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Cancers, Volume 13, Issue 6

March-2 2021 - 299 articles

Cover Story: Pancreatic cancer is among the major lethal cancers, with a dismal five-year survival rate of 5%. The vast majority of pancreatic tumors are pancreatic ductal adenocarcinomas (PDAC), which are characterized by pronounced inflammation. In this issue, Toledano-Fonseca et al. evaluate the prognostic value of combining biomarkers of systemic inflammation with liquid biopsy-based biomarkers. Their study shows that combining the neutrophil-to-lymphocyte-ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and the standard PDAC marker CA19-9 with circulating cell-free DNA and circulating RAS-mutated DNA greatly improves prognostic power and provides accurate survival risk stratification. This work, therefore, supports the use of systemic inflammatory markers along with circulating tumor-specific markers as valuable tools for the clinical management of metastatic PDAC patients. View this paper.
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Articles (299)

  • Article
  • Open Access
15 Citations
4,516 Views
15 Pages

Image-Guided Adaptive Brachytherapy (IGABT) for Primary Vaginal Cancer: Results of the International Multicenter RetroEMBRAVE Cohort Study

  • Henrike Westerveld,
  • Maximilian P. Schmid,
  • Remi A. Nout,
  • Cyrus Chargari,
  • Bradley R. Pieters,
  • Carien L. Creutzberg,
  • Alina Sturdza,
  • Jacob C. Lindegaard,
  • Zdenko van Kesteren and
  • Renaud Mazeron
  • + 2 authors

23 March 2021

Purpose: This study assessed outcomes following the nowadays standing treatment for primary vaginal cancer with radio(chemo)therapy and image-guided adaptive brachytherapy (IGABT) in a multicenter patient cohort. Methods: Patients treated with comput...

  • Article
  • Open Access
9 Citations
3,575 Views
10 Pages

Three-Dimensional Radiological Assessment of Ablative Margins in Hepatocellular Carcinoma: Pilot Study of Overlay Fused CT/MRI Imaging with Automatic Registration

  • Yasunori Minami,
  • Tomohiro Minami,
  • Kazuomi Ueshima,
  • Yukinobu Yagyu,
  • Masakatsu Tsurusaki,
  • Takuya Okada,
  • Masatoshi Hori,
  • Masatoshi Kudo and
  • Takamichi Murakami

23 March 2021

Background: We investigate the feasibility of image fusion application for ablative margin assessment in radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and possible causes for a wrong initial evaluation of technical success through...

  • Article
  • Open Access
20 Citations
3,769 Views
14 Pages

Tracking the Progression of Triple Negative Mammary Tumors over Time by Chemometric Analysis of Urinary Volatile Organic Compounds

  • Mark Woollam,
  • Luqi Wang,
  • Paul Grocki,
  • Shengzhi Liu,
  • Amanda P. Siegel,
  • Maitri Kalra,
  • John V. Goodpaster,
  • Hiroki Yokota and
  • Mangilal Agarwal

23 March 2021

Previous studies have shown that volatile organic compounds (VOCs) are potential biomarkers of breast cancer. An unanswered question is how urinary VOCs change over time as tumors progress. To explore this, BALB/c mice were injected with 4T1.2 triple...

  • Review
  • Open Access
31 Citations
6,159 Views
15 Pages

23 March 2021

Thanks to the growing knowledge about cancers and their interactions with the immune system, a huge number of therapeutic cancer vaccines have been developed in the past two decades. Despite encouraging results in pre-clinical models, cancer vaccines...

  • Article
  • Open Access
20 Citations
3,904 Views
15 Pages

Thyroid Dysfunction in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors (ICIs): Outcomes in a Multiethnic Urban Cohort

  • Angelica D’Aiello,
  • Juan Lin,
  • Rasim Gucalp,
  • Vafa Tabatabaie,
  • Haiying Cheng,
  • Noah A. Bloomgarden,
  • Yaron Tomer and
  • Balazs Halmos

23 March 2021

We sought to characterize thyroid dysfunction and its association with baseline clinical and demographic characteristics, as well as progression-free survival (PFS), in a multiethnic cohort of lung cancer patients treated with ICIs. A retrospective c...

  • Article
  • Open Access
18 Citations
4,442 Views
12 Pages

Role of Repeat PET/CT Imaging in Head and Neck Cancer Following Initial Incomplete PET/CT Response to Chemoradiation

  • Austin J. Iovoli,
  • Mark K. Farrugia,
  • Sung Jun Ma,
  • Jon M. Chan,
  • Michael R. Markiewicz,
  • Ryan McSpadden,
  • Kimberly E. Wooten,
  • Vishal Gupta,
  • Moni A. Kuriakose and
  • Wesley L. Hicks
  • + 1 author

23 March 2021

Despite waiting 13 weeks to perform a PET/CT scan after completion of chemoradiation for head and neck squamous cell carcinoma (HNSCC), equivocal findings are often found that make assessing treatment response difficult. This retrospective study exam...

  • Article
  • Open Access
25 Citations
4,613 Views
19 Pages

Three-Dimensional Tumor Spheroids as a Tool for Reliable Investigation of Combined Gold Nanoparticle and Docetaxel Treatment

  • Kyle Bromma,
  • Abdulaziz Alhussan,
  • Monica Mesa Perez,
  • Perry Howard,
  • Wayne Beckham and
  • Devika B. Chithrani

23 March 2021

Radiotherapy and chemotherapy are the gold standard for treating patients with cancer in the clinic but, despite modern advances, are limited by normal tissue toxicity. The use of nanomaterials, such as gold nanoparticles (GNPs), to improve radiosens...

  • Review
  • Open Access
12 Citations
6,374 Views
19 Pages

In-Depth Characterization of Stromal Cells within the Tumor Microenvironment Yields Novel Therapeutic Targets

  • Sebastian G. Walter,
  • Sebastian Scheidt,
  • Robert Nißler,
  • Christopher Gaisendrees,
  • Kourosh Zarghooni and
  • Frank A. Schildberg

23 March 2021

Cells within the tumor stroma are essential for tumor progression. In particular, cancer-associated fibroblasts (CAF) and CAF precursor cells (resident fibroblasts and mesenchymal stromal cells) are responsible for the formation of the extracellular...

  • Review
  • Open Access
38 Citations
6,257 Views
29 Pages

Charged Particle and Conventional Radiotherapy: Current Implications as Partner for Immunotherapy

  • Damiënne Marcus,
  • Relinde I. Y. Lieverse,
  • Carmen Klein,
  • Amir Abdollahi,
  • Philippe Lambin,
  • Ludwig J. Dubois and
  • Ala Yaromina

23 March 2021

Radiotherapy (RT) has been shown to interfere with inflammatory signals and to enhance tumor immunogenicity via, e.g., immunogenic cell death, thereby potentially augmenting the therapeutic efficacy of immunotherapy. Conventional RT consists predomin...

  • Article
  • Open Access
7 Citations
3,159 Views
16 Pages

Pre-Surgery Cognitive Performance and Voxel-Based Lesion-Symptom Mapping in Patients with Left High-Grade Glioma

  • Ilaria Guarracino,
  • Tamara Ius,
  • Cinzia Baiano,
  • Serena D’Agostini,
  • Miran Skrap and
  • Barbara Tomasino

23 March 2021

(1) Background: The literature on the effects of high-grade glioma (HGG) growth on cognition is still scarce. (2) Method: A consecutive series of 85 patients with HGG involving the left hemisphere underwent an extended neuropsychological evaluation p...

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Cancers - ISSN 2072-6694