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Life, Volume 12, Issue 8

2022 August - 186 articles

Cover Story: The microbiota is important for immune modulation, nutrient acquisition, vitamin production, and other aspects for long-term human health. Isolation can result in a loss of microbial diversity over time, accelerating disease progression on Earth, and potentially faster in space. Thus, maintaining a healthy microbiome during spaceflight has garnered recent consideration. Diet, lifestyle, and consumption of beneficial microbes can shape the microbiota, but replenishment from environmental exposure to microbes is important too. Probiotics, prebiotics, fermented foods, fecal microbiota transplantation (FMT), and novel microbiota modulation mechanisms with an impact on space-targeted health outcomes will be required to overcome the unique challenges faced in long-term space travel. View this paper
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Articles (186)

  • Article
  • Open Access
10 Citations
4,302 Views
22 Pages

Tff3 Deficiency Protects against Hepatic Fat Accumulation after Prolonged High-Fat Diet

  • Kate Šešelja,
  • Iva Bazina,
  • Milka Vrecl,
  • Jessica Welss and ,
  • Martin Schicht,
  • Martina Mihalj,
  • Vjekoslav Kopačin,
  • Friedrich Paulsen,
  • Tatjana Pirman and
  • Mirela Baus Lončar
  • + 5 authors+ 0 author

22 August 2022

Trefoil factor 3 (Tff3) protein is a small secretory protein expressed on various mucosal surfaces and is involved in proper mucosal function and recovery via various mechanisms, including immune response. However, Tff3 is also found in the bloodstre...

(This article belongs to the Collection Feature Papers in Animal Science)
  • Review
  • Open Access
45 Citations
16,632 Views
38 Pages

A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy

  • Nur Fadlin Saifulazmi,
  • Emelda Rosseleena Rohani,
  • Sarahani Harun,
  • Hamidun Bunawan and ,
  • Hamizah Shahirah Hamezah,
  • Nor Azlan Nor Muhammad,
  • Kamalrul Azlan Azizan,
  • Qamar Uddin Ahmed,
  • Sharida Fakurazi and
  • Murni Nazira Sarian
  • + 6 authors+ 1 author

22 August 2022

Exploration of the traditional medicinal plants is essential for drug discovery and development for various pharmacological targets. Various phytochemicals derived from medicinal plants were extensively studied for antiviral activity. This review aim...

  • Article
  • Open Access
9 Citations
3,369 Views
8 Pages

Multiglandular Parathyroid Disease

  • Grzegorz Kowalski,
  • Grzegorz Buła,
  • Adam Bednarczyk,
  • Agata Gawrychowska and
  • Jacek Gawrychowski

22 August 2022

Introduction: Multiglandular parathyroid disease (MGD) is an uncommon cause of primary hyperparathyroidism (pHPT) and has been reported in the literature in 8–33% of patients with pHPT. The aim of our study was to review the clinical characteri...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
5 Citations
3,600 Views
13 Pages

22 August 2022

The apical hook is formed by dicot seedlings to protect the tender shoot apical meristem during soil emergence. Regulated by many phytohormones, the apical hook has been taken as a model to study the crosstalk between individual signaling pathways. O...

(This article belongs to the Section Plant Science)
  • Article
  • Open Access
8 Citations
3,203 Views
19 Pages

Cyclosporine A Modulates LSP1 Protein Levels in Human B Cells to Attenuate B Cell Migration at Low O2 Levels

  • Shannon P. Hilchey,
  • Mukta G. Palshikar,
  • Eric S. Mendelson,
  • Shichen Shen and ,
  • Sailee Rasam,
  • Jason A. Emo,
  • Jun Qu,
  • Juilee Thakar and
  • Martin S. Zand
  • + 4 authors+ 0 author

22 August 2022

Coordinated migration of B cells within and between secondary lymphoid tissues is required for robust antibody responses to infection or vaccination. Secondary lymphoid tissues normally expose B cells to a low O2 (hypoxic) environment. Recently, we h...

(This article belongs to the Section Cell Biology and Tissue Engineering)
  • Article
  • Open Access
18 Citations
3,251 Views
28 Pages

The Application of Auxin-like Compounds Promotes Cold Acclimation in the Oilseed Rape Plant

  • Jurga Jankauskienė,
  • Rima Mockevičiūtė,
  • Virgilija Gavelienė,
  • Sigita Jurkonienė and
  • Nijolė Anisimovienė

22 August 2022

Cold is a major environmental key factor influencing plant growth, development, and productivity. Responses and adaption processes depend on plant physiological and biochemical modifications, first of all via the hormonal system. Indole-3-acetic acid...

(This article belongs to the Section Plant Science)
  • Reply
  • Open Access
3 Citations
1,839 Views
3 Pages

22 August 2022

Thank you for the opportunity to respond to the commentary [...]

(This article belongs to the Special Issue Healing after Trauma)
  • Comment
  • Open Access
1 Citations
1,771 Views
2 Pages

22 August 2022

We read the paper published by Oldrini, L.M. et al. (2022) [...]

(This article belongs to the Special Issue Healing after Trauma)
  • Article
  • Open Access
4 Citations
3,390 Views
17 Pages

Characterization of Bacterial Communities from the Surface and Adjacent Bottom Layers of Water in the Billings Reservoir

  • Marta Angela Marcondes,
  • Andrezza Nascimento,
  • Rodrigo Pessôa,
  • Jefferson Russo Victor and ,
  • Alberto José da Silva Duarte,
  • Patricia Bianca Clissa and
  • Sabri Saeed Sanabani
  • + 2 authors+ 0 author

22 August 2022

Here, we describe the bacterial diversity and physicochemical properties in freshwater samples from the surface and bottom layers of the Billings Reservoir, the largest open-air storage ecosystem in the São Paulo (Brazil) metropolitan area. Fo...

(This article belongs to the Section Biodiversity, Ecology and Evolution)
  • Article
  • Open Access
7 Citations
2,795 Views
8 Pages

Retinal Infarction: A Pilot Study on the Efficacy and Safety of Intravenous Thrombolysis and Underlying Aetiologies

  • Sonja Schönecker,
  • Johannes Wischmann,
  • Dennis C. Thunstedt,
  • Katharina Feil and ,
  • Marc J. Mackert,
  • Siegfried Priglinger and
  • Lars Kellert
  • + 2 authors+ 0 author

22 August 2022

Background: Treatment of non-arteritic central retinal artery occlusion is still inconsistent. Therefore, the current study aimed to evaluate the efficacy of intravenous thrombolysis (IVT) and describe the prevalence of co-occurring ischemic brain le...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
1 Citations
2,675 Views
11 Pages

Transcriptome Analyses Indicate Significant Association of Increased Non-Additive and Allele-Specific Gene Expression with Hybrid Weakness in Rice (Oryza sativa L.)

  • Yingheng Wang,
  • Jing Xia,
  • Likun Huang,
  • Qiang Lin and ,
  • Qiuhua Cai,
  • Hongguang Xie,
  • Wei He,
  • Yidong Wei,
  • Huaan Xie and
  • Jianfu Zhang
  • + 7 authors+ 2 authors

21 August 2022

The heterosis in hybrid rice is highly affected by the environment and hybrid weakness occurs frequently depending on the genotypes of the hybrid and its parents. Hybrid weakness was also observed in our field experiments on nine rice hybrids produce...

  • Article
  • Open Access
21 Citations
4,316 Views
11 Pages

21 August 2022

Clinical trials are conducted to evaluate the efficacy of new treatments. Clinical trials involving multiple treatments utilize the randomization of treatment assignments to enable the evaluation of treatment efficacies in an unbiased manner. Such ev...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
6 Citations
4,131 Views
14 Pages

Effects of a Combined Intradialytic Exercise Training Program and Music on Cardiac Autonomic Nervous System Activity in Hemodialysis Patients

  • Maria Mitsiou,
  • Eleftherios Dimitros,
  • Stefanos Roumeliotis,
  • Vassilios Liakopoulos and ,
  • Evangelia Kouidi and
  • Asterios Deligiannis
  • + 1 author+ 0 author

20 August 2022

This study aimed to examine the effect of an intradialytic exercise program in combination with music on heart rate variability (HRV) indices and functional capacity in patients on maintenance hemodialysis (HD). Methods: Forty HD patients were random...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
4 Citations
3,192 Views
11 Pages

Valvular Heart Disease following Anthracycline Therapy—Is It Time to Look beyond Ejection Fraction?

  • David Zahler,
  • Joshua H. Arnold,
  • Tali Bar-On,
  • Ari Raphael and ,
  • Shafik Khoury,
  • Zach Rozenbaum,
  • Shmuel Banai,
  • Yaron Arbel,
  • Yan Topilsky and
  • Michal Laufer-Perl
  • + 5 authors+ 0 author

20 August 2022

The association between anthracycline (ANT) and left ventricle (LV) dysfunction is well known; however, data regarding its direct effect on cardiac valve function is limited. We aimed to evaluate how ANT therapy affected valvular function in patients...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
31 Citations
5,780 Views
23 Pages

The Insulin-like Growth Factor System and Colorectal Cancer

  • Nikola Gligorijević,
  • Zorana Dobrijević,
  • Miloš Šunderić,
  • Dragana Robajac and ,
  • Danilo Četić,
  • Ana Penezić,
  • Goran Miljuš and
  • Olgica Nedić
  • + 3 authors+ 0 author

20 August 2022

Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including c...

(This article belongs to the Section Physiology and Pathology)
  • Article
  • Open Access
2 Citations
3,070 Views
11 Pages

19 August 2022

Introduction: High thrombus attenuation on CT has been suggested as a predictor of successful recanalization. It is as well speculated that thrombi of different density may be susceptible to different methods of mechanical thrombectomy. In this study...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
22 Citations
5,831 Views
23 Pages

Multiple Facets of Nitrogen: From Atmospheric Gas to Indispensable Agricultural Input

  • Nkulu Rolly Kabange,
  • So-Myeong Lee,
  • Dongjin Shin,
  • Ji-Yoon Lee and ,
  • Youngho Kwon,
  • Ju-Won Kang,
  • Jin-Kyung Cha,
  • Hyeonjin Park,
  • Simon Alibu and
  • Jong-Hee Lee
  • + 5 authors+ 0 author

19 August 2022

Nitrogen (N) is a gas and the fifth most abundant element naturally found in the atmosphere. N’s role in agriculture and plant metabolism has been widely investigated for decades, and extensive information regarding this subject is available. H...

(This article belongs to the Special Issue Rice Growth, Photosynthesis and Nitrogen Utilization)
  • Article
  • Open Access
6 Citations
3,485 Views
15 Pages

Circadian Rhythm Regulates Reactive Oxygen Species Production and Inhibits Al-Induced Programmed Cell Death in Peanut

  • Aaron Ntambiyukuri,
  • Xia Li,
  • Dong Xiao,
  • Aiqin Wang and ,
  • Jie Zhan and
  • Longfei He
  • + 1 author+ 0 author

19 August 2022

Peanut is among the most important oil crops in the world. In the southern part of China, peanut is highly produced; however, the arable land is acidic. In acidic soils, aluminum (Al) inhibits plant growth and development by changing the properties o...

(This article belongs to the Special Issue Plant Biotic and Abiotic Stresses)
  • Article
  • Open Access
7 Citations
6,045 Views
18 Pages

Dental and Periodontal Health in Acute Intermittent Porphyria

  • Elin Storjord,
  • Stella Airila-Månsson,
  • Katarzyna Karlsen,
  • Martin Madsen and ,
  • Jim André Dahl,
  • Anne Landsem,
  • Hilde Fure,
  • Judith Krey Ludviksen,
  • Johannes Østrem Fjøse and
  • Ole-Lars Brekke
  • + 9 authors+ 4 authors

19 August 2022

In the inherited metabolic disorder acute intermittent porphyria (AIP), high sugar intake prevents porphyric attacks due to the glucose effect and the following high insulin levels that may lower AIP disease activity. Insulin resistance is a known ri...

(This article belongs to the Special Issue Heme Metabolism and Porphyria)
  • Systematic Review
  • Open Access
25 Citations
3,402 Views
18 Pages

Potential Role of miR-196a and miR-196b as Prognostic Biomarkers of Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

  • Mario Dioguardi,
  • Stefania Cantore,
  • Diego Sovereto,
  • Lucia La Femina and ,
  • Giorgia Apollonia Caloro,
  • Francesca Spirito,
  • Salvatore Scacco,
  • Michele Di Cosola,
  • Lorenzo Lo Muzio and
  • Andrea Ballini
  • + 6 authors+ 1 author

19 August 2022

The etiopathogenetic mechanisms involving tumor genesis, including alteration of cell proliferation, apoptosis, invasion, migration, and death, may lead to alterations in microRNAs (miR) expression. The hypothesis is that with the presence in the lit...

(This article belongs to the Section Physiology and Pathology)
  • Review
  • Open Access
33 Citations
6,485 Views
12 Pages

Artificial Intelligence in Cryo-Electron Microscopy

  • Jeong Min Chung,
  • Clarissa L. Durie and
  • Jinseok Lee

19 August 2022

Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the structure of macromolecular complexes. The biological function of macromolecular complexes is inextricably tied to the flexibility of these complexes. Single particle...

(This article belongs to the Section Biochemistry, Biophysics and Computational Biology)
  • Review
  • Open Access
32 Citations
7,807 Views
24 Pages

19 August 2022

Biochemistry on Earth makes use of the key elements carbon, hydrogen, oxygen, nitrogen, phosphorus, and sulfur (or CHONPS). Chemically accessible molecules containing these key elements would presumably have been necessary for prebiotic chemistry and...

(This article belongs to the Special Issue Organic Chemical Evolution regarding the Origin(s) of Life)
  • Article
  • Open Access
7 Citations
6,223 Views
13 Pages

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

  • Il Hyeok Seo,
  • Jeongwoo Lee,
  • Dasom Na,
  • Hyunhye Kyung and ,
  • Jieun Yang,
  • Sangbong Lee,
  • Sang June Jeon,
  • Jae Won Choi,
  • Kyu Young Lee and
  • Se Hyun Kim
  • + 8 authors+ 3 authors

19 August 2022

Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed de...

(This article belongs to the Special Issue The Latest in Boron Neutron Capture Therapy Radiobiology)
  • Article
  • Open Access
24 Citations
6,363 Views
15 Pages

Did Usage of Mental Health Apps Change during COVID-19? A Comparative Study Based on an Objective Recording of Usage Data and Demographics

  • Maryam Aziz,
  • Aiman Erbad,
  • Mohamed Basel Almourad,
  • Majid Altuwairiqi and ,
  • John McAlaney and
  • Raian Ali
  • + 1 author+ 0 author

19 August 2022

This paper aims to objectively compare the use of mental health apps between the pre-COVID-19 and during COVID-19 periods and to study differences amongst the users of these apps based on age and gender. The study utilizes a dataset collected through...

(This article belongs to the Special Issue The Digital Health in the Pandemic Era)
  • Article
  • Open Access
2 Citations
2,734 Views
12 Pages

Forgivingness of an Anteromedially Positioned Small Locked Plate for High Tibial Osteotomy in Case of Overcorrection and Lateral Hinge Fracture

  • Sabrina Böhle,
  • Lars Bischoff,
  • Kristin Ehrenmann,
  • Frank Layher and ,
  • Klaus Sander,
  • Georg Matziolis and
  • Stefan Pietsch
  • + 2 authors+ 0 author

19 August 2022

High tibial osteotomy (HTO) represents a sensible treatment option for patients with moderate unicondylar osteoarthritis of the knee and extraarticular malalignment. The possibility of a continuously variable correction setting and a surgical approac...

(This article belongs to the Special Issue Orthopaedic Trauma and Reconstruction)
  • Review
  • Open Access
12 Citations
6,848 Views
21 Pages

The Biotics Family: Current Knowledge and Future Perspectives in Metabolic Diseases

  • Codrina-Madalina Palade,
  • Georgiana-Anca Vulpoi,
  • Radu-Alexandru Vulpoi,
  • Vasile Liviu Drug and ,
  • Oana-Bogdana Barboi and
  • Manuela Ciocoiu
  • + 1 author+ 0 author

19 August 2022

Globally, metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease pose a major public health threat. Many studies have confirmed the causal relationship between risk factors and the etiopathogenesis of these...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
15 Citations
3,383 Views
18 Pages

Microbial Diversity and Community Composition of Duodenum Microbiota of High and Low Egg-Yielding Taihang Chickens Identified Using 16S rRNA Amplicon Sequencing

  • Haiyin Han,
  • Yingjie Sun,
  • Yekai Fan,
  • Hui Zhang and ,
  • Junqi Yang,
  • Runqing Chi,
  • Yahui Gao,
  • Jiannan Liu,
  • Kaiyang Li and
  • Yufang Liu
  • + 6 authors+ 1 author

18 August 2022

The duodenum is an important digestive organ for poultry and houses a variety of microbes that help chickens to enhance nutrient absorption and improve production. To evaluate the characteristic of gut microbiome, duodenum content samples from 42-wee...

(This article belongs to the Section Animal Science)
  • Article
  • Open Access
7 Citations
4,251 Views
16 Pages

18 August 2022

S. chinensis is a typical monoecious plant, and the number and development of female flowers determines the yield of S. chinensis. Due to a lack of genetic information, the molecular mechanism of sex differentiation in S. chinensis remains unclear. I...

  • Review
  • Open Access
6 Citations
2,694 Views
21 Pages

17 August 2022

Incoherent neutron scattering (iNS) is one of the most powerful techniques to study the dynamical behavior of bio-macromolecules such as proteins and lipid molecules or whole cells. This technique has widely been used to elucidate the fundamental asp...

(This article belongs to the Special Issue Biomolecular Dynamics Explored by Incoherent Neutron Spectroscopy)
  • Article
  • Open Access
8 Citations
3,413 Views
18 Pages

Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices

  • Julia Hörnschemeyer,
  • Timo Kirschstein,
  • Gesine Reichart,
  • Christin Sasse and ,
  • Jakob Venus,
  • Anne Einsle,
  • Katrin Porath,
  • Michael Linnebacher,
  • Rüdiger Köhling and
  • Falko Lange
  • + 5 authors+ 0 author

17 August 2022

Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
26 Citations
3,995 Views
17 Pages

Analysis of Prevalence and Predictive Factors of Long-Lasting Olfactory and Gustatory Dysfunction in COVID-19 Patients

  • María A. Callejón-Leblic,
  • Daniel I. Martín-Jiménez,
  • Ramón Moreno-Luna,
  • Jose M. Palacios-Garcia and ,
  • Marta Alvarez-Cendrero,
  • Julissa A. Vizcarra-Melgar,
  • Carlos Fernandez-Velez,
  • Isabel M. Reyes-Tejero,
  • Juan Maza-Solano and
  • Serafín Sánchez-Gómez
  • + 9 authors+ 4 authors

17 August 2022

Background: Although smell and taste disorders are highly prevalent symptoms of COVID-19 infection, the predictive factors leading to long-lasting chemosensory dysfunction are still poorly understood. Methods: 102 out of 421 (24.2%) mildly symptomati...

(This article belongs to the Special Issue Olfactory and Gustatory Dysfunctions in COVID‐19 Patients)
  • Article
  • Open Access
4 Citations
3,171 Views
14 Pages

17 August 2022

Plants release a variety of volatiles and herbivore-induced plant volatiles (HIPVs) after being damaged by herbivorous insects, which play multiple roles in the interactions with other plants and insects. Agasicles hygrophila Selman and Vogt (Coleopt...

(This article belongs to the Special Issue Advances in Plant Defensive Biochemical Activity)
  • Review
  • Open Access
174 Citations
19,939 Views
41 Pages

African Swine Fever Virus: A Review

  • Zhaoyao Li,
  • Wenxian Chen,
  • Zilong Qiu,
  • Yuwan Li and ,
  • Jindai Fan,
  • Keke Wu,
  • Xiaowen Li,
  • Mingqiu Zhao,
  • Hongxing Ding and
  • Jinding Chen
  • + 6 authors+ 1 author

17 August 2022

African swine fever (ASF) is a viral disease with a high fatality rate in both domestic pigs and wild boars. ASF has greatly challenged pig-raising countries and also negatively impacted regional and national trade of pork products. To date, ASF has...

(This article belongs to the Section Microbiology)
  • Systematic Review
  • Open Access
43 Citations
7,796 Views
16 Pages

The Impact of eHealth Interventions on the Improvement of Self-Care in Chronic Patients: An Overview of Systematic Reviews

  • Erika Renzi,
  • Valentina Baccolini,
  • Giuseppe Migliara,
  • Corrado De Vito and ,
  • Giulia Gasperini,
  • Angelo Cianciulli,
  • Carolina Marzuillo,
  • Paolo Villari and
  • Azzurra Massimi
  • + 4 authors+ 0 author

17 August 2022

Promoting self-care is one of the most promising strategies for managing chronic conditions. This overview aimed to investigate the effectiveness of eHealth interventions at improving self-care in patients with type-2 diabetes mellitus, cardiovascula...

(This article belongs to the Special Issue The Digital Health in the Pandemic Era)
  • Review
  • Open Access
66 Citations
9,096 Views
16 Pages

The Delivery of mRNA Vaccines for Therapeutics

  • Nitika,
  • Jiao Wei and
  • Ai-Min Hui

17 August 2022

mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, de...

(This article belongs to the Section Medical Research)
  • Communication
  • Open Access
2 Citations
2,349 Views
8 Pages

Improvements in Plasma Tumor Necrosis Factor-Alpha Levels after a Weight-Loss Lifestyle Intervention in Patients with Obstructive Sleep Apnea

  • Michael Georgoulis,
  • Nikos Yiannakouris,
  • Roxane Tenta,
  • Ioanna Kechribari and ,
  • Kallirroi Lamprou,
  • Emmanouil Vagiakis and
  • Meropi D. Kontogianni
  • + 2 authors+ 0 author

17 August 2022

Obstructive sleep apnea (OSA) and systemic inflammation typically coexist within a vicious cycle. This study aimed at exploring the effectiveness of a weight-loss lifestyle intervention in reducing plasma tumor necrosis factor-alpha (TNF-a), a well-e...

(This article belongs to the Special Issue Obstructive Sleep Apnea (OSA))
  • Technical Note
  • Open Access
12 Citations
3,844 Views
8 Pages

Laparoscopic Laser Speckle Contrast Imaging Can Visualize Anastomotic Perfusion: A Demonstration in a Porcine Model

  • Aurelia Wildeboer,
  • Wido Heeman,
  • Arne van der Bilt,
  • Christiaan Hoff and ,
  • Joost Calon,
  • E. Christiaan Boerma,
  • Mahdi Al-Taher and
  • Nicole Bouvy
  • + 3 authors+ 0 author

16 August 2022

Background: Intestinal resection causes inevitable vascular damage, which cannot always be seen during an intraoperative clinical assessment of local intestinal perfusion. If left unaltered, impaired perfusion can lead to complications, such as anast...

(This article belongs to the Special Issue Recent Advances and Applications of Image-Guided Surgery)
  • Article
  • Open Access
9 Citations
5,066 Views
12 Pages

Astragalus membranaceus Extract Prevents Calcium Oxalate Crystallization and Extends Lifespan in a Drosophila Urolithiasis Model

  • Szu-Ju Chen,
  • Sunderiya Dalanbaatar,
  • Huey-Yi Chen,
  • Shih-Jing Wang and ,
  • Wei-Yong Lin,
  • Po-Len Liu,
  • Ming-Yen Tsai,
  • Der-Cherng Chen,
  • Yung-Hsiang Chen and
  • Wen-Chi Chen
  • + 5 authors+ 0 author

16 August 2022

Approximately 1 in 20 people develops kidney stones at some point in their life. Although the surgical removal of stones is common, the recurrence rate remains high and it is therefore important to prevent the occurrence of kidney stones. We chose As...

(This article belongs to the Collection The Role of Bioactive Natural Compounds in the Treatment of Diseases)
  • Article
  • Open Access
2 Citations
2,759 Views
9 Pages

16 August 2022

The properties of recombinant human gastric lipase produced in Arabidopsis thaliana roots have been investigated with the goal of determining the potential of the enzyme. This enzyme is stably bound to roots and can be extracted using a buffer at pH...

(This article belongs to the Special Issue Plants as a Promising Biofactory for Bioactive Compounds)
  • Article
  • Open Access
4 Citations
2,800 Views
11 Pages

Unmasking the ‘Asymptomatic’ COVID-19: A Nose Question

  • Andrea Mazzatenta,
  • Anna Berardi,
  • Gabriele Alessandro Novarria and
  • Giampiero Neri

16 August 2022

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has high infectivity, often masked by asymptomatic carriers, which allows it to spread rapidly and become a pandemic. Attempts to slow the pandemic at this stage depend on the...

(This article belongs to the Special Issue Olfactory and Gustatory Dysfunctions in COVID‐19 Patients)
  • Article
  • Open Access
19 Citations
3,934 Views
17 Pages

Anthocyanin Accumulation and Molecular Analysis of Correlated Genes by Metabolomics and Transcriptomics in Sister Line Apple Cultivars

  • Caiyun Shi,
  • Li Liu,
  • Zhifeng Wei,
  • Junwei Liu and ,
  • Ming Li,
  • Zhenli Yan and
  • Dengtao Gao
  • + 2 authors+ 0 author

16 August 2022

Red coloration in apples, an important quality trait, is primarily attributed to the accumulation of anthocyanins. Centuries of breeding have produced a wide variety of apples with different levels of anthocyanins in response to genetic and environme...

  • Article
  • Open Access
4 Citations
4,375 Views
10 Pages

16 August 2022

Immature oocytes are retrieved and matured through in vitro maturation (IVM). Maturation, fertilization rates, and embryo development via IVM are all lower than those found in vitro fertilization (IVF) cycles. We investigated the effects of oncostati...

(This article belongs to the Special Issue Early Career Stars in Physiology and Pathology)
  • Article
  • Open Access
10 Citations
3,739 Views
13 Pages

Dl-3-n-Butylphthalide Reduced Neuroinflammation by Inhibiting Inflammasome in Microglia in Mice after Middle Cerebral Artery Occlusion

  • Mengdi Liu,
  • Haoran Zheng,
  • Ze Liu,
  • Yiyan Guo and ,
  • Shuhong Wang,
  • Yaohui Tang,
  • Hengli Tian,
  • Zhijun Zhang and
  • Guoyuan Yang
  • + 4 authors+ 0 author

16 August 2022

The inflammatory response is one of the key events in cerebral ischemia, causing secondary brain injury and neuronal death. Studies have shown that the NLRP3 inflammasome is a key factor in initiating the inflammatory response and that Dl-3-n-butylph...

(This article belongs to the Section Medical Research)
  • Review
  • Open Access
11 Citations
5,401 Views
11 Pages

16 August 2022

The SARS-CoV-2 pandemic, reported for the first time at the end of 2019 in the city of Wuhan (China), has spread worldwide in three years; it lead to the infection of more than 500 million people and about six million dead. SARS-CoV-2 has proved to b...

(This article belongs to the Section Biochemistry, Biophysics and Computational Biology)
  • Article
  • Open Access
6 Citations
3,004 Views
10 Pages

Herbal Vitamin C Prevents DNA Oxidation and Modifies the Metabolomic Water Profile of Tilapia (Oreochromis spp.)

  • Moisés Villanueva,
  • Guillermo Espinosa-Reyes,
  • Rogelio Flores-Ramirez,
  • Angel Natanael Rojas-Velazquez and ,
  • Juan Carlos García López,
  • Anayeli Vazquez-Valladolid,
  • José Alejandro Roque-Jimenez,
  • German D. Mendoza-Martinez,
  • Pedro A. Hernandez-Garcia and
  • Héctor A. Lee-Rangel
  • + 7 authors+ 2 authors

16 August 2022

This experiment aimed to evaluate the effects of herbal vitamin C at different levels on tilapia (Oreochromis spp.) growth, potential DNA damage, and the metabolomic profile of water effluent. Forty-five tilapias were housed in separate plastic tanks...

(This article belongs to the Special Issue Natural Substances in Nutrition and Health of Animals)
  • Article
  • Open Access
11 Citations
8,556 Views
18 Pages

Nandrolone Decanoate and Swimming Affects Cardiodynamic and Morphometric Parameters in the Isolated Rat Heart

  • Jasmina Sretenovic,
  • Vladimir Zivkovic,
  • Ivan Srejovic,
  • Suzana Pantovic and ,
  • Jovana Joksimovic Jovic,
  • Maja Nikolic,
  • Tamara Nikolic Turnic,
  • Maja Savic,
  • Maja Jevdjevic and
  • Vladimir Jakovljevic
  • + 7 authors+ 2 authors

16 August 2022

(1) Background: The aim of this study was to show the effects of swimming and nandrolone administration on cardiodynamic and morphometric parameters of the isolated rat heart. (2) The study included 72 Wistar rats, divided into three groups, schedule...

  • Article
  • Open Access
17 Citations
4,056 Views
14 Pages

Association of NT-proBNP and hs-cTnT with Imaging Markers of Diastolic Dysfunction and Focal Myocardial Fibrosis in Hypertrophic Cardiomyopathy

  • Céleste Chevalier,
  • Miriam Wendner,
  • Anna Suling,
  • Ersin Cavus and ,
  • Kai Muellerleile,
  • Gunnar Lund,
  • Paulus Kirchhof and
  • Monica Patten
  • + 3 authors+ 0 author

16 August 2022

Serum biomarkers such as N-terminal prohormone of the brain natriuretic peptide (NT-proBNP) and cardiac troponins are elevated in patients with hypertrophic cardiomyopathy (HCM). At present, it is not clear if these markers are associated with distin...

(This article belongs to the Section Medical Research)
  • Article
  • Open Access
22 Citations
3,343 Views
13 Pages

The Role of the Precuneus in Human Spatial Updating in a Real Environment Setting—A cTBS Study

  • Milos Dordevic,
  • Sonja Hoelzer,
  • Augusta Russo,
  • José C. García Alanis and
  • Notger G. Müller

15 August 2022

As we move through an environment, we update positions of our body relative to other objects, even when some objects temporarily or permanently leave our field of view—this ability is termed egocentric spatial updating and plays an important ro...

(This article belongs to the Section Physiology and Pathology)

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Life - ISSN 2075-1729