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Genes, Volume 11, Issue 11

2020 November - 154 articles

Cover Story: To date, there is little evidence supporting a role of Y chromosome genetic variation in relation to human complex traits. This review summarises inherent complexities specific to the Y chromosome related to its structure, function and population history that make the human Y chromosome a complex locus, different from all other human chromosomes. We propose that this complexity needs to be taken into account in the design and interpretation of genetic epidemiological studies involving chromosome Y. In particular, we discuss evidence and propose novel ideas about the consideration of haplogroups in genetic association studies of the human Y chromosome and complex traits. View this paper
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Articles (154)

  • Article
  • Open Access
13 Citations
4,879 Views
15 Pages

23 November 2020

Recent studies supported a clinical association between Parkinson’s disease (PD) and periodontitis. Hence, investigating possible interactions between proteins associated to these two conditions is of interest. In this study, we conducted a pro...

  • Article
  • Open Access
20 Citations
3,820 Views
15 Pages

23 November 2020

Pinus massoniana Lamb, an economically important conifer tree, is widely distributed in China. WRKY transcription factors (TFs) play important roles in plant growth and development, biological and abiotic stress. Nevertheless, there is little informa...

  • Article
  • Open Access
25 Citations
7,980 Views
25 Pages

GWAS Based on RNA-Seq SNPs and High-Throughput Phenotyping Combined with Climatic Data Highlights the Reservoir of Valuable Genetic Diversity in Regional Tomato Landraces

  • Monica Rodriguez,
  • Alessandro Scintu,
  • Chiara M. Posadinu,
  • Yimin Xu,
  • Cuong V. Nguyen,
  • Honghe Sun,
  • Elena Bitocchi,
  • Elisa Bellucci,
  • Roberto Papa and
  • Giovanna Attene
  • + 3 authors

23 November 2020

Tomato (Solanum lycopersicum L.) is a widely used model plant species for dissecting out the genomic bases of complex traits to thus provide an optimal platform for modern “-omics” studies and genome-guided breeding. Genome-wide associati...

  • Article
  • Open Access
39 Citations
6,812 Views
18 Pages

Genomic Identification, Evolution and Sequence Analysis of the Heat-Shock Protein Gene Family in Buffalo

  • Saif ur Rehman,
  • Asif Nadeem,
  • Maryam Javed,
  • Faiz-ul Hassan,
  • Xier Luo,
  • Ruqayya Bint Khalid and
  • Qingyou Liu

23 November 2020

Heat-shock proteins (HSP) are conserved chaperones crucial for protein degradation, maturation, and refolding. These adenosine triphosphate dependent chaperones were classified based on their molecular mass that ranges between 10–100 kDA, inclu...

  • Article
  • Open Access
18 Citations
4,037 Views
18 Pages

23 November 2020

The trihelix transcription factor (GT) family is widely involved in regulating plant growth and development, and most importantly, responding to various abiotic stresses. Our study first reported the genome-wide identification and analysis of GT fami...

  • Review
  • Open Access
38 Citations
6,765 Views
23 Pages

22 November 2020

Fucosidosis is a neurodegenerative disorder which progresses inexorably. Clinical features include coarse facial features, growth retardation, recurrent upper respiratory infections, dysostosis multiplex, and angiokeratoma corporis diffusum. Fucosido...

  • Article
  • Open Access
26 Citations
5,669 Views
22 Pages

Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer

  • Justin Wang,
  • Ingrid Vallee,
  • Aditi Dutta,
  • Yu Wang,
  • Zhongying Mo,
  • Ze Liu,
  • Haissi Cui,
  • Andrew I. Su and
  • Xiang-Lei Yang

22 November 2020

Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIM...

  • Case Report
  • Open Access
2,649 Views
8 Pages

A Novel Germline c.1267T>A MEN1 Mutation in MEN1 Family—from Phenotype to Gene and Back

  • Wojciech Gierlikowski,
  • Agata Skwarek-Szewczyk and
  • Michał Popow

21 November 2020

Primary hyperparathyroidism is a relatively common endocrine disorder, which may be hereditary. This report describes clinical, biochemical, radiographic, and genetic findings, the latter obtained using next generation sequencing (NGS), in three cons...

  • Article
  • Open Access
16 Citations
6,810 Views
17 Pages

Metagenomic Information Recovery from Human Stool Samples Is Influenced by Sequencing Depth and Profiling Method

  • Tasha M. Santiago-Rodriguez,
  • Aaron Garoutte,
  • Emmase Adams,
  • Waleed Nasser,
  • Matthew C. Ross,
  • Alex La Reau,
  • Zachariah Henseler,
  • Tonya Ward,
  • Dan Knights and
  • Emily B. Hollister
  • + 1 author

21 November 2020

Sequencing of the 16S rRNA gene (16S) has long been a go-to method for microbiome characterization due to its accessibility and lower cost compared to shotgun metagenomic sequencing (SMS). However, 16S sequencing rarely provides species-level resolut...

  • Article
  • Open Access
16 Citations
3,808 Views
17 Pages

Differential Gene Expression in Longissimus Dorsi Muscle of Hanwoo Steers—New Insight in Genes Involved in Marbling Development at Younger Ages

  • Sara de las Heras-Saldana,
  • Ki Yong Chung,
  • Hyounju Kim,
  • Dajeong Lim,
  • Cedric Gondro and
  • Julius H. J. van der Werf

21 November 2020

The Korean Hanwoo breed possesses a high capacity to accumulate intramuscular fat, which is measured as a marbling score in the beef industry. Unfortunately, the development of marbling is not completely understood and the identification of different...

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Genes - ISSN 2073-4425