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Toxins, Volume 12, Issue 6

June 2020 - 76 articles

Cover Story: The venoms of Viperidae snakes are rich in proteins that strongly affect the haemostatic system. This study describes the isolation, purification, and characterisation of an interesting procoagulant serine protease from the venom of the most venomous viper in Europe, Vipera ammodytes ammodytes (nose-horned viper). The blood coagulation-promoting effect of VaaSP-VX, as the glycoprotein was named, is most likely based on the simultaneous activation of blood coagulation factors V and X, precursors of the prothrombinase complex. A unique proteolytic specificity along with the resistance to serpin inhibition endow VaaSP-VX with promising medical potential, for example, in treating patients with haemophilia. View this paper
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Articles (76)

  • Review
  • Open Access
14 Citations
7,125 Views
25 Pages

Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems

  • Chih-Han Tu,
  • Michelle Holt,
  • Shengfeng Ruan and
  • Christina Bourne

26 June 2020

The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same...

  • Article
  • Open Access
18 Citations
3,687 Views
19 Pages

Occurrence of Mycotoxins in Winter Rye Varieties Cultivated in Poland (2017–2019)

  • Robert Kosicki,
  • Magdalena Twarużek,
  • Paweł Dopierała,
  • Bartosz Rudzki and
  • Jan Grajewski

26 June 2020

Rye (Secale cereale L.) is one of the most important cereals and is used in both the food and feed industries. It is produced mainly in a belt extending from Russia through Poland to Germany. Despite the great economic importance of this cereal, ther...

  • Article
  • Open Access
11 Citations
3,570 Views
12 Pages

25 June 2020

The trichothecene mycotoxins contaminate cereal grains and have been related to alimentary toxicosis resulted in emetic response. This family of mycotoxins comprises type A to D groups of toxic sesquiterpene chemicals. Diacetoxyscirpenol (DAS), one o...

  • Article
  • Open Access
11 Citations
2,773 Views
11 Pages

25 June 2020

Patients with chronic kidney disease (CKD) have an increased risk of vascular calcification (VC), including aortic arch calcification (AAC). Few investigated the influence of gustatory function on the probability of having VC. We examined whether gus...

  • Article
  • Open Access
13 Citations
3,852 Views
22 Pages

25 June 2020

Zearalenone (ZEN) is a non-steroidal mycotoxin that has various toxicological impacts on mammalian health. Here, we found that ZEN significantly affected the production of nitric oxide (NO) and the expression of endothelial NO synthase (eNOS) of bovi...

  • Article
  • Open Access
5 Citations
3,128 Views
15 Pages

Analysis of Cry1Ah Toxin-Binding Reliability to Midgut Membrane Proteins of the Asian Corn Borer

  • Sivaprasath Prabu,
  • Muhammad Zeeshan Shabbir,
  • Zhenying Wang and
  • Kanglai He

24 June 2020

Evolution of insect resistance to Bt toxins challenges the use of Cry toxins to control agricultural pests. In lepidopterans, Cry toxin affinity towards multiple midgut epithelial receptors has become a matter of dispute. Cry1Ah toxin-binding protein...

  • Review
  • Open Access
35 Citations
4,880 Views
16 Pages

23 June 2020

Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are be...

  • Article
  • Open Access
7 Citations
4,313 Views
21 Pages

Metabolic Traits of Bovine Shiga Toxin-Producing Escherichia coli (STEC) Strains with Different Colonization Properties

  • Stefanie A. Barth,
  • Michael Weber,
  • Katharina Schaufler,
  • Christian Berens,
  • Lutz Geue and
  • Christian Menge

22 June 2020

Cattle harbor Shiga toxin-producing Escherichia coli (STEC) in their intestinal tract, thereby providing these microorganisms with an ecological niche, but without this colonization leading to any clinical signs. In a preceding study, genotypic chara...

  • Article
  • Open Access
19 Citations
3,612 Views
11 Pages

Biomonitoring of Enniatin B1 and Its Phase I Metabolites in Human Urine: First Large-Scale Study

  • Yelko Rodríguez-Carrasco,
  • Alfonso Narváez,
  • Luana Izzo,
  • Anna Gaspari,
  • Giulia Graziani and
  • Alberto Ritieni

22 June 2020

Enniatins (Enns) are mycotoxins produced by Fusarium spp. which are a fungus widely spread throughout cereals and cereal-based products. Among all the identified enniatins, Enn B1 stands as one of the most prevalent analogues in cereals in Europe. He...

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Toxins - ISSN 2072-6651