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Cancers, Volume 15, Issue 4

February-2 2023 - 357 articles

Cover Story: While the incidence of late-onset colorectal cancer (LOCRC) has steadily decreased, the incidence of early-onset colorectal cancer (EOCRC) has continued to increase in the US. This study aims to uncover geographic disparities in EOCRC and understand how risk factors between EOCRC and LOCRC differ. The geographic analysis revealed regions with relatively low LOCRC rates and high EOCRC rates, identifying regions with a disproportionate burden of EOCRC. We then compared community-level risk factors associated with incidence rates of EOCRC and LOCRC using the random forest method. The analysis identified risk factors most predictive of EOCRC and LOCRC, such as diabetes prevalence for EOCRC and physical inactivity for LOCRC. These findings can help to facilitate future studies to further uncover actionable interventions to reduce EOCRC. View this paper
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Articles (357)

  • Article
  • Open Access
8 Citations
3,052 Views
18 Pages

Development of Deep Learning with RDA U-Net Network for Bladder Cancer Segmentation

  • Ming-Chan Lee,
  • Shao-Yu Wang,
  • Cheng-Tang Pan,
  • Ming-Yi Chien,
  • Wei-Ming Li,
  • Jin-Hao Xu,
  • Chi-Hung Luo and
  • Yow-Ling Shiue

20 February 2023

In today’s high-order health examination, imaging examination accounts for a large proportion. Computed tomography (CT), which can detect the whole body, uses X-rays to penetrate the human body to obtain images. Its presentation is a high-resol...

  • Article
  • Open Access
14 Citations
3,687 Views
19 Pages

Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated

  • Alexandra McLean Stevens,
  • Eric S. Schafer,
  • Minhua Li,
  • Maci Terrell,
  • Raushan Rashid,
  • Hana Paek,
  • Melanie B. Bernhardt,
  • Allison Weisnicht,
  • Wesley T. Smith and
  • Noah J. Keogh
  • + 13 authors

20 February 2023

Survival of pediatric AML remains poor despite maximized myelosuppressive therapy. The pneumocystis jiroveci pneumonia (PJP)-treating medication atovaquone (AQ) suppresses oxidative phosphorylation (OXPHOS) and reduces AML burden in patient-derived x...

  • Review
  • Open Access
30 Citations
6,000 Views
22 Pages

DNA Methylation and Histone Modification in Low-Grade Gliomas: Current Understanding and Potential Clinical Targets

  • Ahmad Ozair,
  • Vivek Bhat,
  • Reid S. Alisch,
  • Atulya A. Khosla,
  • Rupesh R. Kotecha,
  • Yazmin Odia,
  • Michael W. McDermott and
  • Manmeet S. Ahluwalia

20 February 2023

Gliomas, the most common type of malignant primary brain tumor, were conventionally classified through WHO Grades I–IV (now 1–4), with low-grade gliomas being entities belonging to Grades 1 or 2. While the focus of the WHO Classification...

  • Article
  • Open Access
5 Citations
2,772 Views
12 Pages

20 February 2023

Background: This study aims to investigate the diagnostic efficacy of radiologists when reading screening mammograms in the absence of previous images, and with the presence of prior images from the same and different vendors. Methods: 612 radiologis...

  • Article
  • Open Access
3 Citations
3,359 Views
12 Pages

Blood–Brain Barrier Disruption (BBBD)-Based Immunochemotherapy for Primary Central Nervous System Lymphoma (PCNSL), Early Results of a Phase II Study

  • Hanne K. Kuitunen,
  • Aino L. K. Rönkä,
  • Eila M. Sonkajärvi,
  • Juha-Matti Isokangas,
  • Marja Pyörälä,
  • Kari A. A. Palosaari,
  • Anna S. Jokimäki,
  • Anu E. Partanen,
  • Harri J. Littow and
  • Merja A. Vakkala
  • + 8 authors

20 February 2023

Primary central nervous system lymphoma is a rare but aggressive brain malignancy. It is associated with poor prognosis even with the current standard of care. The aim of this study was to evaluate the effect and tolerability of blood–brain bar...

  • Article
  • Open Access
10 Citations
3,237 Views
13 Pages

Treatment Pathways and Prognosis in Advanced Sarcoma with Peritoneal Sarcomatosis

  • Fabian Klingler,
  • Hany Ashmawy,
  • Lena Häberle,
  • Irene Esposito,
  • Lars Schimmöller,
  • Wolfram Trudo Knoefel and
  • Andreas Krieg

20 February 2023

Sarcomas represent a heterogeneous group of mesenchymal malignancies that most commonly occur in the extremities, retroperitoneum, and head and neck. Intra-abdominal manifestations are rare and prove particularly difficult to treat when peritoneal sa...

  • Article
  • Open Access
6 Citations
3,621 Views
10 Pages

Safety of Cryopreserved Stem Cell Infusion through a Peripherally Inserted Central Venous Catheter

  • Sławomir Milczarek,
  • Piotr Kulig,
  • Alina Zuchmańska,
  • Bartłomiej Baumert,
  • Bogumiła Osękowska,
  • Anna Bielikowicz,
  • Ewa Wilk-Milczarek and
  • Bogusław Machaliński

20 February 2023

The management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion of blood products, and collection of blood samples. Peripherall...

  • Article
  • Open Access
7 Citations
3,082 Views
24 Pages

20 February 2023

Targeting PI3Kδ has emerged as a promising therapy for hematologic and non-hematologic malignancies. Previously, we identified an oncogenic splice variant, PIK3CD-S, conferring Idelalisib resistance in African American (AA) prostate cancer (PCa...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,534 Views
13 Pages

A Contemporary Report of Low-Dose-Rate Brachytherapy for Prostate Cancer Using MRI for Risk Stratification: Disease Outcomes and Patient-Reported Quality of Life

  • Mira Patel,
  • William Tyler Turchan,
  • Christopher G. Morris,
  • Dana Augustine,
  • Tianming Wu,
  • Aytek Oto,
  • Gregory P. Zagaja and
  • Stanley L. Liauw

20 February 2023

Purpose: We examined a prospective consecutive cohort of low dose rate (LDR) brachytherapy for prostate cancer to evaluate the efficacy of monotherapy for unfavorable-intermediate risk (UIR) disease, and explore factors associated with toxicity and q...

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Cancers - ISSN 2072-6694