Table of Contents
Cancers, Volume 10, Issue 7 (July 2018)
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Cover Story (view full-size image) Oncoviruses are capable of subverting the cell signaling machinery and metabolic pathways and [...] Read more. Oncoviruses are capable of subverting the cell signaling machinery and metabolic pathways and exploit them for infection, replication, and persistence. Some viral oncoproteins are able to directly bind to and degrade p53, others cause the functionally inactivation of the oncosuppressor and deregulated expression of many genes orchestrated by p53. New drugs are being developed to target the interaction between viral oncoproteins and p53, as well as the negative regulators MDM2/MDMX and p53, and are already at the preclinical study stage and early-phase clinical trials. View this paper