Nutrients, Volume 10, Issue 1
2018 January - 110 articles
Cover Story: Inflammatory bowel disease (IBD) of which ulcerative colitis and Crohn’s disease are the two prevailing subtypes, is a chronic disorder with increasing worldwide incidence and prevalence rates affecting up to 0.5 % of the population in some countries. Anaemia due to iron deficiency is the most common extraintestinal manifestation among these patients. Chronic inflammation impairs duodenal iron uptake via induction of hepcidin expression in the liver, although pro-inflammatory cytokines also have a negative impact on the duodenal iron uptake. Additionally, loss of appetite during flaring disease along with certain medications used to control IBD might also have a negative influence on iron absorption. To overcome iron deficiency and resulting anaemia supplementation with either oral (cheap) or intravenous (costly and effective) iron may be useful therapeutic options. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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