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Review

From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, 69120 Heidelberg, Germany
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Academic Editors: Chun Zhang Yang and Prashant Chittiboina
Cells 2021, 10(5), 1225; https://doi.org/10.3390/cells10051225
Received: 9 April 2021 / Revised: 7 May 2021 / Accepted: 7 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Molecular Basis of Brain Tumors)
In this review, we discuss the use of the alkylating agent temozolomide (TMZ) in the treatment of IDH-mutant gliomas. We describe the challenges associated with TMZ in clinical (drug resistance and tumor recurrence) and preclinical settings (variabilities associated with in vitro models) in treating IDH-mutant glioma. Lastly, we summarize the emerging therapeutic targets that can potentially be used in combination with TMZ. View Full-Text
Keywords: IDH-mutant glioma; TMZ; combination therapy IDH-mutant glioma; TMZ; combination therapy
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MDPI and ACS Style

Sun, X.; Turcan, S. From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas. Cells 2021, 10, 1225. https://doi.org/10.3390/cells10051225

AMA Style

Sun X, Turcan S. From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas. Cells. 2021; 10(5):1225. https://doi.org/10.3390/cells10051225

Chicago/Turabian Style

Sun, Xueyuan, and Sevin Turcan. 2021. "From Laboratory Studies to Clinical Trials: Temozolomide Use in IDH-Mutant Gliomas" Cells 10, no. 5: 1225. https://doi.org/10.3390/cells10051225

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