DNA Damage and Repair in Microorganisms, Plants and Mammalian Systems

Dear Colleagues,

Maitaining genome integrity is important for the perpetuation of all life forms. Cells that are constantly subject to endogenous and exogenous mutagens instigate robust DNA damage response (DDR), while persistent DNA damage triggers cell senescence or apoptosis. Mounting evidence suggests that the disruption and dysregulation of DNA damage repair play a key role in survival and adaptation of pathogens, cancer, neurodegeneration, and aging, to name but a few. DNA damage repair, in particular the p53 pathway, also contributes to the success and selection of CRISPR-based genome editing. In this Special Issue of Genes, we welcome reviews, research articles, brief communications, and perspectives that will employ biochemical and biophysical technologies to address the mechanisms of genotoxins, DDR pathways, telomere maintenance, DNA replication fidelity, repetitive sequences and chromosome fragility, and mitochondrial genome integrity in both microorganisms and mammalian systems. Therapeutic interventions, ranging from small molecules to biologics, that target DDR pathways in human diseases are also of special interest.

Dr. Ioly Kotta-Loizou
Dr. Nan Zhang
Dr. Xin Wang
Guest Editors

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