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Cells, Volume 11, Issue 24

2022 December-2 - 193 articles

Cover Story: Laminins (LNs) play a central role in the self-assembly and maintenance of basement membranes and are involved in critical interactions between cells and other extracellular matrix proteins. Polylaminin (polyLN) is an acidification-induced LN mimic that recapitulates the native-like polymeric array in cell-free systems. Here, we characterize the native-like hexagonal structure of polyLN-521 and demonstrate that polyLN521 improves the adhesion and proliferation of human induced pluripotent stem cells (hiPSCs) compared with LN521 or Matrigel. Furthermore, hiPSCs cultivated on a low concentration of polyLN521 maintain the pluripotent state. Thus, polyLN521 is a feasible and cost-effective candidate for a chemically defined, xeno-free coating in the large-scale expansion of hiPSCs. These findings further illustrate that the biological activity of LNs is enhanced when assembled in acidic pH. View this paper
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Articles (193)

  • Article
  • Open Access
12 Citations
3,010 Views
11 Pages

Sensing Cells-Peptide Hydrogel Interaction In Situ via Scanning Ion Conductance Microscopy

  • Tatiana N. Tikhonova,
  • Vasilii S. Kolmogorov,
  • Roman V. Timoshenko,
  • Alexander N. Vaneev,
  • Dana Cohen-Gerassi,
  • Liubov A. Osminkina,
  • Petr V. Gorelkin,
  • Alexander S. Erofeev,
  • Nikolay N. Sysoev and
  • Evgeny A. Shirshin
  • + 1 author

19 December 2022

Peptide-based hydrogels were shown to serve as good matrices for 3D cell culture and to be applied in the field of regenerative medicine. The study of the cell-matrix interaction is important for the understanding of cell attachment, proliferation, a...

  • Article
  • Open Access
4 Citations
2,843 Views
14 Pages

Single-Cell RNAseq Resolve the Potential Effects of LanCL1 Gene in the Mouse Testis

  • Jiangting Lu,
  • Jinling Liao,
  • Min Qin,
  • Hui Li,
  • Qingyuan Zhang,
  • Yang Chen and
  • Jiwen Cheng

19 December 2022

Infertility affects lots of couples, half of which are caused by male factors. The LanCL1 gene is highly expressed in testis specifically, which might affect the development of sperms. In order to understand the potential functions of the LanCL1 gene...

  • Review
  • Open Access
17 Citations
5,946 Views
13 Pages

19 December 2022

Coronary heart disease (CHD) is the leading cause of death around the world. Based on the roles of vascular endothelial growth factor (VEGF) family members to regulate blood and lymphatic vessels and metabolic functions, several therapeutic approache...

  • Article
  • Open Access
22 Citations
3,854 Views
15 Pages

Lactobacillus salivarius SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens

  • Lihui Zhu,
  • Rongrong Liao,
  • Jiwen Huang,
  • Changfeng Xiao,
  • Yunzhou Yang,
  • Huiying Wang,
  • Daqian He,
  • Huaxiang Yan and
  • Changsuo Yang

19 December 2022

Lactobacillus spp., as probiotics, have shown efficacy in alleviating nonalcoholic fatty liver disease (NAFLD). Here, we screened a new probiotic strain, Lactobacillus salivarius SNK-6 (L. salivarius SNK-6), which was isolated from the ileum of healt...

  • Review
  • Open Access
11 Citations
6,957 Views
28 Pages

19 December 2022

Metabolic rewiring and defective immune responses are considered to be the main driving forces sustaining cell growth and oncogenesis in many cancers. The atypical enzyme, proprotein convertase subtilisin/kexin type 9 (PCSK9), is produced by the live...

  • Article
  • Open Access
2 Citations
2,042 Views
11 Pages

Redox Genetic Risk Score and the Incidence of End-Stage Kidney Disease in People with Type 1 Diabetes

  • Kamel Mohammedi,
  • Michel Marre,
  • Samy Hadjadj,
  • Louis Potier and
  • Gilberto Velho

19 December 2022

End-stage kidney disease (ESKD) is a multifactorial condition influenced by genetic background, but the extent to which a genetic risk score (GRS) improves ESKD prediction is unknown. We built a redox GRS on the base of previous association studies (...

  • Article
  • Open Access
3 Citations
2,711 Views
11 Pages

Expression and Kinetics of Endogenous Cannabinoids in the Brain and Spinal Cord of a Spare Nerve Injury (SNI) Model of Neuropathic Pain

  • Kenta Kurosu,
  • Ariful Islam,
  • Tomohito Sato,
  • Tomoaki Kahyo,
  • Tomohiro Banno,
  • Noriko Sato,
  • Yukihiro Matsuyama and
  • Mitsutoshi Setou

19 December 2022

The role of endogenous cannabinoids in neuropathic pain has been actively studied, among which 2-arachidonoyl glycerol (2-AG) has received the most attention. However, owing to its chemical properties, direct detection of 2-AG distribution in tissues...

  • Review
  • Open Access
13 Citations
4,811 Views
29 Pages

Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications

  • Maryam Rahimi Tesiye,
  • Mohammad Gol,
  • Mohammad Rajabi Fadardi,
  • Seyede Nasim Mousavi Kani,
  • Anna-Maria Costa,
  • Maryam Ghasemi-Kasman and
  • Giuseppe Biagini

19 December 2022

Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternativ...

  • Article
  • Open Access
29 Citations
3,928 Views
10 Pages

UC-BSCs Exosomes Regulate Th17/Treg Balance in Patients with Systemic Lupus Erythematosus via miR-19b/KLF13

  • Jianxin Tu,
  • Nan Zheng,
  • Chentong Mao,
  • Shan Liu,
  • Hongxing Zhang and
  • Li Sun

19 December 2022

Umbilical cord blood mesenchymal stem cells (UC-BSCs) are cells with low immunogenicity and differentiation potential, and the transfer of exosomes carried by UC-BSCs can regulate innate and adaptive immunity and affect immune homeostasis. This is an...

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Cells - ISSN 2073-4409