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Cancers, Volume 14, Issue 8

2022 April-2 - 194 articles

Cover Story: Given the importance of the epithelial-to-mesenchymal transition in tumor progression and the pivotal role of ZEB1 as a transcriptional repressor during this process, the regulation of ZEB1-targeted gene expression is an active area of investigation. Diverse signaling pathways converge to induce ZEB1 activity, but few studies have focused on the enzyme-dependent modifications of ZEB1 that occur after its translation from mRNA (i.e., post-translational modifications, PTM). In addition to outlining the current knowledge in the field, we outline several questions regarding the PTM-mediated regulation of ZEB1 that remain unanswered. Thus, the areas of research covered in this review paper will enhance the development of treatment strategies by identifying knowledge gaps in ZEB1′s regulatory mechanisms that could potentially be targeted to prevent and treat metastasis in cancer patients. View this paper
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Articles (194)

  • Article
  • Open Access
4 Citations
2,456 Views
11 Pages

Novel Intraoperative Navigation Using Ultra-High-Resolution CT in Robot-Assisted Partial Nephrectomy

  • Kiyoshi Takahara,
  • Yoshiharu Ohno,
  • Kosuke Fukaya,
  • Ryo Matsukiyo,
  • Takuhisa Nukaya,
  • Masashi Takenaka,
  • Kenji Zennami,
  • Manabu Ichino,
  • Naohiko Fukami and
  • Ryoichi Shiroki
  • + 4 authors

18 April 2022

To assess the perioperative and short-term functional outcomes of robot-assisted partial nephrectomy (RAPN) with intraoperative navigation using an ultra-high-resolution computed tomography (UHR-CT) scanner, we retrospectively analyzed 323 patients w...

  • Article
  • Open Access
7 Citations
3,515 Views
18 Pages

Gene-Mutation-Based Algorithm for Prediction of Treatment Response in Colorectal Cancer Patients

  • Heather Johnson,
  • Zahra El-Schich,
  • Amjad Ali,
  • Xuhui Zhang,
  • Athanasios Simoulis,
  • Anette Gjörloff Wingren and
  • Jenny L. Persson

18 April 2022

Purpose: Despite the high mortality of metastatic colorectal cancer (mCRC), no new biomarker tools are available for predicting treatment response. We developed gene-mutation-based algorithms as a biomarker classifier to predict treatment response wi...

  • Review
  • Open Access
10 Citations
4,424 Views
12 Pages

The Road to Dissemination: The Concept of Oligometastases and the Barriers for Widespread Disease

  • Hamza AlGhamdi,
  • Jennifer Dhont,
  • Mohammad Krayem,
  • Pauline De Bruyn,
  • Benedikt Engels,
  • Dirk Van Gestel and
  • Robbe Van den Begin

18 April 2022

Over the last years, the oligometastatic disease state has gained more and more interest, and randomized trials are now suggesting an added value of stereotactic radiotherapy on all macroscopic disease in oligometastatic patients; but what barriers c...

  • Review
  • Open Access
46 Citations
6,156 Views
20 Pages

How Did Conventional Nanoparticle-Mediated Photothermal Therapy Become “Hot” in Combination with Cancer Immunotherapy?

  • Wan Su Yun,
  • Ji-Ho Park,
  • Dong-Kwon Lim,
  • Cheol-Hee Ahn,
  • In-Cheol Sun and
  • Kwangmeyung Kim

18 April 2022

One of the promising cancer treatment methods is photothermal therapy (PTT), which has achieved good therapeutic efficiency through nanoparticle-based photoabsorbers. Because of the various functions of nanoparticles, such as targeting properties, hi...

  • Article
  • Open Access
14 Citations
3,083 Views
11 Pages

Breast Tumor Identification in Ultrafast MRI Using Temporal and Spatial Information

  • Xueping Jing,
  • Monique D. Dorrius,
  • Mirjam Wielema,
  • Paul E. Sijens,
  • Matthijs Oudkerk and
  • Peter van Ooijen

18 April 2022

Purpose: To investigate the feasibility of using deep learning methods to differentiate benign from malignant breast lesions in ultrafast MRI with both temporal and spatial information. Methods: A total of 173 single breasts of 122 women (151 examina...

  • Article
  • Open Access
27 Citations
6,647 Views
16 Pages

Integrated Network Pharmacology Approach for Drug Combination Discovery: A Multi-Cancer Case Study

  • Antonio Federico,
  • Michele Fratello,
  • Giovanni Scala,
  • Lena Möbus,
  • Alisa Pavel,
  • Giusy del Giudice,
  • Michele Ceccarelli,
  • Valerio Costa,
  • Alfredo Ciccodicola and
  • Dario Greco
  • + 2 authors

18 April 2022

Despite remarkable efforts of computational and predictive pharmacology to improve therapeutic strategies for complex diseases, only in a few cases have the predictions been eventually employed in the clinics. One of the reasons behind this drawback...

  • Article
  • Open Access
19 Citations
4,399 Views
15 Pages

Multi-Omics Approach Points to the Importance of Oxylipins Metabolism in Early-Stage Breast Cancer

  • Dmitry V. Chistyakov,
  • Mariia V. Guryleva,
  • Elena S. Stepanova,
  • Lyubov M. Makarenkova,
  • Elena V. Ptitsyna,
  • Sergei V. Goriainov,
  • Arina I. Nikolskaya,
  • Alina A. Astakhova,
  • Anna S. Klimenko and
  • Marina G. Sergeeva
  • + 5 authors

18 April 2022

The involvement of oxylipins, metabolites of polyunsaturated fatty acids, in cancer pathogenesis was known long ago, but only the development of the high-throughput methods get the opportunity to study oxylipins on a system level. The study aimed to...

  • Review
  • Open Access
11 Citations
4,962 Views
24 Pages

Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia

  • Tafadzwa Chihanga,
  • Sara Vicente-Muñoz,
  • Sonya Ruiz-Torres,
  • Bidisha Pal,
  • Mathieu Sertorio,
  • Paul R. Andreassen,
  • Ruby Khoury,
  • Parinda Mehta,
  • Stella M. Davies and
  • Susanne I. Wells
  • + 2 authors

18 April 2022

Fanconi anemia (FA) is a rare inherited, generally autosomal recessive syndrome, but it displays X-linked or dominant negative inheritance for certain genes. FA is characterized by a deficiency in DNA damage repair that results in bone marrow failure...

  • Article
  • Open Access
7 Citations
2,923 Views
13 Pages

Implication of COPB2 Expression on Cutaneous Squamous Cell Carcinoma Pathogenesis

  • Taiqin Chen,
  • Ki-Yeol Kim,
  • Yeongjoo Oh,
  • Hei Cheul Jeung,
  • Kee Yang Chung,
  • Mi Ryung Roh and
  • Xianglan Zhang

18 April 2022

The underlying molecular mechanisms of cutaneous squamous cell carcinoma (cSCC) pathogenesis are largely unknown. In the present study, we aimed to evaluate the effect of coatomer protein complex subunit beta 2 (COPB2) expression on cSCC pathogenesis...

  • Review
  • Open Access
17 Citations
4,848 Views
17 Pages

The Implication of Gastric Microbiome in the Treatment of Gastric Cancer

  • George Pappas-Gogos,
  • Kostas Tepelenis,
  • Fotis Fousekis,
  • Konstantinos Katsanos,
  • Michail Pitiakoudis and
  • Konstantinos Vlachos

18 April 2022

Gastric cancer (GC) is one of the most common and deadly malignancies worldwide. Helicobacter pylori have been documented as a risk factor for GC. The development of sequencing technology has broadened the knowledge of the gastric microbiome, which i...

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Cancers - ISSN 2072-6694