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Cancers, Volume 15, Issue 4

February-2 2023 - 357 articles

Cover Story: While the incidence of late-onset colorectal cancer (LOCRC) has steadily decreased, the incidence of early-onset colorectal cancer (EOCRC) has continued to increase in the US. This study aims to uncover geographic disparities in EOCRC and understand how risk factors between EOCRC and LOCRC differ. The geographic analysis revealed regions with relatively low LOCRC rates and high EOCRC rates, identifying regions with a disproportionate burden of EOCRC. We then compared community-level risk factors associated with incidence rates of EOCRC and LOCRC using the random forest method. The analysis identified risk factors most predictive of EOCRC and LOCRC, such as diabetes prevalence for EOCRC and physical inactivity for LOCRC. These findings can help to facilitate future studies to further uncover actionable interventions to reduce EOCRC. View this paper
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Articles (357)

  • Review
  • Open Access
9 Citations
3,832 Views
15 Pages

Occupational Cancers among Employed Women: A Narrative Review

  • Federica Teglia,
  • Giulia Collatuzzo and
  • Paolo Boffetta

20 February 2023

The facts that occupational cancer in women is under-investigated, with few in-depth analyses are well known. In recent decades the workforce has changed, with an increasing number of women employed. Therefore, the inclusion of women in occupational...

  • Review
  • Open Access
9 Citations
9,267 Views
24 Pages

20 February 2023

Cervical cancer (CC) is the fourth most common cancer in women worldwide, with more than 500,000 new cases each year and a mortality rate of around 55%. Over 80% of these deaths occur in developing countries. The most important risk factor for CC is...

  • Review
  • Open Access
15 Citations
5,212 Views
19 Pages

20 February 2023

Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas and is associated with an extremely poor prognosis. Many PDAC patients suffer from profound nutritional complications such as nutrient deficiencies, weight loss, ma...

  • Review
  • Open Access
5 Citations
4,675 Views
17 Pages

20 February 2023

In the case of small-cell lung carcinoma, the highly metastatic nature of the disease and the propensity for several chromatin modifiers to harbor mutations suggest that epigenetic manipulation may also be a promising route for oncotherapy, but histo...

  • Article
  • Open Access
7 Citations
7,476 Views
14 Pages

Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells

  • Natalie S. Joe,
  • Yuanfeng Wang,
  • Harsh H. Oza,
  • Inês Godet,
  • Nubaira Milki,
  • Gregory J. Riggins and
  • Daniele M. Gilkes

20 February 2023

Breast cancer is the most diagnosed cancer in women in the world. Mebendazole (MBZ) has been demonstrated to have preclinical efficacy across multiple cancers, including glioblastoma multiforme, medulloblastoma, colon, breast, pancreatic, and thyroid...

  • Article
  • Open Access
15 Citations
3,832 Views
19 Pages

Nano-Electrochemical Characterization of a 3D Bioprinted Cervical Tumor Model

  • Maila Becconi,
  • Simona De Zio,
  • Francesco Falciani,
  • Marzia Santamaria,
  • Marco Malferrari and
  • Stefania Rapino

19 February 2023

Current cancer research is limited by the availability of reliable in vivo and in vitro models that are able to reproduce the fundamental hallmarks of cancer. Animal experimentation is of paramount importance in the progress of research, but it is be...

  • Article
  • Open Access
13 Citations
4,147 Views
13 Pages

Prognostic Factors in Pseudomyxoma Peritonei with Emphasis on the Predictive Role of Peritoneal Cancer Index and Tumor Markers

  • Sebastian Blaj,
  • David Dora,
  • Zoltan Lohinai,
  • Zoltan Herold,
  • Attila Marcell Szasz,
  • Jonas Herzberg,
  • Roland Kodacsi,
  • Saher Baransi,
  • Hans Jürgen Schlitt and
  • Matthias Hornung
  • + 4 authors

19 February 2023

Background: Pseudomyxoma peritonei (PMP) is a rare peritoneal condition where mucus-secreting tumorous cells progressively produce a thick, gelatin-like substance. The prognosis of patients with PMP is determined by the degree of cellularity within t...

  • Article
  • Open Access
14 Citations
3,411 Views
15 Pages

The Value of Multiparametric Magnetic Resonance Imaging in the Preoperative Differential Diagnosis of Parotid Gland Tumors

  • Sebastian Stoia,
  • Manuela Lenghel,
  • Cristian Dinu,
  • Tiberiu Tamaș,
  • Simion Bran,
  • Mihaela Băciuț,
  • Emil Boțan,
  • Daniel Leucuța,
  • Gabriel Armencea and
  • Florin Onișor
  • + 1 author

19 February 2023

Background: The aim of the present study was to determine the value of multiparametric MRI in the preoperative differential diagnosis of parotid tumors, which is essential for therapeutic strategy selection. Methods: A three-year prospective study wa...

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Cancers - ISSN 2072-6694