Next Article in Journal
Coffee Intake and Liver Steatosis: A Population Study in a Mediterranean Area
Next Article in Special Issue
Assessment of Validity and Reproducibility of the Zinc-Specific Dietary Intake Questionnaire Conducted for Young Polish Female Respondents
Previous Article in Journal
Association between the Frequency of Protein-Rich Food Intakes and Kihon-Checklist Frailty Indices in Older Japanese Adults: The Kyoto-Kameoka Study
Previous Article in Special Issue
Prospective Study of Dietary Zinc Intake and Risk of Cardiovascular Disease in Women
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Nutrients 2018, 10(1), 88; https://doi.org/10.3390/nu10010088

Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease

1
Department of Medical Technology, Kagawa Prefectural University of Health Sciences, 281-1, Hara, Mure-Cho, Takamatsu, Kagawa 761-0123, Japan
2
Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0123, Japan
*
Author to whom correspondence should be addressed.
Received: 14 December 2017 / Revised: 4 January 2018 / Accepted: 5 January 2018 / Published: 14 January 2018
(This article belongs to the Special Issue Dietary Zn and Human Health)
Full-Text   |   PDF [703 KB, uploaded 14 January 2018]   |  

Abstract

Zinc (Zn) is an essential trace element which has favorable antioxidant, anti-inflammatory, and apoptotic effects. The liver mainly plays a crucial role in maintaining systemic Zn homeostasis. Therefore, the occurrence of chronic liver diseases, such as chronic hepatitis, liver cirrhosis, or fatty liver, results in the impairment of Zn metabolism, and subsequently Zn deficiency. Zn deficiency causes plenty of metabolic abnormalities, including insulin resistance, hepatic steatosis and hepatic encephalopathy. Inversely, metabolic abnormalities like hypoalbuminemia in patients with liver cirrhosis often result in Zn deficiency. Recent studies have revealed the putative mechanisms by which Zn deficiency evokes a variety of metabolic abnormalities in chronic liver disease. Zn supplementation has shown beneficial effects on such metabolic abnormalities in experimental models and actual patients with chronic liver disease. This review summarizes the pathogenesis of metabolic abnormalities deriving from Zn deficiency and the favorable effects of Zn administration in patients with chronic liver disease. In addition, we also highlight the interactions between Zn and other trace elements, vitamins, amino acids, or hormones in such patients. View Full-Text
Keywords: zinc deficiency; HCV-related chronic liver disease; nonalcoholic steatohepatitis; liver cirrhosis; insulin resistance; hepatic steatosis; hepatic encephalopathy; iron overload; lipid peroxidation; insulin-like growth factor-1 zinc deficiency; HCV-related chronic liver disease; nonalcoholic steatohepatitis; liver cirrhosis; insulin resistance; hepatic steatosis; hepatic encephalopathy; iron overload; lipid peroxidation; insulin-like growth factor-1
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Himoto, T.; Masaki, T. Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. Nutrients 2018, 10, 88.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top