Table of Contents
Toxins, Volume 12, Issue 6 (June 2020) – 76 articles
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Cover Story (view full-size image) The venoms of Viperidae snakes are rich in proteins that strongly affect the haemostatic system. [...] Read more. The venoms of Viperidae snakes are rich in proteins that strongly affect the haemostatic system. This study describes the isolation, purification, and characterisation of an interesting procoagulant serine protease from the venom of the most venomous viper in Europe, Vipera ammodytes ammodytes (nose-horned viper). The blood coagulation-promoting effect of VaaSP-VX, as the glycoprotein was named, is most likely based on the simultaneous activation of blood coagulation factors V and X, precursors of the prothrombinase complex. A unique proteolytic specificity along with the resistance to serpin inhibition endow VaaSP-VX with promising medical potential, for example, in treating patients with haemophilia. View this paper