkers and Cardiac Remodeling in Patients with Diabetes Mellitus and Heart Failure

  • Andrew Xanthopoulos,
  • Nikolaos Katsiadas,
  • Spyridon Skoularigkis,
  • Dimitrios E. Magouliotis,
  • Niki Skopeliti,
  • Sotirios Patsilinakos,
  • Alexandros Briasoulis,
  • Filippos Triposkiadis and
  • John Skoularigis

20 August 2023

Sodium–glucose cotransporter-2 inhibitors (SGLT2is) are a relatively new class of antidiabetic drugs that have shown favorable effects in heart failure (HF) patients, irrespective of the left ventricular ejection fraction (LVEF). Recent studies...

  • Article
  • Open Access
3 Citations
2,533 Views
15 Pages

20 August 2023

Background: The purpose of this study was to objectively evaluate visual discomfort using an eye tracker and aberrometer after a 21-min reading session on an iPad and an Ebook. Additionally, retinal changes were analyzed using optical coherence tomog...

  • Article
  • Open Access
2 Citations
2,498 Views
16 Pages

GABAB Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers

  • Ximena Delgado-Ramírez,
  • Nara S. Alvarado-Cervantes,
  • Natalie Jiménez-Barrios,
  • Guadalupe Raya-Tafolla,
  • Ricardo Felix,
  • Vladimir A. Martínez-Rojas and
  • Rodolfo Delgado-Lezama

20 August 2023

Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment. In thi...

  • Article
  • Open Access
1,795 Views
11 Pages

20 August 2023

The aim of this study was to evaluate the endocervical margin status according to transformation zone (TZ) and high-risk HPV (hr-HPV) subtype in specimens with cone length ≤ 10 mm versus > 10 mm to provide data for informed decision making and pat...

  • Article
  • Open Access
1 Citations
4,506 Views
12 Pages

19 August 2023

Background: Placenta accreta spectrum (PAS) is a clinical entity significantly increasing the risk of a peripartum hemorrhage. Various surgical methods have been described in the literature, which aim to reduce the risk of bleeding, although they oft...

  • Article
  • Open Access
2 Citations
1,989 Views
12 Pages

Cervical Impairments in Subjects with Chronic Migraine: An Observational Study

  • José Angel del-Blanco-Muñiz,
  • Daniel Martín-Vera,
  • Maria Dolores Sosa-Reina,
  • Alfonso Trinidad-Morales,
  • Marta de-la-Plaza-San-Frutos and
  • Alberto Sánchez-Sierra

18 August 2023

Objective: The aim of this investigation was to compare the thickness of the deep local muscles in the neck region, as well as local and widespread sensitivity and functionality, between individuals with migraine and healthy control subjects. Methods...

  • Systematic Review
  • Open Access
8 Citations
3,583 Views
14 Pages

18 August 2023

Serum adiponectin plays a vital role in various physiological processes, such as anti-inflammatory, anti-atherosclerotic, anti-apoptotic and pro-angiogenic activities. Any abnormalities in its concentration can lead to adverse health outcomes, partic...

  • Article
  • Open Access
5 Citations
3,402 Views
11 Pages

18 August 2023

(1) Background: Cerebrospinal fluid (CSF) leakage is one of the most common complications of microvascular decompression (MVD) surgery. Before fatal complications, such as intracranial infection, occur, early recognition and prompt treatment are esse...

  • Article
  • Open Access
1 Citations
2,170 Views
12 Pages

18 August 2023

Background: Haemorrhagic stroke, accounting for 10–20% of all strokes, often requires decompressive surgery as a life-saving measure for cases with massive oedema and raised intracranial pressure. This study was conducted to compare the demogra...

  • Case Report
  • Open Access
2 Citations
1,802 Views
12 Pages

Takotsubo Cardiomyopathy Occurring Simultaneously with Acute Myocardial Infarction

  • Ilija Srdanović,
  • Dragana Dabović,
  • Vladimir Ivanović,
  • Milenko Čanković,
  • Teodora Pantić,
  • Maja Stefanović,
  • Sonja Dimić,
  • Branislav Crnomarković,
  • Marija Bjelobrk and
  • Miljana Govedarica
  • + 1 author

18 August 2023

Introduction: Takotsubo cardiomyopathy (TCM) is a reversible form of cardiomyopathy characterized by transient regional systolic dysfunction of the left ventricle. Case outline: A 78-year-old woman was admitted to the general hospital due to acute in...

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Life - ISSN 2075-1729Creative Common CC BY license