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Cancers, Volume 17, Issue 3

February-1 2025 - 226 articles

Cover Story: The human papillomavirus (HPV) is a prevalent sexually transmitted infection known to cause numerous morbidities, which have increased significantly over two decades. This study investigated awareness and knowledge of HPV, oropharyngeal cancer (OPC), and the HPV vaccine. University students (n = 1005) answered questions related to their awareness and knowledge of HPV. The results indicate relatively high levels of awareness but significant gaps in their knowledge of HPV, OPC, and the HPV vaccine. These data suggest that such limitations may place younger adults at greater risk for HPV-related infections. The present data may guide future efforts directed toward better education on HPV. View this paper
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Articles (226)

  • Article
  • Open Access
3 Citations
2,020 Views
22 Pages

GATA3-Driven ceRNA Network in Lung Adenocarcinoma Bone Metastasis Progression and Therapeutic Implications

  • Yun Liu,
  • Shihui Shen,
  • Xudong Wang,
  • Hansen Chen,
  • Wenjie Ren,
  • Haifeng Wei,
  • Kun Li and
  • Lei Li

6 February 2025

Background/Objectives: Bone metastasis is a common and severe complication of lung adenocarcinoma (LUAD), impacting prognosis and treatment outcomes. Understanding the molecular mechanisms behind LUAD bone metastasis (LUADBM) is essential for develop...

  • Systematic Review
  • Open Access
1 Citations
2,590 Views
23 Pages

Applications of Artificial Intelligence for Metastatic Gastrointestinal Cancer: A Systematic Literature Review

  • Amin Naemi,
  • Ashkan Tashk,
  • Amir Sorayaie Azar,
  • Tahereh Samimi,
  • Ghanbar Tavassoli,
  • Anita Bagherzadeh Mohasefi,
  • Elaheh Nasiri Khanshan,
  • Mehrdad Heshmat Najafabad,
  • Vafa Tarighi and
  • Uffe Kock Wiil
  • + 3 authors

6 February 2025

Background/Objectives: This systematic literature review examines the application of Artificial Intelligence (AI) in the diagnosis, treatment, and follow-up of metastatic gastrointestinal cancers. Methods: The databases PubMed, Scopus, Embase (Ovid),...

  • Review
  • Open Access
11 Citations
6,394 Views
16 Pages

6 February 2025

Effective available treatment options for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who relapse after becoming refractory to both a covalent Bruton Tyrosine Kinase inhibitor (cBTKi) and a B cell leukemia/lymphoma...

  • Communication
  • Open Access
1 Citations
1,298 Views
8 Pages

6 February 2025

Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, poses significant diagnostic challenges due to its overlap with benign inflammatory skin diseases and the absence of specific symptoms. Accurate early diagnosis and stratifica...

  • Review
  • Open Access
4 Citations
3,339 Views
21 Pages

Biomarkers for the Evaluation of Immunotherapy in Patients with Cholangiocarcinoma

  • Thaleia-Eleftheria Bousou,
  • Panagiotis Sarantis,
  • Ioanna A. Anastasiou,
  • Eleni-Myrto Trifylli,
  • Dimitris Liapopoulos,
  • Dimitra Korakaki,
  • Evangelos Koustas,
  • Michalis Katsimpoulas and
  • Michalis V. Karamouzis

6 February 2025

Cholangiocarcinoma is a rare primary liver cancer with poor prognosis, due to the advanced stage at the time of diagnosis and limited therapeutic options, with poor response. Chemotherapy remains the standard first-line treatment, but the advent of i...

  • Article
  • Open Access
2,001 Views
15 Pages

6 February 2025

Background/Objectives: We aimed to compare the salivary gland volume changes following intensity-modulated radiation therapy (IMRT) alone versus IMRT/intensity-modulated proton therapy (IMPT) combination in oropharyngeal cancer (OPC). Methods: We ret...

  • Article
  • Open Access
3 Citations
1,895 Views
16 Pages

Untargeted Metabolomics and Liquid Biopsy Investigation of Circulating Biomarkers in Soft Tissue Sarcoma

  • Daniela Grasso,
  • Barbara Marzocchi,
  • Guido Scoccianti,
  • Ilaria Palchetti,
  • Domenico Andrea Campanacci,
  • Lorenzo Antonuzzo,
  • Federico Scolari,
  • Serena Pillozzi and
  • Andrea Bernini

6 February 2025

Background: Soft tissue sarcomas (STSs) are rare, highly malignant mesenchymal tumours, comprising approximately 1% of all adult cancers and about 15% of paediatric solid tumours. STSs exhibit considerable genomic complexity with diverse subtypes, po...

  • Article
  • Open Access
2 Citations
2,066 Views
17 Pages

Predictors of the Development of Gastric Cancer in Post-Helicobacter pylori-Eradication Patients Followed Up for More than 10 Years: A Histological, Serological, and Endoscopic Study

  • Kazuhiro Mizukami,
  • Masaaki Kodama,
  • Yuka Hirashita,
  • Masahide Fukuda,
  • Sotaro Ozaka,
  • Koshiro Tsutsumi,
  • Ryota Sagami,
  • Kensuke Fukuda,
  • Ryo Ogawa and
  • Kazunari Murakami

6 February 2025

Background/Objectives: Although Helicobacter pylori (H. pylori) eradication therapy is important for preventing gastric cancer (GC), the occurrence of GC after H. pylori eradication remains a problem. In this study, the aim was to identify risk facto...

  • Article
  • Open Access
1,509 Views
12 Pages

Periostin from Tumor Stromal Cells Might Be Associated with Malignant Progression of Colorectal Cancer via Smad2/3

  • Canfeng Fan,
  • Qiang Wang,
  • Saki Kanei,
  • Kyoka Kawabata,
  • Hinano Nishikubo,
  • Rika Aoyama,
  • Zhonglin Zhu,
  • Daiki Imanishi,
  • Takashi Sakuma and
  • Koji Maruo
  • + 4 authors

6 February 2025

Background/Objectives: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment have been reported to be closely associated with tumor progression in various types of cancer, including colorectal cancer (CRC). Periostin, a matricellular pro...

  • Article
  • Open Access
1 Citations
1,970 Views
12 Pages

Efficacy and Safety of the Topotecan–Cyclophosphamide Regimen in Adult Metastatic Ewing Sarcoma: A Large, Multicenter, Real-World Study

  • Salih Tunbekici,
  • Haydar Cagatay Yuksel,
  • Caner Acar,
  • Gokhan Sahin,
  • Oguzcan Kınıkoglu,
  • Nargiz Majidova,
  • Mustafa Alperen Tunç,
  • Mürsel Sali,
  • Adem Deligonul and
  • Berkan Karadurmus
  • + 4 authors

6 February 2025

Background/Objectives: There is an unmet need to improve outcomes in patients with metastatic Ewing sarcoma (ES). This retrospective, multicenter study aimed to evaluate the efficacy and safety of the topotecan–cyclophosphamide (TC) regimen in...

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Cancers - ISSN 2072-6694