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Cancers, Volume 14, Issue 24

December-2 2022 - 251 articles

Cover Story: Androgen deprivation therapy (ADT) is the principal therapy for advanced prostate cancer. ADT controls tumor growth by rapidly altering the prostate tumor microenvironment and subsequently inducing cancer cell death. ADT induces vascular damage and thereby reduces intratumoral blood flow, but the mechanism has long been elusive. This work, for the first time, functionally defines TNF as the mediator of castration-induced vascular damage in prostate tumors. This pathological response to androgen deprivation—beginning with endothelial cell apoptosis and increased vessel permeability and culminating in hypoxia—indirectly contributes to prostate cancer regression. Since TNF is also a critical death receptor ligand for prostate epithelial cells, we propose that TNF is a multi-purpose, comprehensive signal that mediates prostate cancer regression following androgen deprivation. View this paper
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Articles (251)

  • Review
  • Open Access
6 Citations
3,590 Views
11 Pages

Best Supportive Care of the Patient with Oesophageal Cancer

  • Rita Carrilho Pichel,
  • Alexandra Araújo,
  • Vital Da Silva Domingues,
  • Jorge Nunes Santos,
  • Elga Freire,
  • Ana Sofia Mendes,
  • Raquel Romão and
  • António Araújo

19 December 2022

Background: Oesophageal cancer patients have poor survival, and most are unfit for curative or systemic palliative treatment. This article aims to review the best supportive care for oesophageal cancer, focusing on the management of its most frequent...

  • Review
  • Open Access
19 Citations
4,581 Views
18 Pages

19 December 2022

Breast cancer (BC) is a heterogeneous disease that can be triggered by genetic alterations in mammary epithelial cells, leading to diverse disease outcomes in individual patients. The metabolic heterogeneity of BC enhances its ability to adapt to cha...

  • Article
  • Open Access
3 Citations
2,641 Views
16 Pages

Development and Psychometric Evaluation of Healthcare Access Measures among Women with Ovarian Cancer

  • Tomi Akinyemiju,
  • Ashwini Joshi,
  • April Deveaux,
  • Lauren E. Wilson,
  • Dandan Chen,
  • Clare Meernik,
  • Malcolm Bevel,
  • Jen Gathings,
  • Laura Fish and
  • Nadine Barrett
  • + 12 authors

19 December 2022

Several proposed theoretical frameworks have defined the complex nature of healthcare access (HCA) [...]

  • Review
  • Open Access
11 Citations
2,974 Views
21 Pages

A Multi-Disciplinary Approach to Diagnosis and Treatment of Radionecrosis in Malignant Gliomas and Cerebral Metastases

  • Julian Mangesius,
  • Stephanie Mangesius,
  • Matthias Demetz,
  • Christian Uprimny,
  • Gianpaolo Di Santo,
  • Malik Galijasevic,
  • Danijela Minasch,
  • Elke R. Gizewski,
  • Ute Ganswindt and
  • Irene Virgolini
  • + 3 authors

19 December 2022

Radiation necrosis represents a potentially devastating complication after radiation therapy in brain tumors. The establishment of the diagnosis and especially the differentiation from progression and pseudoprogression with its therapeutic implicatio...

  • Review
  • Open Access
10 Citations
2,873 Views
10 Pages

19 December 2022

Intrahepatic cholangiocarcinoma (ICC) is a rare and aggressive malignancy. It originates from the bile ducts and is the second most common primary cancer of the liver. Surgery is considered the only curative treatment of ICC, offering the best chance...

  • Article
  • Open Access
3,028 Views
16 Pages

Comparing Genetic Risk and Clinical Risk Classification in Luminal-like Breast Cancer Patients Using a 23-Gene Classifier

  • Chi-Cheng Huang,
  • Ting-Hao Chen,
  • Liang-Chih Liu,
  • Chiun-Sheng Huang,
  • Ji-An Liang,
  • Yu-Chen Hsu,
  • Chia-Ming Hsieh,
  • Sean-Lin Huang,
  • Kuan-Hui Shih and
  • Ling-Ming Tseng

19 December 2022

Background: A 23-gene classifier has been developed based on gene expression profiles of Taiwanese luminal-like breast cancer. We aim to stratify risk of relapse and identify patients who may benefit from adjuvant chemotherapy based on genetic model...

  • Article
  • Open Access
19 Citations
3,876 Views
21 Pages

A Label-Free Proteomic Approach for the Identification of Biomarkers in the Exosome of Endometrial Cancer Serum

  • Eduardo Sommella,
  • Valeria Capaci,
  • Michelangelo Aloisio,
  • Emanuela Salviati,
  • Pietro Campiglia,
  • Giuseppe Molinario,
  • Danilo Licastro,
  • Giovanni Di Lorenzo,
  • Federico Romano and
  • Giuseppe Ricci
  • + 2 authors

19 December 2022

Endometrial cancers (ECs) are mostly adenocarcinomas arising from the inner part of the uterus. The identification of serum biomarkers, either soluble or carried in the exosome, may be useful in making an early diagnosis. We used label-free quantific...

  • Article
  • Open Access
9 Citations
2,750 Views
13 Pages

Integration of Clinical and CT-Based Radiomic Features for Pretreatment Prediction of Pathologic Complete Response to Neoadjuvant Systemic Therapy in Breast Cancer

  • Huei-Yi Tsai,
  • Tsung-Yu Tsai,
  • Chia-Hui Wu,
  • Wei-Shiuan Chung,
  • Jo-Ching Wang,
  • Jui-Sheng Hsu,
  • Ming-Feng Hou and
  • Ming-Chung Chou

19 December 2022

The purpose of the present study was to examine the potential of a machine learning model with integrated clinical and CT-based radiomics features in predicting pathologic complete response (pCR) to neoadjuvant systemic therapy (NST) in breast cancer...

  • Review
  • Open Access
20 Citations
6,088 Views
33 Pages

Kinase Inhibitors in the Treatment of Ovarian Cancer: Current State and Future Promises

  • Aikaterini Skorda,
  • Marie Lund Bay,
  • Sampsa Hautaniemi,
  • Alexandra Lahtinen and
  • Tuula Kallunki

19 December 2022

Ovarian cancer is the deadliest gynecological cancer, the high-grade serous ovarian carcinoma (HGSC) being its most common and most aggressive form. Despite the latest therapeutical advancements following the introduction of vascular endothelial grow...

  • Article
  • Open Access
13 Citations
3,500 Views
19 Pages

Therapeutic Target Identification and Inhibitor Screening against Riboflavin Synthase of Colorectal Cancer Associated Fusobacterium nucleatum

  • Norah A. Alturki,
  • Mutaib M. Mashraqi,
  • Khurshid Jalal,
  • Kanwal Khan,
  • Zarrin Basharat and
  • Ahmad Alzamami

19 December 2022

Colorectal cancer (CRC) ranks third among all cancers in terms of prevalence. There is growing evidence that gut microbiota has a role in the development of colorectal cancer. Fusobacterium nucleatum is overrepresented in the gastrointestinal tract a...

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Cancers - ISSN 2072-6694