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Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study

Program in Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, London SW7 1BU, UK
Barts and the London School of Medicine, Queen Mary University of London, London E1 1BZ, UK
Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
Upper Airway Research Laboratory, Ghent University, 9000 Ghent, Belgium
Research Unit of General Practice, Department of Public Health, University of Southern Denmark, 5000 Odense C; Denmark
Skin and Allergy Hospital, Helsinki University Hospital, 00029 HUS Helsinki, Finland
Deptartment of Pediatrics, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany
Institute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin, 10117 Berlin, Germany
Institute of Clinical Epidemiology and Biometry, Würzburg University, 97070 Würzburg, Germany
Department of Epidemiology, College of Medicine, Medical University of Silesia, 40-752 Katowice, Poland
Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 90-647 Lodz, Poland
Jagiellonian University School of Medicine, 31-008 Krakow, Poland
Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, 40-055 Katowice, Poland
Department of Immuno-Allergology, Coimbra University Hospital, 3000-075 Coimbra, Portugal
Division of ENT Diseases, Karolinska Institute, 171 77 Stockholm, Sweden
Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, 901 87 Umeå, Sweden
Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, 751 85 Uppsala, Sweden
Section of Occupational and Environmental Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden
Author to whom correspondence should be addressed.
Nutrients 2018, 10(1), 95;
Received: 4 December 2017 / Revised: 5 January 2018 / Accepted: 8 January 2018 / Published: 15 January 2018
(This article belongs to the Special Issue Effects of Polyphenol-Rich Foods on Human Health)
Background: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. Methods: A stratified random sample was drawn from the GA2LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV1/FVC), FVC below lower limit of normal (FVC < LLN), and FEV1/FVC < LLN were calculated. Intake of the six main subclasses of flavonoids was estimated using the GA2LEN Food Frequency Questionnaire. Adjusted associations between outcomes and each subclass of flavonoids were examined with multivariate regressions. Simes’ procedure was used to test for multiple comparisons. Results: A total of 2599 subjects had valid lung function and dietary data. A lower prevalence of FVC < LLN (airway restriction) was observed in those with higher total flavonoid (adjusted odds ratio (aOR), higher vs. lowest quintile intake 0.58; 95% Confidence Interval (CI) 0.36, 0.94), and pro-anthocyanidin intakes (aOR 0.47; 95% CI 0.27, 0.81). A higher FEV1/FVC was associated with higher intakes of total flavonoids and pro-anthocyanidins (adjusted correlation coefficient (a β-coeff 0.33; 0.10, 0.57 and a β-coeff 0.44; 95% CI 0.19, 0.69, respectively). After Simes’ procedure, the statistical significance of each of these associations was attenuated but remained below 0.05, with the exception of total flavonoids and airway restriction. Conclusions: This population-based study in European adults provides cross-sectional evidence of a positive association of total flavonoid intake and pro-anthocyanidins and ventilatory function, and a negative association with spirometric restriction in European adults. View Full-Text
Keywords: flavonoids; pro-anthocyanidins; lung function; GA2LEN flavonoids; pro-anthocyanidins; lung function; GA2LEN
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MDPI and ACS Style

Garcia-Larsen, V.; Thawer, N.; Charles, D.; Cassidy, A.; Van Zele, T.; Thilsing, T.; Ahlström, M.; Haahtela, T.; Keil, T.; Matricardi, P.M.; Brożek, G.; Kowalski, M.L.; Makowska, J.; Niżankowska-Mogilnicka, E.; Rymarczyk, B.; Loureiro, C.; Todo Bom, A.; Bachert, C.; Forsberg, B.; Janson, C.; Torén, K.; Potts, J.F.; Burney, P.G. Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study. Nutrients 2018, 10, 95.

AMA Style

Garcia-Larsen V, Thawer N, Charles D, Cassidy A, Van Zele T, Thilsing T, Ahlström M, Haahtela T, Keil T, Matricardi PM, Brożek G, Kowalski ML, Makowska J, Niżankowska-Mogilnicka E, Rymarczyk B, Loureiro C, Todo Bom A, Bachert C, Forsberg B, Janson C, Torén K, Potts JF, Burney PG. Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study. Nutrients. 2018; 10(1):95.

Chicago/Turabian Style

Garcia-Larsen, Vanessa, Narjis Thawer, David Charles, Aedin Cassidy, Thibaut Van Zele, Trine Thilsing, Matti Ahlström, Tari Haahtela, Thomas Keil, Paolo M Matricardi, Grzegorz Brożek, Marek L Kowalski, Joanna Makowska, Ewa Niżankowska-Mogilnicka, Barbara Rymarczyk, Carlos Loureiro, Ana Todo Bom, Claus Bachert, Bertil Forsberg, Christer Janson, Kjell Torén, James F Potts, and Peter GJ Burney. 2018. "Dietary Intake of Flavonoids and Ventilatory Function in European Adults: A GA2LEN Study" Nutrients 10, no. 1: 95.

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