You are currently viewing a new version of our website. To view the old version click .

Life, Volume 12, Issue 9

September 2022 - 169 articles

Cover Story: Cutaneous melanoma (CM) is responsible for most skin cancer-related deaths worldwide. Its origin is closely linked to the accumulation of UV-induced somatic mutations in melanocytes present in normal skin, nevi or dysplastic nevi. Mutations in TP53, NOTCH and FAT1 are common in normal skin, while mutations in BRAF and NRAS and in BRAF, TP53, CDKN2A, PTEN and RAS are characteristic of nevi and dysplastic nevi, respectively. However, a higher mutational burden on cancer-driving genes is required to convert normal melanocytes into malignant ones, and boost their progression towards more advanced stages. Mutations in BRAF, NRAS, KIT or NF1 are distinctive of early stages of CM, while CM progression to invasive stages is associated with mutations in TP53, PTEN, CDKN2A and TERT. Metastatic processes also include the dysregulation of genomic integrity. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (169)

  • Article
  • Open Access
3 Citations
3,019 Views
14 Pages

Effects of Secretoneurin and Gonadotropin-Releasing Hormone Agonist on the Spawning of Captive Greater Amberjack (Seriola dumerili)

  • Song Yanlong,
  • Jiang Yinjun,
  • Chen Ji,
  • Tao Binbin,
  • Xu Wen,
  • Huang Yang,
  • Li Guangli,
  • Chunhua Zhu and
  • Hu Wei

19 September 2022

The greater amberjack (Seriola dumerili), a pelagic marine species with a global distribution, has considerable worldwide potential as an aquaculture species. However, difficulties have been encountered in inducing spontaneous spawning in cultured fi...

  • Systematic Review
  • Open Access
3 Citations
3,432 Views
31 Pages

Identification of Suitable Drug Combinations for Treating COVID-19 Using a Novel Machine Learning Approach: The RAIN Method

  • Aliakbar Kiaei,
  • Nader Salari,
  • Mahnaz Boush,
  • Kamran Mansouri,
  • Amin Hosseinian-Far,
  • Hooman Ghasemi and
  • Masoud Mohammadi

19 September 2022

COVID-19 affects several human genes, each with its own p-value. The combination of drugs associated with these genes with small p-values may lead to an estimation of the combined p-value between COVID-19 and some drug combinations, thereby increasin...

  • Review
  • Open Access
18 Citations
5,906 Views
18 Pages

19 September 2022

The formation of gas vesicles has been investigated in bacteria and haloarchaea for more than 50 years. These air-filled nanostructures allow cells to stay at a certain height optimal for growth in their watery environment. Several gvp genes are invo...

  • Article
  • Open Access
16 Citations
2,785 Views
14 Pages

Exogenous Nitric Oxide and Silicon Applications Alleviate Water Stress in Apricots

  • Asuman Gundogdu Bakır,
  • Ibrahim Bolat,
  • Kubra Korkmaz,
  • Md. Mahadi Hasan and
  • Ozkan Kaya

19 September 2022

Many plants confront several environmental stresses including heat, water stress, drought, salinity and high-metal concentrations that are crucial in defining plant productivity at different stages of their life cycle. Nitric oxide (NO) and Silicon (...

  • Article
  • Open Access
7 Citations
2,665 Views
21 Pages

19 September 2022

Late embryogenesis abundant (LEA) proteins comprise a diverse superfamily involved in plant development and stress responses. This study presents a first genome-wide analysis of LEA genes in papaya (Carica papaya L., Caricaceae), an economically impo...

  • Article
  • Open Access
12 Citations
3,882 Views
18 Pages

Study on Cytotoxic and Genotoxic Potential of Bulgarian Rosa damascena Mill. and Rosa alba L. Hydrosols—In Vivo and In Vitro

  • Tsvetelina Gerasimova,
  • Gabriele Jovtchev,
  • Svetla Gateva,
  • Margarita Topashka-Ancheva,
  • Alexander Stankov,
  • Tsveta Angelova,
  • Ana Dobreva and
  • Milka Mileva

19 September 2022

The Rosa alba L. and Rosa damascena Mill. growing in Bulgaria are known for their extremely fine essential oil and valuable hydrosols. Irrespectively of its wide use in human life, little research exists on the cytotoxic and genotoxic activity of the...

  • Article
  • Open Access
5 Citations
4,080 Views
9 Pages

Cordyceps militaris Inhibited Angiotensin-Converting Enzyme through Molecular Interaction between Cordycepin and ACE C-Domain

  • Mónica A. Valdez-Solana,
  • Iván A. Corral-Guerrero,
  • Alfredo Téllez-Valencia,
  • Claudia Avitia-Domínguez,
  • Jorge A. Meza-Velázquez,
  • Atahualpa Guzmán de Casa and
  • Erick Sierra-Campos

19 September 2022

One of the most important therapeutic modalities for the management of hypertension is the inhibition of the angiotensin-converting enzyme (ACE). Cordyceps militaris has received substantial attention because to its therapeutic potential and biologic...

  • Article
  • Open Access
1 Citations
3,200 Views
17 Pages

Evaluation of the Antihyperglycemic and Antihyperlipidemic Activity of Saussurea hypoleuca Root in Alloxan-Induced Diabetes in Rat Model and Correlation to Its Major Secondary Metabolites

  • Numera Arshad,
  • Saiqa Ishtiaq,
  • Sairah Hafeez Kamran,
  • Muhammad Sajid-ur Rehman,
  • Shehla Akbar,
  • Saira Rehman,
  • Sarah Rehman,
  • Rawan H. Hareeri,
  • Sana A. Fadil and
  • Fadia S. Youssef
  • + 1 author

19 September 2022

Saussurea hypoleuca belongs to the family Asteraceae, which has previously shown hepatoprotective, anticancer, and antioxidant activity. This study aimed to evaluate the antihyperglycemic and antihyperlipidemic activity of its root methanol extract a...

  • Article
  • Open Access
5 Citations
3,287 Views
11 Pages

19 September 2022

(1) Background: Heart failure is a complex disease leading to functional disability. Cardiopulmonary exercise testing (CPET) is the gold standard in assessing aerobic capacity and formulating function-based prognostic stratification; however, patient...

  • Review
  • Open Access
4 Citations
3,387 Views
13 Pages

19 September 2022

Background. Many pathological conditions of both cardiovascular and non-cardiac origin in the course of their development cause damage to contractile cardiac muscle cells—cardiac myocytes (CMCs). One of the most sensitive and specific criteria...

of 17

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Life - ISSN 2075-1729