Clinical and Translational Research in Gastrointestinal Cancers (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1145

Special Issue Editors


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Guest Editor
HPB Unit, Flinders Medical Centre & Flinders University, Adelaide 5001, Australia
Interests: pancreatic cancer; outcomes; translational research
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Guest Editor
Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120 Halle, Germany
Interests: abdominal surgery; radiation therapy; anesthesiology; hepatobiliary and pancreatic surgery
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Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of “Clinical and Translational Research in Gastrointestinal Cancers”.

Gastrointestinal (GI) cancers pose a major challenge to global public health. In 2018, Arnold and colleagues (PMID: 32247694) estimated that there were 4.8 million new cases of GI cancers and 3.4 million related deaths worldwide. Lu and colleagues (PMID: 34563100) have recently quantified the involvement of lifestyle-related factors in the development of GI cancers. There remain many options for the primary and secondary prevention of these cancers, and their management is also evolving. Minimally invasive (laparoscopic and robotic) surgery is increasingly applied to complement open surgery. Chemotherapy and radiation therapy have not extended the duration of disease-free survival, but have also had a significant impact on overall survival. The last decade has witnessed a paradigm shift, with a growing interest in cancer survivorship and quality of life. This Special Issue aims to bring together original research and impactful reviews from around the world that highlight developments in the management of a broad spectrum of GI cancers, including survivorship.

Dr. Savio Barreto
Prof. Dr. Jörg Kleeff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgery
  • chemotherapy
  • radiation therapy
  • outcomes
  • quality of life
  • survival
  • survivorship
  • biomarkers
  • imaging

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Research

20 pages, 1338 KiB  
Article
Right-Sided Versus Left-Sided Colon Cancer—A 5-Year Single-Center Observational Study
by Julia Szostek, Michał Serafin, Magdalena Mąka, Beata Jabłońska and Sławomir Mrowiec
Cancers 2025, 17(3), 537; https://doi.org/10.3390/cancers17030537 - 5 Feb 2025
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Abstract
Background: Global colorectal cancer (CRC) incidence is significant, constituting 15% of all cancer cases with 1.4 million new diagnoses annually. Recent research suggests categorizing CRC into three clinical groups: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer, each with distinct [...] Read more.
Background: Global colorectal cancer (CRC) incidence is significant, constituting 15% of all cancer cases with 1.4 million new diagnoses annually. Recent research suggests categorizing CRC into three clinical groups: right colon cancer (RCC), left colon cancer (LCC), and rectal cancer, each with distinct embryological and molecular characteristics. Methods: A retrospective analysis of 189 patients (103 men, 86 women) undergoing surgery for RCC and LCC from January 2018 to December 2023 was performed. Results: LCC was a more common localization (98, 51.85%) than RCC (91, 48.15%). Patients with RCC were older than patients with LCC (70 (36–92, IQR 11) vs. 68 (38–84, IQR 12.5) years; p = 0.02). The duration of surgical procedure was comparable in both groups (225 (120–420, IQR 80) vs. 210 (105–505, IQR 85) minutes; p = 0.16). Complications occurred in 16 (17.58%) patients with RCC and in 15 (15.31%) patients with LCC (p = 0.72). One-year overall survival was 92.76% (SE 2.16%) (91.57% (SE 3.43%) in the RCC group and 93.99% (SE 2.61%) in the LCC group; p = 0.79). Conclusions: Colon cancer incidence is increasing globally due to economic and lifestyle factors. Our study reflects this trend, noting a rise in cases from 2018 to 2023. Despite several differences, overall survival rates do not significantly differ between RCC and LCC patients. Understanding clinical disparities is crucial for optimizing patient outcomes. Full article
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