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Review

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

1
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
2
Department of Pharmacy, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
3
Department of Experimental Medicine, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
4
Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, CEINGE-Biotecnologie Avanzate, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Giampieri
Nutrients 2022, 14(3), 490; https://doi.org/10.3390/nu14030490
Received: 30 November 2021 / Revised: 16 January 2022 / Accepted: 20 January 2022 / Published: 23 January 2022
Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound. View Full-Text
Keywords: NLRP3 inflammasome; modulation activity; food; nutrients NLRP3 inflammasome; modulation activity; food; nutrients
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MDPI and ACS Style

Spano, M.; Di Matteo, G.; Ingallina, C.; Ambroselli, D.; Carradori, S.; Gallorini, M.; Giusti, A.M.; Salvo, A.; Grosso, M.; Mannina, L. Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation. Nutrients 2022, 14, 490. https://doi.org/10.3390/nu14030490

AMA Style

Spano M, Di Matteo G, Ingallina C, Ambroselli D, Carradori S, Gallorini M, Giusti AM, Salvo A, Grosso M, Mannina L. Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation. Nutrients. 2022; 14(3):490. https://doi.org/10.3390/nu14030490

Chicago/Turabian Style

Spano, Mattia, Giacomo Di Matteo, Cinzia Ingallina, Donatella Ambroselli, Simone Carradori, Marialucia Gallorini, Anna M. Giusti, Andrea Salvo, Michela Grosso, and Luisa Mannina. 2022. "Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation" Nutrients 14, no. 3: 490. https://doi.org/10.3390/nu14030490

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