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Toxins, Volume 15, Issue 4

April 2023 - 69 articles

Cover Story: The West African carpet viper (Echis ocellatus) was used in this study as a representative of medically significant Sub-Saharan African viperids. It is one of the species that exhibited a high level of proteolytic activity towards extracellular-matrix-mimicking polymers. Three toxins from the venom, all SVMPs (P-II and P-III), were identified as the active compounds. Overall, viperid venoms were significantly more active than elapid venoms, with E. ocellatus being the least active of the tested viperids. View this paper
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Articles (69)

  • Article
  • Open Access
3 Citations
4,147 Views
18 Pages

An Assassin’s Secret: Multifunctional Cytotoxic Compounds in the Predation Venom of the Assassin Bug Psytalla horrida (Reduviidae, Hemiptera)

  • Maike Laura Fischer,
  • Benjamin Fabian,
  • Yannick Pauchet,
  • Natalie Wielsch,
  • Silke Sachse,
  • Andreas Vilcinskas and
  • Heiko Vogel

20 April 2023

Predatory assassin bugs produce venomous saliva that enables them to overwhelm, kill, and pre-digest large prey animals. Venom from the posterior main gland (PMG) of the African assassin bug Psytalla horrida has strong cytotoxic effects, but the resp...

  • Article
  • Open Access
10 Citations
2,789 Views
15 Pages

Immunomodulatory Effects of Cylindrospermopsin in Human T Cells and Monocytes

  • Antonio Casas-Rodríguez,
  • Óscar Cebadero-Dominguez,
  • María Puerto,
  • Ana María Cameán and
  • Angeles Jos

20 April 2023

Cylindrospermopsin (CYN) is a cyanotoxin with an increasing occurrence, and therefore it is important to elucidate its toxicity profile. CYN has been classified as a cytotoxin, although the scientific literature has already revealed that it affects a...

  • Article
  • Open Access
12 Citations
3,154 Views
13 Pages

Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells

  • Tae Hong Kang,
  • Sangsu Shin,
  • JeongWoong Park,
  • Bo Ram Lee and
  • Sang In Lee

19 April 2023

Deoxynivalenol (DON) is known as a vomitoxin, which frequently contaminates feedstuffs, such as corn, wheat, and barley. Intake of DON-contaminated feed has been known to cause undesirable effects, including diarrhea, emesis, reduced feed intake, nut...

  • Article
  • Open Access
7 Citations
3,724 Views
53 Pages

Natural Antioxidant By-Product Mixture Counteracts the Effects of Aflatoxin B1 and Ochratoxin A Exposure of Piglets after Weaning: A Proteomic Survey on Liver Microsomal Fraction

  • Roua Gabriela Popescu,
  • George Cătălin Marinescu,
  • Andreea Luminița Rădulescu,
  • Daniela Eliza Marin,
  • Ionelia Țăranu and
  • Anca Dinischiotu

19 April 2023

Mycotoxins are toxic compounds produced by certain strains of fungi that can contaminate raw feed materials. Once ingested, even in small doses, they cause multiple health issues for animals and, downstream, for people consuming meat. It was proposed...

  • Article
  • Open Access
6 Citations
3,911 Views
15 Pages

Natriuretic-like Peptide Lebetin 2 Mediates M2 Macrophage Polarization in LPS-Activated RAW264.7 Cells in an IL-10-Dependent Manner

  • Dorsaf Bouzazi,
  • Wael Mami,
  • Amor Mosbah,
  • Naziha Marrakchi,
  • Melika Ben Ahmed and
  • Erij Messadi

19 April 2023

Snake natriuretic peptide (NP) Lebetin 2 (L2) has been shown to improve cardiac function and reduce fibrosis as well as inflammation by promoting M2-type macrophages in a reperfused myocardial infarction (MI) model. However, the inflammatory mechanis...

  • Article
  • Open Access
1 Citations
3,545 Views
14 Pages

Engineering BinB Pore-Forming Toxin for Selective Killing of Breast Cancer Cells

  • Tipaporn Kumkoon,
  • Chalongrat Noree and
  • Panadda Boonserm

18 April 2023

Breast cancer is one of the most common cancers in women worldwide. Conventional cancer chemotherapy always has adverse side effects on the patient’s healthy tissues. Consequently, combining pore-forming toxins with cell-targeting peptides (CTP...

  • Article
  • Open Access
6 Citations
10,624 Views
14 Pages

18 April 2023

The present study assessed muscular atrophy and weakness of the flexor digitorum superficialis (FDS) and profundus (FDP) muscle as possible long-term side effects of botulinum toxin (BoNT) injections in hand dystonia patients after the termination of...

  • Feature Paper
  • Article
  • Open Access
5 Citations
2,452 Views
18 Pages

18 April 2023

Mycotoxins are of great concern in relation to food safety. When animals are exposed to them, health problems, economic losses in farms and related industries, and the carryover of these compounds to animal-derived foods can occur. Therefore, control...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,023 Views
22 Pages

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

  • Eric Wachtel,
  • Matyas A. Bittenbinder,
  • Bas van de Velde,
  • Julien Slagboom,
  • Axel de Monts de Savasse,
  • Luis L. Alonso,
  • Nicholas R. Casewell,
  • Freek J. Vonk and
  • Jeroen Kool

18 April 2023

The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic...

  • Article
  • Open Access
35 Citations
3,359 Views
16 Pages

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

  • Shuidong Feng,
  • Mengyue Cao,
  • Peng Tang,
  • Shuxiang Deng,
  • Limou Chen,
  • Yan Tang,
  • Lemei Zhu,
  • Xiang Chen,
  • Zhijun Huang and
  • Minxue Shen
  • + 1 author

18 April 2023

Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs exposure and the risk of dyslipidemia a...

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Toxins - ISSN 2072-6651