You are currently viewing a new version of our website. To view the old version click .

Toxins, Volume 14, Issue 9

September 2022 - 71 articles

Cover Story: Sesquiterpenes and benzoxazinoids from natural sources were evaluated against the Mpro, RNA replicase and spike glycoprotein of SARS-CoV-2 using in silico approaches. These natural products and their derivatives have previously shown remarkable antiviral activities. The most relevant compounds were the 4-fluoro derivatives of santamarine, reynosin and 2-amino-3H-phenoxazin-3-one according to molecular docking. Those compounds fulfill oral bioavailability rules, and they displayed high compound-protein kinetic stability by molecular dynamics after a 50 ns simulation. Candidates tested in silico show that the addition of a 4-fluorobenzoate fragment to the natural products enhances their inhibition potential against the main protease, RNA replicase and spike protein of SARS-CoV-2. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (71)

  • Review
  • Open Access
50 Citations
8,674 Views
47 Pages

Mycotoxins Contamination in Rice: Analytical Methods, Occurrence and Detoxification Strategies

  • Ana Rita Santos,
  • Filipa Carreiró,
  • Andreia Freitas,
  • Sílvia Barros,
  • Carla Brites,
  • Fernando Ramos and
  • Ana Sanches Silva

19 September 2022

The prevalence of mycotoxins in the environment is associated with potential crop contamination, which results in an unavoidable increase in human exposure. Rice, being the second most consumed cereal worldwide, constitutes an important source of pot...

  • Article
  • Open Access
7 Citations
2,989 Views
14 Pages

Insecticidal Activity of Chitinases from Xenorhabdus nematophila HB310 and Its Relationship with the Toxin Complex

  • Jia Liu,
  • Hui Bai,
  • Ping Song,
  • Ziyan Nangong,
  • Zhiping Dong,
  • Zhiyong Li and
  • Qinying Wang

18 September 2022

Xenorhabdus nematophila HB310 secreted the insecticidal protein toxin complex (Tc). The chi60 and chi70 chitinase genes are located on the gene cluster encoding Tc toxins. To clarify the insecticidal activity of chitinases and their relationship with...

  • Feature Paper
  • Review
  • Open Access
41 Citations
6,965 Views
21 Pages

Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation

  • Avra Melina Madella,
  • Jeroen Van Bergenhenegouwen,
  • Johan Garssen,
  • Rosalinde Masereeuw and
  • Saskia Adriana Overbeek

18 September 2022

Uremic metabolites, molecules either produced by the host or from the microbiota population existing in the gastrointestinal tract that gets excreted by the kidneys into urine, have significant effects on both health and disease. Tryptophan-derived c...

  • Article
  • Open Access
11 Citations
3,573 Views
15 Pages

18 September 2022

Reports of bite from Protobothrops mucrosquamatus (Pmu) are frequent in Taiwan, and its wide-spread distribution and diverse habitats drove us to investigate its envenoming effects and relevant venom variations. We used reversed-phase high-performanc...

  • Article
  • Open Access
4 Citations
2,885 Views
24 Pages

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

  • Grazia Cottone,
  • Letizia Chiodo,
  • Luca Maragliano,
  • Michel-Robert Popoff,
  • Christine Rasetti-Escargueil,
  • Emmanuel Lemichez and
  • Thérèse E. Malliavin

17 September 2022

Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior of synaptic...

  • Article
  • Open Access
9 Citations
3,999 Views
10 Pages

Variation of Aflatoxin Levels in Stored Edible Seed and Oil Samples and Risk Assessment in the Local Population

  • Shahzad Zafar Iqbal,
  • Muhammad Waqas,
  • Ahmad Faizal Abdull Razis,
  • Sunusi Usman,
  • Nada Basheir Ali and
  • Muhammad Rafique Asi

17 September 2022

Five hundred and twenty samples of edible seeds and oilseeds (sunflower, palm, peanut, sesame, cotton, and grapeseed) were purchased from markets, farmers, and superstores in the central cities of Punjab, Pakistan. A total of 125 (48.1%) edible seed...

  • Article
  • Open Access
34 Citations
5,739 Views
14 Pages

Resveratrol Protects against Zearalenone-Induced Mitochondrial Defects during Porcine Oocyte Maturation via PINK1/Parkin-Mediated Mitophagy

  • Jiehuan Xu,
  • Lingwei Sun,
  • Mengqian He,
  • Shushan Zhang,
  • Jun Gao,
  • Caifeng Wu,
  • Defu Zhang and
  • Jianjun Dai

16 September 2022

Mitochondria hold redox homeostasis and energy metabolism as a crucial factor during oocyte maturation, while the exposure of estrogenic mycotoxin zearalenone causes developmental incapacity in porcine oocyte. This study aimed to reveal a potential r...

  • Article
  • Open Access
6 Citations
3,570 Views
16 Pages

16 September 2022

Frequent detection of mycotoxins ochratoxin A (OTA) and citrinin (CIT) in ruminant feed and feedstuff can be a potential threat to feed safety, animal performance and health. Ineffective biodegradation of these mycotoxins by rumen microflora followin...

  • Article
  • Open Access
7 Citations
2,869 Views
8 Pages

Analysis of the Roles of the ISLR2 Gene in Regulating the Toxicity of Zearalenone Exposure in Porcine Intestinal Epithelial Cells

  • Zhenbin Bi,
  • Xuezhu Gu,
  • Yeyi Xiao,
  • Yajing Zhou,
  • Wenbin Bao,
  • Shenglong Wu and
  • Haifei Wang

16 September 2022

Zearalenone (ZEN) is one of the mycotoxins that pose high risks for human and animal health, as well as food safety. However, the regulators involved in ZEN cellular toxicity remain largely unknown. Herein, we showed that cell viability of porcine in...

  • Article
  • Open Access
1 Citations
2,439 Views
12 Pages

15 September 2022

Cyanobacteria are a bloom-forming ancient group of photosynthetic prokaryotes. A rise in temperature is a major contributor to its massive proliferation, namely on freshwater ecosystems, with social and economic impacts. Thus, reliable and cost-effec...

of 8

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Toxins - ISSN 2072-6651