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Toxins 2017, 9(12), 403;

Botulinum Toxin in the Field of Dermatology: Novel Indications

Department of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Author to whom correspondence should be addressed.
Academic Editor: Siro Luvisetto
Received: 20 November 2017 / Revised: 13 December 2017 / Accepted: 14 December 2017 / Published: 16 December 2017
Full-Text   |   PDF [251 KB, uploaded 16 December 2017]


Since its approval by the US Food and Drug Administration in 2002 for glabellar wrinkles, botulinum toxin (BTX) has been widely used to correct facial wrinkles. As a result, many consider BTX synonymous with cosmetic dermatology. Recent studies indicate that BTX elicits biological effects on various skin cell types via the modulation of neurotransmitter release, and it seems that BTX has a wider zone of dermatologic influence than originally understood. Clinicians and researchers are now beginning to explore the potential of BTX beyond the amelioration of facial lines and encouraging results are seen with BTX in a variety of skin conditions. In this paper, we review novel dermatological indications of BTX which includes (but not limited to) scar prevention, facial flushing, post-herpetic neuralgia and itch. These areas show great promise, but there is definite need for larger, double-blinded, randomized control trials against established treatments before BTX becomes a clinical reality. View Full-Text
Keywords: botulinum toxin; biological effect; various cell types; neurotransmitter; dermatology; novel indication botulinum toxin; biological effect; various cell types; neurotransmitter; dermatology; novel indication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kim, Y.S.; Hong, E.S.; Kim, H.S. Botulinum Toxin in the Field of Dermatology: Novel Indications. Toxins 2017, 9, 403.

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