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Cancers, Volume 9, Issue 3

2017 March - 6 articles

Cover Story: The progression of prostate cancer (PC) is influenced by androgens and the androgen receptor (AR). PC develops resistance to low testosterone levels called castration-resistant PC (CRPC). Surprisingly, the AR signaling pathway are still activated by some of the AR collaborative transcription factors (TFs) in most CRPC cases. Therefore, elucidating the crosstalk between the AR and collaborative TFs on the AR pathway is critical for developing new strategies for the treatment of CRPC. We summarize the AR signaling pathways in terms of collaborative TFs and focus on pyrrole-imidazole polyamides as candidate compounds for the treatment of PC. View the paper
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Articles (6)

  • Article
  • Open Access
48 Citations
8,559 Views
11 Pages

Predictors of Posttraumatic Stress and Posttraumatic Growth in Childhood Cancer Survivors

  • Veronika Koutná,
  • Martin Jelínek,
  • Marek Blatný and
  • Tomáš Kepák

16 March 2017

This longitudinal study aims to analyze predictors of posttraumatic stress symptoms (PTSS) and posttraumatic growth (PTG) among gender, age, objective factors of the disease and its treatment, family environment factors and negative emotionality. The...

  • Review
  • Open Access
64 Citations
13,240 Views
17 Pages

11 March 2017

Dissecting the cellular signaling that governs the motility of eukaryotic cells is one of the fundamental tasks of modern cell biology, not only because of the large number of physiological processes in which cell migration is crucial, but even more...

  • Review
  • Open Access
35 Citations
8,940 Views
10 Pages

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment

  • David Gyori,
  • Tamara Chessa,
  • Phillip T. Hawkins and
  • Len R. Stephens

4 March 2017

Phosphoinositide 3-kinases (PI3Ks) are a diverse family of enzymes which regulate various critical biological processes, such as cell proliferation and survival. Class (I) PI3Ks (PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ) mediate the phosphorylation of the inosi...

  • Review
  • Open Access
14 Citations
8,010 Views
13 Pages

Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)

  • Yutaka Yonemura,
  • Yoshio Endo,
  • Emel Canbay,
  • Yang Liu,
  • Haruaki Ishibashi,
  • Akiyoshi Mizumoto,
  • Masamitu Hirano,
  • Yuuki Imazato,
  • Nobuyuki Takao and
  • Shun-ichiro Ogura
  • + 8 authors

1 March 2017

In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long...

  • Review
  • Open Access
37 Citations
9,912 Views
19 Pages

28 February 2017

Prostate cancer is the second leading cause of death from cancer among males in Western countries. It is also the most commonly diagnosed male cancer in Japan. The progression of prostate cancer is mainly influenced by androgens and the androgen rece...

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Cancers - ISSN 2072-6694