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Genes, Volume 14, Issue 12

December 2023 - 129 articles

Cover Story: Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive heterotopic ossification, wherein soft connective tissues undergo pathological transformation into bone structures. This write-up offers a comprehensive overview of the contemporary understanding of FOP’s complex pathobiology, underscored by advances in molecular genetics and proteomic studies. We delve into targeted therapy, spanning genetic therapeutics, enzymatic and transcriptional modulation, stem cell therapies, and innovative immunotherapies. We also highlight the intricate complexities surrounding clinical trial design for ultra-rare disorders like FOP, addressing fundamental statistical limitations, ethical conundrums, and methodological advancements essential for the success of interventional studies. View this paper
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Articles (129)

  • Article
  • Open Access
6 Citations
2,589 Views
18 Pages

14 December 2023

Litchi (Litchi chinensis Sonn.) is a tropical fruit originating from southern China that is currently cultivated in subtropical and tropical regions worldwide. Litchi anthracnose, caused by Colletotrichum fructicola, a dominant species of Collet...

  • Article
  • Open Access
3 Citations
2,244 Views
14 Pages

RNA-Sequencing Analysis Revealed Genes Associated with Sweet Potato (Ipomoea batatas (L.) Lam.) Responses to Stem Rot during Different Infection Stages

  • Chen Li,
  • Liang Zhang,
  • Honghu Ji,
  • Weihan Song,
  • Ziyu Zhong,
  • Meiqiao Jiang,
  • Yungang Zhang,
  • Qiang Li,
  • Linrun Cheng and
  • Meng Kou

14 December 2023

The sweet potato, which is an important tuber crop in China, is susceptible to a variety of pathogens and insect pests during cultivation and production. Stem rot is a common sweet potato disease that seriously affects tuber yield and quality. Unfort...

  • Review
  • Open Access
4 Citations
2,171 Views
15 Pages

14 December 2023

Seeds provide nutrients for the embryo and allow for dormancy in stressed environments to better adapt the plant to its environment. In addition, seeds are an essential source of food for human survival and are the basis for the formation of food pro...

  • Case Report
  • Open Access
1 Citations
2,757 Views
10 Pages

14 December 2023

Cornelia de Lange syndrome is a genetic and clinically heterogeneous entity, caused by at least five genes. It is characterized by short stature, gestalt facies, microcephaly, neurodevelopmental disorders, and other anomalies. In this report, we pres...

  • Article
  • Open Access
11 Citations
3,384 Views
12 Pages

Newborn Screening for Spinal Muscular Atrophy: A 2.5-Year Experience in Hyogo Prefecture, Japan

  • Shoko Sonehara,
  • Ryosuke Bo,
  • Yoshinori Nambu,
  • Kiiko Iketani,
  • Tomoko Lee,
  • Hideki Shimomura,
  • Masaaki Ueda,
  • Yasuhiro Takeshima,
  • Kazumoto Iijima and
  • Kandai Nozu
  • + 2 authors

14 December 2023

Newborn screening (NBS) for spinal muscular atrophy (SMA) is necessary, as favorable outcomes can be achieved by treatment with disease-modifying drugs in early infancy. Although SMA-NBS has been initiated in Japan, its clinical results have not been...

  • Article
  • Open Access
2 Citations
3,371 Views
14 Pages

Development of Human Rhinovirus RNA Reference Material Using Digital PCR

  • Dong U Ju,
  • Dongju Park,
  • Il-Hwan Kim,
  • Seil Kim and
  • Hee Min Yoo

14 December 2023

The human rhinovirus (RV) is a positive-stranded RNA virus that causes respiratory tract diseases affecting both the upper and lower halves of the respiratory system. RV enhances its replication by concentrating RNA synthesis within a modified host m...

  • Article
  • Open Access
15 Citations
11,874 Views
20 Pages

The Genome of the Yellow Mealworm, Tenebrio molitor: It’s Bigger Than You Think

  • Brenda Oppert,
  • Aaron T. Dossey,
  • Fu-Chyun Chu,
  • Eva Šatović-Vukšić,
  • Miroslav Plohl,
  • Timothy P. L. Smith,
  • Sergey Koren,
  • Morgan L. Olmstead,
  • Dewey Leierer and
  • Gail Ragan
  • + 1 author

14 December 2023

Background: Insects are a sustainable source of protein for human food and animal feed. We present a genome assembly, CRISPR gene editing, and life stage-specific transcriptomes for the yellow mealworm, Tenebrio molitor, one of the most intensively f...

  • Article
  • Open Access
8 Citations
2,132 Views
15 Pages

Modification of Gene Expression of Tomato Plants through Foliar Flavonoid Application in Relation to Enhanced Growth

  • Alberto Martinez-Alonso,
  • Lucia Yepes-Molina,
  • Angel L. Guarnizo and
  • Micaela Carvajal

13 December 2023

The exogenous application of phenolic compounds is increasingly recognized as a valuable strategy for promoting growth and mitigating the adverse effects of abiotic stress. However, the biostimulant effect under optimal conditions has not been thorou...

  • Article
  • Open Access
5 Citations
3,534 Views
13 Pages

13 December 2023

Diabetes is characterized by persistently high blood glucose levels and severe complications and affects millions of people worldwide. In this study, we explored the epigenetic landscape of diabetes using data from the Korean Genome and Epidemiology...

  • Article
  • Open Access
4 Citations
2,453 Views
20 Pages

BnPLP1 Positively Regulates Flowering Time, Plant Height, and Main Inflorescence Length in Brassica napus

  • Ting Ding,
  • Lei Cai,
  • Yuqi He,
  • Yuanhong Li,
  • Entang Tian,
  • Qianhui Zhou,
  • Xufan Zhou,
  • Xiaodong Wang,
  • Kunjiang Yu and
  • Xinjie Shen

13 December 2023

Protein prenylation mediated by the Arabidopsis thaliana PLURIPETALA (AtPLP) gene plays a crucial role in plant growth, development, and environmental response by adding a 15-carbon farnesyl group or one to two 20-carbon geranylgeranyl grou...

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Genes - ISSN 2073-4425