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Neurology International, Volume 16, Issue 4

2024 August - 16 articles

Cover Story: The following study explores the possibility that dysregulated sphingosine-1-phosphate (S1P) metabolism affects Alzheimer’s disease (AD) through altered function in glial cells. Sphingosine kinase (SK) 1 inhibition by PF-543 decreases S1P content and augments LPS-induced inflammatory responses in both astrocytes and microglia. Decreased S1P affects the microglial inflammatory responses through humoral factors from astrocytes. PF-543 also decreases microglial Aβ uptake and increases the number of injured neurons, resulting in Aβ accumulation and ultimately neuronal loss in the Aβ-treated neuron/glia mixed culture. The results indicate that a decrease in glial S1P content can exacerbate neuroinflammation and neurodegeneration through altered glial cell functions. View this paper
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Articles (16)

  • Article
  • Open Access
1 Citations
5,395 Views
11 Pages

21 August 2024

Population-based data on drug-resistant epilepsy (DRE) are lacking. This retrospective study aimed to determine the prevalence and incidence of pediatric epilepsy and DRE in South Korea using health insurance claims data from the Health Insurance Rev...

  • Case Report
  • Open Access
4 Citations
5,079 Views
11 Pages

Clinical Case of a 23-Year-Old Patient with Moyamoya Disease and Epilepsy in Bulgaria

  • Ekaterina Viteva,
  • Petar Vasilev,
  • Georgi Vasilev and
  • Kostadin Chompalov

20 August 2024

Moyamoya disease is a cerebrovascular pathology characterized by progressive stenosis of the internal carotid arteries and their branches, leading to ischemic and/or hemorrhagic disorders of the cerebral circulation, primarily affecting children and...

  • Article
  • Open Access
3 Citations
2,304 Views
16 Pages

16 August 2024

Objective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, and to explore a possible association with clinical symptoms, emotional disturbance and disease severity. Methods: This single-center longitu...

  • Article
  • Open Access
2 Citations
2,537 Views
8 Pages

Post-Traumatic Epilepsy: Observations from an Urban Level 1 Trauma Center

  • Daniel Kotas,
  • Huaqing Zhao,
  • John Turella and
  • Willard S. Kasoff

5 August 2024

There are approximately 2.5 million cases of traumatic brain injury (TBI) in the U.S. each year. Post-traumatic epilepsy (PTE), a sequela of TBI, has been shown to occur in approximately 15% of TBI patients. Pre-disposing risk factors for the develop...

  • Article
  • Open Access
1 Citations
2,116 Views
12 Pages

Precision Dopaminergic Treatment in a Cohort of Parkinson’s Disease Patients Carrying Autosomal Recessive Gene Variants: Clinical Cohort Data and a Mini Review

  • Christos Koros,
  • Athina-Maria Simitsi,
  • Nikolaos Papagiannakis,
  • Anastasia Bougea,
  • Roubina Antonelou,
  • Ioanna Pachi,
  • Evangelos Sfikas,
  • Evangelia Stanitsa,
  • Efthalia Angelopoulou and
  • Leonidas Stefanis
  • + 4 authors

30 July 2024

Introduction: Parkinson’s disease (PD) patients harboring recessive gene variants exhibit a distinct clinical phenotype with an early disease onset and relatively mild symptoms. Data concerning individualized therapy for autosomal recessive PD...

  • Article
  • Open Access
1 Citations
2,737 Views
12 Pages

29 July 2024

High blood pressure (BP) and cerebral amyloid angiopathy (CAA) are two common risk factors for intracranial hemorrhage, potentially leading to cognitive impairment. Less is known about the relationship between BP and CAA, the examination of which was...

  • Perspective
  • Open Access
22 Citations
11,030 Views
16 Pages

29 July 2024

Animal experimentation has long been a cornerstone of neurology research, but it faces growing scientific, ethical, and economic challenges. Advances in artificial intelligence (AI) are providing new opportunities to replace animal testing with more...

  • Article
  • Open Access
2 Citations
1,945 Views
14 Pages

Multiple Administration of Dexamethasone Possesses a Deferred Long-Term Effect to Glycosylated Components of Mouse Brain

  • Stanislav D. Aladev,
  • Dmitry K. Sokolov,
  • Anastasia V. Strokotova,
  • Galina M. Kazanskaya,
  • Alexander M. Volkov,
  • Svetlana V. Aidagulova and
  • Elvira V. Grigorieva

22 July 2024

Glucocorticoids are used during glioblastoma treatment to prevent the cerebral edema effect surrounding normal brain tissue. The aim of our study was to investigate the long-term effects of multiple administrations of glucocorticoids onto the glycosy...

  • Review
  • Open Access
4 Citations
2,668 Views
14 Pages

18 July 2024

The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in a variety of models of peripheral illnesses, with little clarification on their interaction within...

  • Article
  • Open Access
1 Citations
4,179 Views
15 Pages

Efficacy and Safety of Rescue Treatment with Plasma Exchange in Patients with Acute Inflammatory Neurological Disorders: A Single Center Experience

  • Salvatore Iacono,
  • Giuseppe Schirò,
  • Giuseppe Salemi,
  • Elisabetta Scirè,
  • Paolo Aridon,
  • Michele Melfa,
  • Michele Andolina,
  • Gabriele Sorbello,
  • Andrea Calì and
  • Paolo Ragonese
  • + 2 authors

10 July 2024

Background: Therapeutic plasma exchange (TPE) is a highly effective rescue treatment for patients with acute exacerbation of neuroimmunological disease that removes circulating autoantibodies and inflammatory components from the bloodstream. The aims...

  • Review
  • Open Access
12 Citations
8,600 Views
30 Pages

Molecular and Biochemical Therapeutic Strategies for Duchenne Muscular Dystrophy

  • Lakshmi Krishna,
  • Akila Prashant,
  • Yogish H. Kumar,
  • Shasthara Paneyala,
  • Siddaramappa J. Patil,
  • Shobha Chikkavaddaragudi Ramachandra and
  • Prashant Vishwanath

Significant progress has been achieved in understanding Duchenne muscular dystrophy (DMD) mechanisms and developing treatments to slow disease progression. This review article thoroughly assesses primary and secondary DMD therapies, focusing on innov...

  • Article
  • Open Access
1 Citations
1,880 Views
22 Pages

In Alzheimer’s disease (AD) pathology, the accumulation of amyloid-beta (Aβ), a main component of senile plaques, activates glial cells and causes neuroinflammation. Excessive neuroinflammation results in neuronal dropouts and finally prod...

  • Case Report
  • Open Access
3,543 Views
8 Pages

28 June 2024

The pathology of idiopathic intracranial hypertension (IIH), a disease characterized by papillary edema and increased intracranial pressure (IICP), is not yet understood; this disease significantly affects quality of life due to symptoms including vi...

  • Article
  • Open Access
2 Citations
2,252 Views
12 Pages

The Effect of Repetitive Transcranial Magnetic Stimulation on Cognition in Diffuse Axonal Injury in a Rat Model

  • Hyeong-Min Kim,
  • Hyun-Seok Jo,
  • Eun-Jong Kim,
  • Ji-Min Na,
  • Hyeng-Kyu Park,
  • Jae-Young Han,
  • Ki-Hong Kim,
  • Insung Choi and
  • Min-Keun Song

25 June 2024

Diffuse axonal injury (DAI) following sudden acceleration and deceleration can lead to cognitive function decline. Various treatments have been proposed. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive stimulation technique, is a...

  • Article
  • Open Access
5 Citations
3,244 Views
16 Pages

Effects of Anti-CGRP Monoclonal Antibodies on Neurophysiological and Clinical Outcomes: A Combined Transcranial Magnetic Stimulation and Algometer Study

  • Paolo Manganotti,
  • Manuela Deodato,
  • Laura D’Acunto,
  • Francesco Biaduzzini,
  • Gabriele Garascia and
  • Antonio Granato

22 June 2024

Background: the aim of this study was to investigate the neurophysiological effect of anti-CGRP monoclonal antibodies on central and peripheral levels in migraine patients. Methods: An observational cohort study in patients with migraine was performe...

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Neurol. Int. - ISSN 2035-8377