Special Issue "Kinetoplastid Genomics and Beyond"
Deadline for manuscript submissions: closed (10 September 2020).
Interests: Leishmania; Trypanosoma; heat shock proteins; RNA binding proteins; regulation of gene expression; genomics; transcriptomics
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For a long time, kinetoplastid protists (class Kinetoplastea) have attracted a great deal of scientific attention because this group includes several organisms of tremendous medical and economic importance (e.g., Trypanosoma ssp., causing Chagas disease and sleeping sickness in humans; and Leishmania spp., causing kala-azar and other leishmaniases). Moreover, many parasites for plants (Phytomonas spp.) and insects (Leptomonas, Crithidia, and other genera) also belong to this class. In addition, free-living kinetoplastids are abundant and active microbial predators in terrestrial and aquatic ecosystems.
On the other hand, these organisms are also the objects of considerable basic scientific interest due to their bizarre cytology, genome organization, and mechanisms of gene regulation. In recent years, the incorporation of “omics” methodologies to the study of these organisms has allowed assembly of the genomes for a growing number of both parasitic and free-living kinetoplastids to analyze changes in gene expression, determine the proteome compendium, establish metabolic pathways, and so on.
The aim of this Special Issue is to bring together a set of reviews and research articles addressing aspects like genome organization, mechanisms of gene expression, specific metabolic pathways, evolutionary relationships and databases, among others, focused on any species belonging to this group of protists.
Dr. Jose M. Requena
Manuscript Submission Information
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- genome assembly and annotation
- regulation and gene expression