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Genes, Volume 11, Issue 10

2020 October - 124 articles

Cover Story: Adaptation to changing environment is a growing challenge in the era of the “Anthropocene”, and populations capable of rapid adaptation to novel selection pressures are more likely to survive. The Caspian whipsnake (Dolichophis caspius) is a large-bodied, non-venomous colubrid and inhabits dry steppe and Mediterranean habitats, from Eastern Europe around the Caspian and Black Sea to the north-western edge of its distribution in Hungary. Applying ddRAD sequencing we investigated genetic diversity and adaptive evolution to local habitat types and identified 751 selected genotypes correlated with seven key climatic variables. We found that isothermality may have an important role in the distribution and adaptation of Caspian whipsnakes. View this paper
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Articles (124)

  • Article
  • Open Access
15 Citations
8,171 Views
18 Pages

GJB2 and GJB6 Genetic Variant Curation in an Argentinean Non-Syndromic Hearing-Impaired Cohort

  • Paula Buonfiglio,
  • Carlos D. Bruque,
  • Leonela Luce,
  • Florencia Giliberto,
  • Vanesa Lotersztein,
  • Sebastián Menazzi,
  • Bibiana Paoli,
  • Ana Belén Elgoyhen and
  • Viviana Dalamón

21 October 2020

Genetic variants in GJB2 and GJB6 genes are the most frequent causes of hereditary hearing loss among several deaf populations worldwide. Molecular diagnosis enables proper genetic counseling and medical prognosis to patients. In this study, we prese...

  • Article
  • Open Access
22 Citations
5,694 Views
20 Pages

21 October 2020

The genus Lactobacillus includes species that may inhabit different anatomical locations in the human body, but the greatest percentage of its species are inhabitants of the gut. Lactobacilli are well known for their probiotic characteristics, althou...

  • Article
  • Open Access
2 Citations
3,730 Views
20 Pages

Identification of Novel Interspersed DNA Repetitive Elements in the Trypanosoma cruzi Genome Associated with the 3′UTRs of Surface Multigenic Families

  • Simone Guedes Calderano,
  • Milton Yutaka Nishiyama Junior,
  • Marjorie Marini,
  • Nathan de Oliveira Nunes,
  • Marcelo da Silva Reis,
  • José Salvatore Leister Patané,
  • José Franco da Silveira,
  • Julia Pinheiro Chagas da Cunha and
  • Maria Carolina Elias

21 October 2020

Trypanosoma cruzi is the etiological agent of Chagas disease, which affects millions of people in Latin America. No transcriptional control of gene expression has been demonstrated in this organism, and 50% of its genome consists of repetitive elemen...

  • Article
  • Open Access
10 Citations
3,917 Views
17 Pages

bta-miR-23a Regulates the Myogenic Differentiation of Fetal Bovine Skeletal Muscle-Derived Progenitor Cells by Targeting MDFIC Gene

  • Xin Hu,
  • Yishen Xing,
  • Ling Ren,
  • Yahui Wang,
  • Qian Li,
  • Qiyuan Yang,
  • Min Du,
  • Lingyang Xu,
  • Luc Willems and
  • Lupei Zhang
  • + 1 author

20 October 2020

miR-23a, a member of the miR-23a/24-2/27a cluster, has been demonstrated to play pivotal roles in many cellular activities. However, the mechanisms of how bta-miR-23a controls the myogenic differentiation (MD) of PDGFRα bovine progenitor...

  • Article
  • Open Access
1 Citations
6,530 Views
13 Pages

Genome-Wide Co-Expression Distributions as a Metric to Prioritize Genes of Functional Importance

  • Pâmela A. Alexandre,
  • Nicholas J. Hudson,
  • Sigrid A. Lehnert,
  • Marina R. S. Fortes,
  • Marina Naval-Sánchez,
  • Loan T. Nguyen,
  • Laercio R. Porto-Neto and
  • Antonio Reverter

20 October 2020

Genome-wide gene expression analysis are routinely used to gain a systems-level understanding of complex processes, including network connectivity. Network connectivity tends to be built on a small subset of extremely high co-expression signals that...

  • Article
  • Open Access
4 Citations
3,508 Views
17 Pages

20 October 2020

Ceriporiopsis subvermispora is a white-rot fungus with a high specificity towards lignin mineralization when colonizing dead wood or lignocellulosic compounds. Its lignocellulose degrading system is formed by cellulose hydrolytic enzymes, manganese p...

  • Article
  • Open Access
27 Citations
4,224 Views
39 Pages

20 October 2020

In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This st...

  • Article
  • Open Access
11 Citations
4,052 Views
25 Pages

Genome-Wide Transcriptome Profiling Provides Insight on Cholesterol and Lithocholate Degradation Mechanisms in Nocardioides simplex VKM Ac-2033D

  • Victoria Y. Shtratnikova,
  • Mikhail I. Schelkunov,
  • Victoria V. Fokina,
  • Eugeny Y. Bragin,
  • Tatyana G. Lobastova,
  • Andrey A. Shutov,
  • Alexey V. Kazantsev and
  • Marina V. Donova

20 October 2020

Steroid microbial degradation plays a significant ecological role for biomass decomposition and removal/detoxification of steroid pollutants. In this study, the initial steps of cholesterol degradation and lithocholate bioconversion by a strain with...

  • Article
  • Open Access
4 Citations
4,385 Views
19 Pages

19 October 2020

Domestication of a new crop requires identification and improvement of desirable characteristics Field cress (Lepidium campestre) is being domesticated as a new oilseed crop, particularly for northern temperate regions.. In the present study, an F2 m...

  • Review
  • Open Access
34 Citations
5,757 Views
18 Pages

DNA Damage and Repair in Pulmonary Arterial Hypertension

  • Samantha Sharma and
  • Micheala A. Aldred

19 October 2020

Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with both genetic and environmental dynamics contributing to disease progression. Over the last decade, several studies have demonstrated the presence of genomic instability an...

  • Article
  • Open Access
11 Citations
3,678 Views
15 Pages

19 October 2020

Delirium is a complex pathophysiological process, and multiple contributing mechanisms have been identified. However, it is largely unclear how the genes associated with delirium contribute and which of them play key roles. In this study, the genes a...

  • Article
  • Open Access
8 Citations
3,659 Views
11 Pages

Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-β Production and Antiviral Response

  • Hui Huang,
  • Mona Sharma,
  • Yanbing Zhang,
  • Chenxi Li,
  • Ke Liu,
  • Jianchao Wei,
  • Donghua Shao,
  • Beibei Li,
  • Zhiyong Ma and
  • Yafeng Qiu
  • + 1 author

19 October 2020

TRIM26, a member of the tripartite motif (TRIM) family has been shown to be involved in modulation of innate antiviral response. However, the functional characteristics of porcine TRIM26 (porTRIM26) are unclear. In this study, we used a synthesized a...

  • Article
  • Open Access
3 Citations
4,288 Views
18 Pages

Use of Targeted Amplicon Sequencing in Peanut to Generate Allele Information on Allotetraploid Sub-Genomes

  • Roshan Kulkarni,
  • Ratan Chopra,
  • Jennifer Chagoya,
  • Charles E. Simpson,
  • Michael R. Baring,
  • Andrew Hillhouse,
  • Naveen Puppala,
  • Kelly Chamberlin and
  • Mark D. Burow

18 October 2020

The use of molecular markers in plant breeding has become a routine practice, but the cost per accession can be a hindrance to the routine use of Quantitative Trait Loci (QTL) identification in breeding programs. In this study, we demonstrate the use...

  • Article
  • Open Access
23 Citations
5,617 Views
18 Pages

Genetic Architecture Underpinning Yield Components and Seed Mineral–Nutrients in Sesame

  • Naama Teboul,
  • Yaron Gadri,
  • Zipi Berkovich,
  • Ram Reifen and
  • Zvi Peleg

18 October 2020

Genetic dissection of yield components and seed mineral-nutrient is crucial for understanding plant physiological and biochemical processes and alleviate nutrient malnutrition. Sesame (Sesamum indicum L.) is an orphan crop that harbors rich allelic r...

  • Article
  • Open Access
3 Citations
3,758 Views
17 Pages

18 October 2020

One integral step in the transition from a nucleic acid encoded-genome to functional proteins is the aminoacylation of tRNA molecules. To perform this activity, aminoacyl-tRNA synthetases (aaRSs) activate free amino acids in the cell forming an amino...

  • Article
  • Open Access
28 Citations
4,968 Views
18 Pages

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in Aspergillus flavus

  • Jose Lucio,
  • Irene Gonzalez-Jimenez,
  • Olga Rivero-Menendez,
  • Ana Alastruey-Izquierdo,
  • Teresa Pelaez,
  • Laura Alcazar-Fuoli and
  • Emilia Mellado

17 October 2020

Infections caused by Aspergillus species are being increasingly reported. Aspergillus flavus is the second most common species within this genus causing invasive infections in humans, and isolates showing azole resistance have been recently described...

  • Article
  • Open Access
18 Citations
6,104 Views
17 Pages

Genomic Characterization of Methicillin-Resistant Staphylococcus aureus (MRSA) by High-Throughput Sequencing in a Tertiary Care Hospital

  • May Sherif Soliman,
  • Noha Salah Soliman,
  • Arwa Ramadan El-Manakhly,
  • Shahira AbdelSalam ElBanna,
  • Ramy Karam Aziz and
  • Amani Ali El-Kholy

17 October 2020

Methicillin-resistant Staphylococcus aureus (MRSA) strains are associated with serious complications and poor clinical outcome. In Egypt, they contribute to more than 70% of S. aureus healthcare-associated infections. This study combined whole-genome...

  • Article
  • Open Access
6 Citations
8,265 Views
17 Pages

Landscape Genomics of a Widely Distributed Snake, Dolichophis caspius (Gmelin, 1789) across Eastern Europe and Western Asia

  • Sarita Mahtani-Williams,
  • William Fulton,
  • Amelie Desvars-Larrive,
  • Sara Lado,
  • Jean Pierre Elbers,
  • Bálint Halpern,
  • Dávid Herczeg,
  • Gergely Babocsay,
  • Boris Lauš and
  • Pamela Anna Burger
  • + 5 authors

17 October 2020

Across the distribution of the Caspian whipsnake (Dolichophis caspius), populations have become increasingly disconnected due to habitat alteration. To understand population dynamics and this widespread but locally endangered snake’s adaptive p...

  • Article
  • Open Access
9 Citations
6,072 Views
15 Pages

Vertical and Horizontal Transmission of ESBL Plasmid from Escherichia coli O104:H4

  • Sandra Daniel,
  • Kelly Goldlust,
  • Valentin Quebre,
  • Minjia Shen,
  • Christian Lesterlin,
  • Jean-Yves Bouet and
  • Yoshiharu Yamaichi

16 October 2020

Multidrug resistance (MDR) often results from the acquisition of mobile genetic elements (MGEs) that encode MDR gene(s), such as conjugative plasmids. The spread of MDR plasmids is founded on their ability of horizontal transference, as well as their...

  • Article
  • Open Access
29 Citations
9,104 Views
28 Pages

Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion

  • Thomas Sevrin,
  • Clair-Yves Boquien,
  • Alexis Gandon,
  • Isabelle Grit,
  • Pierre de Coppet,
  • Dominique Darmaun and
  • Marie-Cécile Alexandre-Gouabau

16 October 2020

We previously demonstrated galactagogue effect of fenugreek in a rat model of lactation challenge, foreshadowing its use in women’s breastfeeding management. To assess longitudinal molecular mechanisms involved in milk synthesis/secretion in da...

  • Review
  • Open Access
12 Citations
5,962 Views
31 Pages

16 October 2020

The ability of pathogenic bacteria to stably infect the host depends on their capacity to respond and adapt to the host environment and on the efficiency of their defensive mechanisms. Bacterial envelope provides a physical barrier protecting against...

  • Review
  • Open Access
58 Citations
9,360 Views
20 Pages

16 October 2020

Hypericum perforatum L. commonly known as Saint John’s Wort (SJW), is an important medicinal plant that has been used for more than 2000 years. Although H. perforatum produces several bioactive compounds, its importance is mainly linked to two...

  • Case Report
  • Open Access
1 Citations
3,063 Views
7 Pages

A Case Report of Left Atrial Isomerism in a Syndromic Context

  • Aurora Ilian,
  • Andrei Motoc,
  • Ligia Balulescu,
  • Cristina Secosan,
  • Dorin Grigoras and
  • Laurentiu Pirtea

16 October 2020

The objective of our paper is to underline the importance of assessing microarray genetic analysis for the detection of chromosomal abnormalities in rare cases such as left atrial isomerism, mostly in the context of antenatally detected syndromes. We...

  • Review
  • Open Access
22 Citations
7,699 Views
14 Pages

16 October 2020

Chronic inflammatory bowel disease (IBD) includes Crohn’s disease and ulcerative colitis. Both are characterized by inflammation of part of the digestive tract lining. Azathioprine (AZA) is a well-known immunosuppressant that has been known for...

  • Review
  • Open Access
33 Citations
6,232 Views
16 Pages

16 October 2020

Pulmonary arterial hypertension (PAH) is a rare disease with high mortality despite recent therapeutic advances. The disease is caused by both genetic and environmental factors and likely gene–environment interactions. While PAH can manifest ac...

  • Case Report
  • Open Access
6 Citations
3,781 Views
8 Pages

SLC19A3 Loss-of-Function Variant in Yorkshire Terriers with Leigh-Like Subacute Necrotizing Encephalopathy

  • Michaela Drögemüller,
  • Anna Letko,
  • Kaspar Matiasek,
  • Vidhya Jagannathan,
  • Daniele Corlazzoli,
  • Marco Rosati,
  • Konrad Jurina,
  • Susanne Medl,
  • Thomas Gödde and
  • Cord Drögemüller
  • + 3 authors

16 October 2020

Sporadic occurrence of juvenile-onset necrotizing encephalopathy (SNE) has been previously reported in Yorkshire terriers. However, so far, no causative genetic variant has been found for this breed-specific form of suspected mitochondrial encephalom...

  • Article
  • Open Access
13 Citations
5,581 Views
21 Pages

16 October 2020

Single-cell RNA sequencing has become a standard technique to characterize tissue development. Hereby, cross-sectional snapshots of the diversity of cell transcriptomes were transformed into (pseudo-) longitudinal trajectories of cell differentiation...

  • Article
  • Open Access
13 Citations
6,135 Views
28 Pages

Comparative Study of Pine Reference Genomes Reveals Transposable Element Interconnected Gene Networks

  • Angelika Voronova,
  • Martha Rendón-Anaya,
  • Pär Ingvarsson,
  • Ruslan Kalendar and
  • Dainis Ruņģis

16 October 2020

Sequencing the giga-genomes of several pine species has enabled comparative genomic analyses of these outcrossing tree species. Previous studies have revealed the wide distribution and extraordinary diversity of transposable elements (TEs) that occup...

  • Article
  • Open Access
9 Citations
2,707 Views
13 Pages

Characterization of Quantitative Trait Loci for Germination and Coleoptile Length under Low-Temperature Condition Using Introgression Lines Derived from an Interspecific Cross in Rice

  • Mirjalol Akhtamov,
  • Cheryl Adeva,
  • Kyu-Chan Shim,
  • Hyun-Sook Lee,
  • Sun Ha Kim,
  • Yun-A Jeon,
  • Ngoc Ha Luong,
  • Ju-Won Kang,
  • Ji-Yoon Lee and
  • Sang-Nag Ahn

15 October 2020

Previously, five putative quantitative trait loci (QTLs) for low-temperature germination (LTG) have been detected using 96 BC3F8 lines derived from an interspecific cross between the Korean japonica cultivar “Hwaseong” and Oryza rufipogon...

  • Article
  • Open Access
24 Citations
4,094 Views
9 Pages

Two New Cases of Hypertrophic Cardiomyopathy and Skeletal Muscle Features Associated with ALPK3 Homozygous and Compound Heterozygous Variants

  • John Jorholt,
  • Yulia Formicheva,
  • Tatyana Vershinina,
  • Artem Kiselev,
  • Alexey Muravyev,
  • Elena Demchenko,
  • Petr Fedotov,
  • Anna Zlotina,
  • Anton Rygkov and
  • Anna Kostareva
  • + 2 authors

15 October 2020

Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy c...

  • Article
  • Open Access
1 Citations
3,732 Views
27 Pages

R2 and Non-Site-Specific R2-Like Retrotransposons of the German Cockroach, Blattella germanica

  • Arina Zagoskina,
  • Sergei Firsov,
  • Irina Lazebnaya,
  • Oleg Lazebny and
  • Dmitry V. Mukha

15 October 2020

The structural and functional organization of the ribosomal RNA gene cluster and the full-length R2 non-LTR retrotransposon (integrated into a specific site of 28S ribosomal RNA genes) of the German cockroach, Blattella germanica, is described. A par...

  • Article
  • Open Access
7 Citations
3,479 Views
19 Pages

15 October 2020

Ascorbate peroxidase (APX) is an important antioxidant enzyme. APXs in maize are encoded by multiple genes and exist as isoenzymes. The evolutionary history and functional divergence of the maize APX gene family were analyzed through comparative geno...

  • Review
  • Open Access
9 Citations
3,729 Views
8 Pages

15 October 2020

Tacrolimus-modified release formulations allow for once-daily dosing, and adherence is better compared to the twice-daily immediate release formulation. When patients are switched from one formulation to another, variable changes in drug concentratio...

  • Review
  • Open Access
124 Citations
12,433 Views
13 Pages

15 October 2020

This review describes the cytokinesis-block micronucleus (CBMN) cytome assay and its evolution into a molecular cytogenetic method of chromosomal instability (CIN). Micronuclei (MNi) originate from whole chromosomes or chromosome fragments that fail...

  • Article
  • Open Access
23 Citations
6,996 Views
18 Pages

Genetic Risk of Autism Spectrum Disorder in a Pakistani Population

  • Madiha Khalid,
  • Hashim Raza,
  • Terri M. Driessen,
  • Paul J. Lee,
  • Leon Tejwani,
  • Abdul Sami,
  • Muhammad Nawaz,
  • Shahid Mehmood Baig,
  • Janghoo Lim and
  • Ghazala Kaukab Raja

15 October 2020

Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental and neuropsychiatric disorders in children characterized by impairment of communication and social interaction. Several genes with associated single nucleotide pol...

  • Article
  • Open Access
6 Citations
3,003 Views
17 Pages

The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population

  • Guadalupe León-Reyes,
  • Berenice Rivera-Paredez,
  • Juan Carlos Fernandez López,
  • Eric G. Ramírez-Salazar,
  • Arnoldo Aquino-Gálvez,
  • Katia Gallegos-Carrillo,
  • Edgar Denova-Gutiérrez,
  • Jorge Salmerón and
  • Rafael Velázquez-Cruz

14 October 2020

The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a p...

  • Article
  • Open Access
10 Citations
3,880 Views
9 Pages

Population Genetic Structure of the Wild Boar (Sus scrofa) in the Carpathian Basin

  • Bendegúz Mihalik,
  • Krisztián Frank,
  • Putri Kusuma Astuti,
  • Dániel Szemethy,
  • László Szendrei,
  • László Szemethy,
  • Szilvia Kusza and
  • Viktor Stéger

14 October 2020

In the Carpathian Basin the wild boar (Sus scrofa) belongs among the most important game species both ecologically and economically, therefore knowing more about the basics of the genetics of the species is a key factor for accurate and sustainable m...

  • Feature Paper
  • Article
  • Open Access
15 Citations
6,821 Views
15 Pages

Campylobacter jejuni Cas9 Modulates the Transcriptome in Caco-2 Intestinal Epithelial Cells

  • Chinmoy Saha,
  • Deborah Horst-Kreft,
  • Inez Kross,
  • Peter J. van der Spek,
  • Rogier Louwen and
  • Peter van Baarlen

14 October 2020

The zoonotic human pathogen Campylobacter jejuni is known for its ability to induce DNA-damage and cell death pathology in humans. The molecular mechanism behind this phenomenon involves nuclear translocation by Cas9, a nuclease in C. jejuni (CjeCas9...

  • Article
  • Open Access
14 Citations
3,336 Views
14 Pages

Induction of Chicken Host Defense Peptides within Disease-Resistant and -Susceptible Lines

  • Hyun-Jun Jang,
  • Melissa Monson,
  • Michael Kaiser and
  • Susan J Lamont

14 October 2020

Host defense peptides (HDPs) are multifunctional immune molecules that respond to bacterial and viral pathogens. In the present study, bone marrow-derived cells (BMCs) and chicken embryonic fibroblasts (CEFs) were cultured from a Leghorn line (Ghs6)...

  • Review
  • Open Access
51 Citations
8,587 Views
26 Pages

Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

  • Alfonso Herreros-Cabello,
  • Francisco Callejas-Hernández,
  • Núria Gironès and
  • Manuel Fresno

14 October 2020

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people. Although its first genome dates from 2005, its complexity hindered a complete assembly and annotation. However, the new sequencing methods have improved genome annota...

  • Article
  • Open Access
12 Citations
4,336 Views
17 Pages

Drought-Tolerance Gene Identification Using Genome Comparison and Co-Expression Network Analysis of Chromosome Substitution Lines in Rice

  • Chutarat Punchkhon,
  • Kitiporn Plaimas,
  • Teerapong Buaboocha,
  • Jonaliza L. Siangliw,
  • Theerayut Toojinda,
  • Luca Comai,
  • Nuria De Diego,
  • Lukáš Spíchal and
  • Supachitra Chadchawan

14 October 2020

Drought stress limits plant growth and productivity. It triggers many responses by inducing changes in plant morphology and physiology. KDML105 rice is a key rice variety in Thailand and is normally grown in the northeastern part of the country. The...

  • Article
  • Open Access
5 Citations
3,106 Views
16 Pages

The Leishmania donovani SENP Protease Is Required for SUMO Processing but Not for Viability

  • Annika Bea,
  • Constanze Kröber-Boncardo,
  • Manpreet Sandhu,
  • Christine Brinker and
  • Joachim Clos

14 October 2020

The protozoan parasite Leishmania donovani is part of an early eukaryotic branch and depends on post-transcriptional mechanisms for gene expression regulation. This includes post-transcriptional protein modifications, such as protein phosphorylation....

  • Article
  • Open Access
3 Citations
3,027 Views
17 Pages

13 October 2020

Epigenetic alterations, such as histone methylations, affect the pathogenesis of tumors including prostate cancer (PCa). Previously, we reported that metformin reduced SUV39H1, a histone methyltransferase of H3 Lys9, to inhibit the migration of PCa c...

  • Article
  • Open Access
33 Citations
4,292 Views
13 Pages

Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic Tissues

  • Zeyi Zhou,
  • Yan Liu,
  • Xiyu Zhu,
  • Xinlong Tang,
  • Yali Wang,
  • Junxia Wang,
  • Can Xu,
  • Dongjin Wang,
  • Jie Du and
  • Qing Zhou

13 October 2020

Stanford type A aortic dissection (TAAD) is one of the most dangerous diseases of acute aortic syndrome. Molecular pathological studies on TAAD can aid in understanding the disease comprehensively and can provide insights into new diagnostic markers...

  • Article
  • Open Access
13 Citations
3,817 Views
9 Pages

13 October 2020

Klebsiella pneumoniae (Kp) is one of the most important etiological factors of urinary tract infections in renal transplant (RTx) recipients. We described the antimicrobial susceptibility phenotypes and genomic features of two hypermucoviscous (HM) K...

  • Technical Note
  • Open Access
30 Citations
7,935 Views
15 Pages

13 October 2020

Seed aging is a complex biological process and its fundamentals and mechanisms have not yet been fully recognized. This is a key issue faced by research teams involved in the collection and storage of plant genetic resources in gene banks every day....

  • Article
  • Open Access
19 Citations
3,776 Views
12 Pages

Genetic Evaluation in a Cohort of 126 Dutch Pulmonary Arterial Hypertension Patients

  • Lieke M. van den Heuvel,
  • Samara M. A. Jansen,
  • Suzanne I. M. Alsters,
  • Marco C. Post,
  • Jasper J. van der Smagt,
  • Frances S. Handoko-De Man,
  • J. Peter van Tintelen,
  • Hans Gille,
  • Imke Christiaans and
  • Arjan C. Houweling
  • + 2 authors

13 October 2020

Pulmonary arterial hypertension (PAH) is a severe, life-threatening disease, and in some cases is caused by genetic defects. This study sought to assess the diagnostic yield of genetic testing in a Dutch cohort of 126 PAH patients. Historically, gene...

  • Feature Paper
  • Review
  • Open Access
31 Citations
7,569 Views
14 Pages

12 October 2020

Poultry such as chickens are valuable model animals not only in the food industry, but also in developmental biology and biomedicine. Recently, precise genome-editing technologies mediated by the CRISPR/Cas9 system have developed rapidly, enabling th...

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Genes - ISSN 2073-4425