Toxins, Volume 9, Issue 12 (December 2017) – 31 articles
Cover Story (view full-size image): Computer-aided design of the bioreceptor for ochratoxin monitoring: In solution, the unmodified bioreceptor (blue) binds to ochratoxin (magenta) with its intrinsic affinity. However, on the biotransducer surface (cyan), the bioreceptor becomes sterically hindered. A hexa-histidine tag (His-tag ) (green) immobilizes the bioreceptor and recovers some of the configurational freedom. However, linking via the amine or acid end alters the mechanism of binding and the efficacy. The configurational freedom is improved by placing a polyethylene glycol (PEG) spacer (red) between the His-tag and bioreceptor. While experimental techniques are limited, computer-aided technologies are promising in a rationalized route to bioreceptor design. View this paper
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