Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 14373
Special Issue Editors
Interests: endometrial cancer; ovarian cancer; intraperitoneal chemotherapy; cervical dysplasia
Special Issues, Collections and Topics in MDPI journals
Interests: GI-Cancer Surgery, Peritoneal Metastasis, HIPEC, PIPAC, Aerosol-Technology, Technical Innovations for Intraperitoneal Aerosol Therapy, Small Animal PM Models, Small Animal Cancer Imaging, Clinical Trials
Special Issue Information
Dear Colleagues,
Since several decades, liquid intraperitoneal chemotherapy (LIP) has become an important part of the multimodal treatment approach to patients suffering from peritoneal metastases (PM). In most cases, LIP is delivered as heated liquid intraperitoneal chemotherapy (HIPEC) in combination with cytoreductive surgery. However, clinical data and the exact role of LIP/HIPEC to manage PM patients remain conflicting.
Almost one decade ago, the delivery of intraperitoneal chemotherapy as a pressurized aerosol (PIPAC) has been introduced. Although PIPAC has been rapidly integrated into the daily clinical management of PM patients, there is still a lack of solid preclinical and clinical data. Nevertheless, there are now numerous clinical trials under progress but without a preclinical proof of concept of PIPAC and based on empiric treatment parameters. Therefore, there is a clear need for detailed preclinical data of all aspects about PIPAC technology.
The aim of this Special Issue is to give the reader a deeper inside into ongoing preclinical and clinical research about LIP and PIPAC. A strong focus will be furthermore given to nanotechnology, hydrocolloids and cold plasma technology which will hopefully become new treatment options in the near future to reinforce the fight against this devasting disease.
Prof. Clemens B. Tempfer
Dr. Urs Giger-Pabst
Prof. Mehdi Ouaissi
Guest Editors
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Keywords
- Intraperitoneal Chemotherapy (IPC)
- Peritoneal Metastases (PM)
- HIPEC
- PIPAC
- Intraperitoneal Aerosol Generation Technology
- Granulometry
- Small Animal PM Models
- Small Animal PM Imaging
- PIPAC Animal Models
- In-silico HIPEC/PIPAC Models
- Animal Testing Substitution Models
- Pharmacokinetics
- Nanodrugs
- Hydrocolloids
- Liposomes
- New Drug Development
- Cold Atmospheric Plasma-Activated Solutions
- Clinical Trials
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