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Life, Volume 11, Issue 1

January 2021 - 72 articles

Cover Story: The endoplasmic reticulum is the protein synthesis factory of the cells. ER stress and unfolded protein response (UPR) are key cellular responses against misfolded protein accumulation in the ER. UPR maintains cellular balance and potentially is involved in pathogenesis of many diseases, including idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary (COPD) disease. Both genetic and environmental factors might be involved in UPR-induced IPF and COPD. UPR triggers programmed cell death (apoptosis), epithelial-to-mesenchymal transition (EMT), fibrosis and inflammation and potentially initiates IPF and COPD. Targeting different arms of UPR could be a future therapeutic approach for developing new therapies for IPF and COPD and bring hope to these patients for better quality of life. View this paper.
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Articles (72)

  • Article
  • Open Access
8 Citations
4,801 Views
16 Pages

Synthesis, Properties, and Biodegradability of Thermoplastic Elastomers Made from 2-Methyl-1,3-propanediol, Glutaric Acid and Lactide

  • Lamya Zahir,
  • Takumitsu Kida,
  • Ryo Tanaka,
  • Yuushou Nakayama,
  • Takeshi Shiono,
  • Norioki Kawasaki,
  • Naoko Yamano and
  • Atsuyoshi Nakayama

12 January 2021

An innovative type of biodegradable thermoplastic elastomers with improved mechanical properties from very common and potentially renewable sources, poly(L-lactide)-b-poly(2-methyl-1,3-propylene glutarate)-b-poly(L-lactide) (PLA-b-PMPG-b-PLA)s, has b...

  • Article
  • Open Access
14 Citations
4,904 Views
13 Pages

12 January 2021

(1) Background: Future missions to potentially habitable places in the Solar System require biochemistry-independent methods for detecting potential alien life forms. The technology was not advanced enough for onboard machine analysis of microscopic...

  • Review
  • Open Access
43 Citations
7,714 Views
13 Pages

LDL-Cholesterol and Platelets: Insights into Their Interactions in Atherosclerosis

  • Aleksandra Gąsecka,
  • Sylwester Rogula,
  • Łukasz Szarpak and
  • Krzysztof J. Filipiak

11 January 2021

Atherosclerosis and its complications, including acute coronary syndromes, are the major cause of death worldwide. The two most important pathophysiological mechanisms underlying atherosclerosis include increased platelet activation and increased low...

  • Article
  • Open Access
3 Citations
2,879 Views
11 Pages

11 January 2021

Fig wasps are a group of insects (Hymenoptera: Chalcidoidea) that live in the compact syconia of fig trees (Moraceae: Ficus). Accurate classification and phylogenetic results are very important for studies of fig wasps, but the taxonomic statuses of...

  • Article
  • Open Access
6 Citations
2,654 Views
13 Pages

Shear Stress and RBC-NOS Serine1177 Phosphorylation in Humans: A Dose Response

  • Jarod T. Horobin,
  • Surendran Sabapathy,
  • Lennart Kuck and
  • Michael J. Simmonds

8 January 2021

Red blood cells (RBC) express a nitric oxide synthase isoform (RBC-NOS) that appears dependent on shear stress for Serine1177 phosphorylation. Whether this protein is equally activated by varied shears in the physiological range is less described. He...

  • Opinion
  • Open Access
27 Citations
3,989 Views
7 Pages

8 January 2021

Diverse pathologies (inflammation, tissues injuries, cancer, etc.) and physiological conditions (obesity, physical activity, etc.) induce the expression/secretion of the matricellular protein, secrete protein acidic and rich in cysteine (SPARC). SPAR...

  • Article
  • Open Access
50 Citations
5,172 Views
9 Pages

Quality-of-Life Impairment among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study of 1795 Patients

  • Piotr K. Krajewski,
  • Łukasz Matusiak,
  • Esther von Stebut,
  • Michael Schultheis,
  • Uwe Kirschner,
  • Georgios Nikolakis and
  • Jacek C. Szepietowski

8 January 2021

The chronic, inflammatory skin disorder hidradenitis suppurativa (HS) is associated well documented negative influences on patients’ quality of life (QoL). The aim of this study was to present more robust data on patients’ QoL impairment...

  • Article
  • Open Access
11 Citations
3,157 Views
13 Pages

Alterations of Nigral Dopamine Levels in Parkinson’s Disease after Environmental Enrichment and PACAP Treatment in Aging Rats

  • Adel Jungling,
  • Dora Reglodi,
  • Gabor Maasz,
  • Zita Zrinyi,
  • Janos Schmidt,
  • Adam Rivnyak,
  • Gabor Horvath,
  • Zsolt Pirger and
  • Andrea Tamas

8 January 2021

The neuroprotective effects of environmental enrichment and PACAP (pituitary adenylate cyclase-activating polypeptide) are well-described in Parkinson’s disease. The aim of our study is to investigate the beneficial effects of these factors in...

  • Hypothesis
  • Open Access
19 Citations
4,716 Views
11 Pages

7 January 2021

Our understanding of the mechanisms of microgravity perception and response in prokaryotes (Bacteria and Archaea) lag behind those which have been elucidated in eukaryotic organisms. In this hypothesis paper, we: (i) review how eukaryotic cells sense...

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Life - ISSN 2075-1729