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Crystals, Volume 15, Issue 9

September 2025 - 84 articles

Cover Story: The SARS-CoV-2 main protease (Mpro) is a well-established target for antiviral drug development. However, being an RNA virus, SARS-CoV-2 is prone to the emergence of resistance mutations. A number of these mutations have been characterized, although they have not yet been shown to play a significant role in clinical settings; these include S144A, E166V, H172Y, and Q189K. We recombinantly produced these mutants and studied the corresponding proteins using X-ray crystallography, enzymology, and biophysical approaches. We discuss the potential of each mutant to lead to a widespread nirmatrelvir resistance scenario. We also demonstrate that one of our own inhibitors (13b-K), while showing some degree of cross-resistance with nirmatrelvir, exhibits much higher inhibitory activity against the Mpro carrying the E166V mutation. View this paper
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Articles (84)

  • Review
  • Open Access
2,147 Views
30 Pages

Recent Advancements in N-polar GaN HEMT Technology

  • Emre Akso,
  • Kamruzzaman Khan,
  • Henry Collins,
  • Boyu Wang,
  • Robert Hamwey,
  • Tanmay Chavan,
  • Christopher Clymore,
  • Weiyi Li,
  • Oguz Odabasi and
  • Matthew Guidry
  • + 4 authors

22 September 2025

N-polar GaN HEMT technology has emerged as a disruptive technology that outperforms Ga-polar GaN HEMTs in terms of high-frequency power amplification capability. In this paper, the authors present a comprehensive review of the evolution of N-polar Ga...

  • Article
  • Open Access
655 Views
13 Pages

The Influence of Pressure on Magnetite–Zinc Oxide Synthesis in Hydrothermal Conditions

  • Miruna-Adriana Ioța,
  • Laura-Mădălina Cursaru,
  • Ioan Albert Tudor,
  • Marian-Nicolae Costea,
  • Alexandru Cristian Matei,
  • Dumitru Valentin Dragut,
  • Roxana Mioara Piticescu and
  • Adriana-Gabriela Șchiopu

22 September 2025

The combination of ZnO and Fe3O4 nanoparticles represents a synergistic strategy for the treatment of skin cancer, exploiting both oxidative stress-induced cytotoxicity and hyperthermic effects for improved anticancer activity. These nanoparticles al...

  • Article
  • Open Access
668 Views
18 Pages

Study of Neutron Absorption of Reactor Spectrum by Composites Based on UHMWPE

  • Yernat A. Kozhakhmetov,
  • Mazhyn K. Skakov,
  • Bauyrzhan T. Tuyakbayev,
  • Yerzhan Ye. Sapatayev and
  • Alexandr V. Gradoboev

20 September 2025

The development of radiation-protective materials with high resistance under reactor irradiation conditions is one of the urgent tasks in modern nuclear technologies. Ultra-high molecular weight polyethylene (UHMWPE) is considered a promising matrix...

  • Article
  • Open Access
1 Citations
527 Views
32 Pages

20 September 2025

This study introduces a novel numerical approach to analyze the axisymmetric bending behavior of functionally graded (FG) graphene platelet (GPL)-reinforced annular sandwich nanoplates featuring a porous core. The nanostructures are exposed to couple...

  • Article
  • Open Access
725 Views
15 Pages

Growth and Atomic-Scale Characterization of 2D Gallium Selenide Crystals via STEM and EELS

  • Antonio Serra,
  • Letizia Meleleo,
  • Alessandro Buccolieri,
  • Lucio Calcagnile and
  • Daniela Manno

20 September 2025

The advent of graphene has catalyzed extensive exploration into two-dimensional (2D) materials, among which gallium selenide (GaSe)—a layered semiconductor—stands out for its promise in optoelectronic and nanoscale device applications. To...

  • Article
  • Open Access
817 Views
16 Pages

Microgravity-Grown Crystals as Seeds for Pharmaceutical Compounds

  • Jessica Paulson,
  • Lillian Miller,
  • Stephen Tuma,
  • Molly K. Mulligan,
  • Kenneth A. Savin and
  • Anne M. Wilson

20 September 2025

Polymorph formation of pharmaceutical agents continues to be a challenge for the industry. Using seeds to provide the desired polymorphic form is a practice that circumvents this obstacle. Crystals grown in a microgravity environment provide an optim...

  • Article
  • Open Access
645 Views
16 Pages

20 September 2025

Freshwater bead-cultured pearls (FWBCPs) from Zhuji, China, have gained significant market prominence due to their large size, unique pearl luster, and diverse color. This study systematically investigated the mineral compositions and organic color-r...

  • Article
  • Open Access
556 Views
19 Pages

19 September 2025

The reaction system of nanocrystalline iron carburization and carbon deposit formation as an example of a parallel chemical reaction was studied. The main measurement procedure was the Chemical Potential Programmed Reaction method, according to which...

  • Article
  • Open Access
491 Views
14 Pages

Light-Induced Heating of Microsized Nematic Volumes

  • Dmitrii Shcherbinin,
  • Denis A. Glukharev,
  • Semyon Rudyi,
  • Anastasiia Piven,
  • Tetiana Orlova,
  • Izabela Śliwa and
  • Alex Zakharov

19 September 2025

The experimental study has been carried out using advanced computer vision methods in order to visualize the moment of excitation and further propagation of a non stationary isotropic domain in a hybrid aligned nematic (HAN) microsized volume under t...

  • Article
  • Open Access
526 Views
13 Pages

19 September 2025

First examples of mononuclear homoleptic zinc aminopyridinates have been isolated by reacting the sterically bulky deprotonated 2-aminopyridine ligands, N-(2,6-diisopropylphenyl)-[6-(2,6-dimethylphenyl)-pyridine-2-yl]-amine (1) and N-(2,6-diisopropyl...

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Crystals - ISSN 2073-4352