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Toxins, Volume 15, Issue 5

May 2023 - 48 articles

Cover Story: T-2 toxin, deoxynivalenol, and fumonisin B1 are commonly found in poultry feed, leading to combined exposure. These mycotoxins have been associated with inducing oxidative stress, which the glutathione redox system neutralizes. In a short-term (3 days) in vivo study, the laying hens’ feed was contaminated with low (the individual EU-limiting doses) and high (twice the low dose) doses of the mycotoxins. The results showed that the multi-mycotoxin exposure in low doses increased the marker of lipid peroxidation and reduced glutathione content and glutathione peroxidase activity. This response can refer to ROS formation, resulting in lipid peroxidation formation and activation of the antioxidant system. Furthermore, these changes were observed when the EU-limiting doses were applied, which suggested synergistic toxicity interactions. View this paper
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Articles (48)

  • Article
  • Open Access
1 Citations
2,894 Views
21 Pages

Phylogeny-Related Variations in Venomics: A Test in a Subset of Habu Snakes (Protobothrops)

  • Hong-Yan Zhao,
  • Na He,
  • Yan Sun,
  • Yong-Chen Wang,
  • Hao-Bing Zhang,
  • Hui-Hui Chen,
  • Ya-Qi Zhang and
  • Jian-Fang Gao

21 May 2023

We conducted a comparative analysis to unveil the divergence among venoms from a subset of Old World habu snakes (Protobothrops) in terms of venomic profiles and toxicological and enzymatic activities. A total of 14 protein families were identified i...

  • Article
  • Open Access
5 Citations
2,659 Views
13 Pages

Bioactives Overproduction through Operational Strategies in the Ichthyotoxic Microalga Heterosigma akashiwo Culture

  • Adrián Macías-de la Rosa,
  • Miguel Ángel González-Cardoso,
  • María del Carmen Cerón-García,
  • Lorenzo López-Rosales,
  • Juan José Gallardo-Rodríguez,
  • Sergio Seoane,
  • Asterio Sánchez-Mirón and
  • Francisco García-Camacho

20 May 2023

The red tide-forming microalga Heterosigma akashiwo has been associated with massive events of fish deaths, both wild and cultured. Culture conditions are responsible for the synthesis or accumulation of some metabolites with different interesting bi...

  • Article
  • Open Access
10 Citations
2,762 Views
13 Pages

Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds

  • Alexandra G. Durán,
  • Nuria Chinchilla,
  • Ana M. Simonet,
  • M. Teresa Gutiérrez,
  • Jorge Bolívar,
  • Manuel M. Valdivia,
  • José M. G. Molinillo and
  • Francisco A. Macías

20 May 2023

Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of...

  • Article
  • Open Access
15 Citations
2,647 Views
18 Pages

The Potent Antitumor Activity of Smp43 against Non-Small-Cell Lung Cancer A549 Cells via Inducing Membranolysis and Mitochondrial Dysfunction

  • Ze Deng,
  • Yahua Gao,
  • Tienthanh Nguyen,
  • Jinwei Chai,
  • Jiena Wu,
  • Jiali Li,
  • Mohamed A. Abdel-Rahman,
  • Xueqing Xu and
  • Xin Chen

19 May 2023

Research has been conducted to investigate the potential application of scorpion venom-derived peptides in cancer therapy. Smp43, a cationic antimicrobial peptide from Scorpio maurus palmatus venom, has been found to exhibit suppressive activity agai...

  • Article
  • Open Access
3 Citations
3,120 Views
14 Pages

Antimicrobial Peptide Arsenal Predicted from the Venom Gland Transcriptome of the Tropical Trap-Jaw Ant Odontomachus chelifer

  • Josilene J. Menk,
  • Yan E. Matuhara,
  • Henrique Sebestyen-França,
  • Flávio Henrique-Silva,
  • Milene Ferro,
  • Renata S. Rodrigues and
  • Célio D. Santos-Júnior

18 May 2023

With about 13,000 known species, ants are the most abundant venomous insects. Their venom consists of polypeptides, enzymes, alkaloids, biogenic amines, formic acid, and hydrocarbons. In this study, we investigated, using in silico techniques, the pe...

  • Article
  • Open Access
1 Citations
2,452 Views
18 Pages

Effect of Monocerin, a Fungal Secondary Metabolite, on Endothelial Cells

  • Tainah Colombo Gomes,
  • Rafael Conrado,
  • Rodrigo Cardoso de Oliveira,
  • Priscila Jane Romano Gonçalves Selari,
  • Itamar Soares de Melo,
  • Welington Luiz Araújo,
  • Durvanei Augusto Maria and
  • Ana Olívia De Souza

18 May 2023

This study reports the isolation and identification of the endophytic fungus Exserohilum rostratum through molecular and morphological analysis using optical and transmission electron microscopy (TEM), as well as the procurement of its secondary meta...

  • Article
  • Open Access
2 Citations
2,217 Views
16 Pages

Behavioral and Physiological Alterations in Angus Steers Grazing Endophyte-Infected Toxic Fescue during Late Fall

  • Ignacio M. Llada,
  • Jeferson M. Lourenco,
  • Mikayla M. Dycus,
  • Jessica M. Carpenter,
  • Garret Suen,
  • Nicholas S. Hill and
  • Nikolay M. Filipov

18 May 2023

Fescue toxicosis is caused by grazing ergot alkaloid-producing endophyte (Epichloë coenophiala)-infected tall fescue (E+). Summer grazing of E+ leads to decreased productivity, associated impaired thermoregulation, and altered behavior. The goal...

  • Article
  • Open Access
22 Citations
11,070 Views
16 Pages

Neutralizing Antibody Formation with OnabotulinumtoxinA (BOTOX®) Treatment from Global Registration Studies across Multiple Indications: A Meta-Analysis

  • Joseph Jankovic,
  • Jean Carruthers,
  • Markus Naumann,
  • Patricia Ogilvie,
  • Terry Boodhoo,
  • Mayssa Attar,
  • Swati Gupta,
  • Ritu Singh,
  • John Soliman and
  • Irina Yushmanova
  • + 2 authors

17 May 2023

Though the formation of neutralizing antibodies (NAbs) during treatment with botulinum neurotoxin is rare, their presence may nonetheless affect the biological activity of botulinum toxin and negatively impact clinical response. The goal of this upda...

  • Article
  • Open Access
6 Citations
3,087 Views
20 Pages

Anxiolytic, Analgesic and Anti-Inflammatory Effects of Peptides Hmg 1b-2 and Hmg 1b-4 from the Sea Anemone Heteractis magnifica

  • Irina N. Gladkikh,
  • Anna A. Klimovich,
  • Rimma S. Kalina,
  • Yulia V. Kozhevnikova,
  • Timur A. Khasanov,
  • Dmitry I. Osmakov,
  • Sergey G. Koshelev,
  • Margarita M. Monastyrnaya,
  • Yaroslav A. Andreev and
  • Elena V. Leychenko
  • + 1 author

15 May 2023

Acid-sensing ion channels (ASICs) have been known as sensors of a local pH change within both physiological and pathological conditions. ASIC-targeting peptide toxins could be potent molecular tools for ASIC-manipulating in vitro, and for pathology t...

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Toxins - ISSN 2072-6651Creative Common CC BY license