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Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia

Laboratory of Pain and Signaling, Butantan Institute, Av. Vital Brasil, 1500, 05503-900 São Paulo, SP, Brazil
Department of Physics and Biophysics, São Paulo State University (UNESP), Rua Professor Doutor Antonio Celso Wagner Zanin, s/n, 18618-689 Botucatu, SP, Brazil
Authors to whom correspondence should be addressed.
Toxins 2017, 9(12), 406;
Received: 30 October 2017 / Revised: 13 December 2017 / Accepted: 16 December 2017 / Published: 19 December 2017
(This article belongs to the Special Issue Animal Venoms and Pain)
Animal venoms comprise a complex mixture of components that affect several biological systems. Based on the high selectivity for their molecular targets, these components are also a rich source of potential therapeutic agents. Among the main components of animal venoms are the secreted phospholipases A2 (sPLA2s). These PLA2 belong to distinct PLA2s groups. For example, snake venom sPLA2s from Elapidae and Viperidae families, the most important families when considering envenomation, belong, respectively, to the IA and IIA/IIB groups, whereas bee venom PLA2 belongs to group III of sPLA2s. It is well known that PLA2, due to its hydrolytic activity on phospholipids, takes part in many pathophysiological processes, including inflammation and pain. Therefore, secreted PLA2s obtained from animal venoms have been widely used as tools to (a) modulate inflammation and pain, uncovering molecular targets that are implicated in the control of inflammatory (including painful) and neurodegenerative diseases; (b) shed light on the pathophysiology of inflammation and pain observed in human envenomation by poisonous animals; and, (c) characterize molecular mechanisms involved in inflammatory diseases. The present review summarizes the knowledge on the nociceptive and antinociceptive actions of sPLA2s from animal venoms, particularly snake venoms. View Full-Text
Keywords: secretory phospholipases A2; catalytic activity; animal venoms; pain; analgesia secretory phospholipases A2; catalytic activity; animal venoms; pain; analgesia
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Zambelli, V.O.; Picolo, G.; Fernandes, C.A.H.; Fontes, M.R.M.; Cury, Y. Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia. Toxins 2017, 9, 406.

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