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Cancers, Volume 15, Issue 4

February-2 2023 - 357 articles

Cover Story: While the incidence of late-onset colorectal cancer (LOCRC) has steadily decreased, the incidence of early-onset colorectal cancer (EOCRC) has continued to increase in the US. This study aims to uncover geographic disparities in EOCRC and understand how risk factors between EOCRC and LOCRC differ. The geographic analysis revealed regions with relatively low LOCRC rates and high EOCRC rates, identifying regions with a disproportionate burden of EOCRC. We then compared community-level risk factors associated with incidence rates of EOCRC and LOCRC using the random forest method. The analysis identified risk factors most predictive of EOCRC and LOCRC, such as diabetes prevalence for EOCRC and physical inactivity for LOCRC. These findings can help to facilitate future studies to further uncover actionable interventions to reduce EOCRC. View this paper
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Articles (357)

  • Article
  • Open Access
5 Citations
3,365 Views
17 Pages
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HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer

  • Yiling Li,
  • Kexin Li,
  • Xiaoying Lou,
  • Yue Wu,
  • Samuel Seery,
  • Danfei Xu,
  • Yuqing Pei,
  • Benheng Qian,
  • Yuxin Wu and
  • Shuang Liang
  • + 2 authors
Cancers2023, 15(4), 1367;https://doi.org/10.3390/cancers15051367

21 February 2023

MicroRNA-92a (miR-92a) may serve as a novel promising biomarker in multiple cancers, including colorectal cancer (CRC); however, the diagnostic accuracy and the underlying molecular mechanism of miR-92a in CRC is poorly understood. We first carried o...

Full Article
  • Review
  • Open Access
10 Citations
4,211 Views
20 Pages
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Use of Telemedicine to Improve Cognitive Functions and Psychological Well-Being in Patients with Breast Cancer: A Systematic Review of the Current Literature

  • Andreina Giustiniani,
  • Laura Danesin,
  • Rachele Pezzetta,
  • Fabio Masina,
  • Giulia Oliva,
  • Giorgio Arcara,
  • Francesca Burgio and
  • Pierfranco Conte
Cancers2023, 15(4), 1353;https://doi.org/10.3390/cancers15041353

20 February 2023

The diagnosis and side effects of breast cancer (BC) treatments greatly affect the everyday lives of women suffering from this disease, with relevant psychological and cognitive consequences. Several studies have reported the psychological effects of...

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  • Article
  • Open Access
15 Citations
3,676 Views
19 Pages
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Canine-Inspired Chemometric Analysis of Volatile Organic Compounds in Urine Headspace to Distinguish Prostate Cancer in Mice and Men

  • Mark Woollam,
  • Amanda P. Siegel,
  • Adam Munshi,
  • Shengzhi Liu,
  • Sunil Tholpady,
  • Thomas Gardner,
  • Bai-Yan Li,
  • Hiroki Yokota and
  • Mangilal Agarwal
Cancers2023, 15(4), 1352;https://doi.org/10.3390/cancers15041352

20 February 2023

Canines can identify prostate cancer with high accuracy by smelling volatile organic compounds (VOCs) in urine. Previous studies have identified VOC biomarkers for prostate cancer utilizing solid phase microextraction (SPME) gas chromatography–...

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  • Article
  • Open Access
5 Citations
2,855 Views
12 Pages
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Measuring the Wellbeing of Cancer Patients with Generic and Disease-Specific Instruments

  • Gang Chen,
  • Norma B. Bulamu,
  • Ellen McGrane and
  • Jeff Richardson
Cancers2023, 15(4), 1351;https://doi.org/10.3390/cancers15041351

20 February 2023

Different wellbeing measures have been used among cancer patients. This study aimed to first investigate the sensitivity of health state utility (HSU), capability, and subjective wellbeing (SWB) instruments in cancer. A cancer-specific instrument (QL...

Full Article
  • Review
  • Open Access
5 Citations
3,809 Views
23 Pages
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Optimal Use of Novel Immunotherapeutics in B-Cell Precursor ALL

  • Federico Lussana,
  • Gianluca Cavallaro,
  • Pantaleo De Simone and
  • Alessandro Rambaldi
Cancers2023, 15(4), 1349;https://doi.org/10.3390/cancers15041349

20 February 2023

Novel immune therapies are currently being used for patients with R/R ALL based on their ability to induce not only hematologic but also molecular remission. Despite promising results, specific clinical conditions, such as high tumor burden or extra...

Full Article
  • Review
  • Open Access
5 Citations
3,094 Views
19 Pages
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Deepening Our Understanding of the Factors Affecting Landscape of Myeloproliferative Neoplasms: What Do We Know about Them?

  • María Luz Morales and
  • Francisca Ferrer-Marín
Cancers2023, 15(4), 1348;https://doi.org/10.3390/cancers15041348

20 February 2023

Myeloproliferative neoplasms (MPNs) arise from the uncontrolled proliferation of hematopoietic stem and progenitor cells in bone marrow. As with all tumors, the development of MPNs is a consequence of alterations in malignant cells and their interact...

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  • Article
  • Open Access
11 Citations
2,628 Views
13 Pages
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Variation in Post-Transplant Cancer Incidence among Italian Kidney Transplant Recipients over a 25-Year Period

  • Pierluca Piselli,
  • Diego Serraino,
  • Claudia Cimaglia,
  • Lucrezia Furian,
  • Luigi Biancone,
  • Ghil Busnach,
  • Nicola Bossini,
  • Paola Todeschini,
  • Maurizio Iaria and
  • Franco Citterio
  • + 11 authors
Cancers2023, 15(4), 1347;https://doi.org/10.3390/cancers15041347

20 February 2023

This cohort study examined 25-year variations in cancer incidence among 11,418 Italian recipients of kidney transplantation (KT) from 17 Italian centers. Cancer incidence was examined over three periods (1997–2004; 2005–2012; and 2013&nda...

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  • Review
  • Open Access
2 Citations
4,312 Views
20 Pages
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Prognostic and Predictive Biomarkers in Familial Breast Cancer

  • Siddhartha Deb,
  • Anannya Chakrabarti and
  • Stephen B. Fox
Cancers2023, 15(4), 1346;https://doi.org/10.3390/cancers15041346

20 February 2023

Large numbers of breast cancers arise within a familial context, either with known inherited germline mutations largely within DNA repair genes, or with a strong family history of breast and/or ovarian cancer, with unknown genetic underlying mechanis...

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  • Article
  • Open Access
2,543 Views
11 Pages
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Replacement Instead of Discontinuation of Bacillus Calmette-Guérin Instillation in Non-Muscle-Invasive Bladder Cancer

  • Po-Ting Lin,
  • Wei-Kang Hung,
  • Ying-Hsu Chang,
  • Ming-Li Hsieh,
  • Chung-Yi Liu,
  • Liang-Kang Huang,
  • Yuan-Cheng Chu,
  • Hung-Cheng Kan,
  • Po-Hung Lin and
  • Kai-Jie Yu
  • + 4 authors
Cancers2023, 15(4), 1345;https://doi.org/10.3390/cancers15041345

20 February 2023

Background: To evaluate the efficacy of intravesical chemotherapy replacement in patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC), who underwent bacillus Calmette-Guérin (BCG) instillation but discontinued d...

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