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Volume 15
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10.3390/nu15132944
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Article

Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats

by
Camelia Munteanu
1,
Mihaela Mihai
2,
Francisc Dulf
3,
Andreea Ona
1,*,
Leon Muntean
1,
Floricuța Ranga
4,
Camelia Urdă
5,
Daria Pop
6,
Tania Mihaiescu
3,
Sorin Marian Mârza
7,* and
Ionel Papuc
7
1
Department of Plant Culture, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
2
Department of Transversal Competencies, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
3
Department of Environmental and Plant Protection, Faculty of Agriculture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
4
Department of Food Science, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
5
Agricultural Research Development Station Turda, 27 Agriculturii Street, 401100 Turda, Romania
6
Clinic of Obstetrics and Gynecology II “Dominic Stanca”, University of Medicine and Pharmacy “Iuliu Hațieganu” Cluj-Napoca, Victor Babeș 8, 400347 Cluj-Napoca, Romania
7
Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Nutrients 2023, 15(13), 2944; https://doi.org/10.3390/nu15132944
Submission received: 26 May 2023 / Revised: 23 June 2023 / Accepted: 27 June 2023 / Published: 28 June 2023
(This article belongs to the Special Issue Diet Composition, Eating Habits and Their Impact on Metabolic Diseases)
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Abstract

The present pilot study investigates the blood biochemical changes induced by hemp seeds in rats with diabetes. The composition of industrial hemp seeds, antioxidant activity, identification and quantification of phenols and fatty acids from hemp oil were determined. The Wistar adult rats used in the experiment were divided into three groups (n = 6) and kept under standard conditions. Group one, the control group (individuals without diabetes), and group two (diabetic individuals) received water and normal food ad libitum, while the third group, also including diabetic individuals, received specific food (hemp seeds) and water ad libitum. Subsequent blood biochemical parameters were determined. Hemp seeds had higher phenol (14 compounds), flavonoids and PUFA contents compared to other plants seeds. In addition, the antioxidant activity in Cannabis sativa was also increased. Moreover, the ratio between n-6 and n-3 was 4.41, ideal for different diseases. Additionally, all biochemical parameters showed significant changes following the treatment. It was shown that high doses of hemp seeds decreased diabetes-induced biochemical damage in rats most probably due to the high content of active compounds. In order to use these seeds in humans, it is essential to find out which hemp compounds are particularly responsible for these effects. Moreover, for the objective investigation of their effects, longer-term studies are needed.
Keywords: cannabis; hydroxybenzoic acid; phenolic activity; fatty acids; glycemia cannabis; hydroxybenzoic acid; phenolic activity; fatty acids; glycemia

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MDPI and ACS Style

Munteanu, C.; Mihai, M.; Dulf, F.; Ona, A.; Muntean, L.; Ranga, F.; Urdă, C.; Pop, D.; Mihaiescu, T.; Mârza, S.M.; et al. Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats. Nutrients 2023, 15, 2944. https://doi.org/10.3390/nu15132944

AMA Style

Munteanu C, Mihai M, Dulf F, Ona A, Muntean L, Ranga F, Urdă C, Pop D, Mihaiescu T, Mârza SM, et al. Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats. Nutrients. 2023; 15(13):2944. https://doi.org/10.3390/nu15132944

Chicago/Turabian Style

Munteanu, Camelia, Mihaela Mihai, Francisc Dulf, Andreea Ona, Leon Muntean, Floricuța Ranga, Camelia Urdă, Daria Pop, Tania Mihaiescu, Sorin Marian Mârza, and et al. 2023. "Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats" Nutrients 15, no. 13: 2944. https://doi.org/10.3390/nu15132944

APA Style

Munteanu, C., Mihai, M., Dulf, F., Ona, A., Muntean, L., Ranga, F., Urdă, C., Pop, D., Mihaiescu, T., Mârza, S. M., & Papuc, I. (2023). Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats. Nutrients, 15(13), 2944. https://doi.org/10.3390/nu15132944

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