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Neurology International, Volume 16, Issue 3

June 2024 - 16 articles

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Cover Story: Parkinson’s disease (PD), one of the main neurological disorders associated with Lewy bodies and the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), continues to pose significant challenges in the field of neurology. The underlying mechanisms of PD are unclear, but oxidative stress and antioxidant imbalance play a crucial role in the onset and progression of this disorder. In this context, compounds like Vitamin E, Creatine, CoQ10, MitoQ, Quercetin and bioactive molecules have been described as novel therapeutic strategies to prevent and treat the condition. These compounds often have antioxidant properties, which can help mitigate the oxidative stress associated with PD. View this paper

Articles (16)

  • Article
  • Open Access
1 Citations
1,480 Views
10 Pages

Anesthesia for Endovascular Therapy for Stroke

  • Arianna Gaspari,
  • Giulia Vaccari,
  • Federica Arturi,
  • Gabriele Melegari and
  • Stefano Baroni

20 June 2024

Background: In patients with acute ischemic stroke, the standard of care is to perform intra-arterial endovascular thrombectomy in addition to intravenous thrombolysis. In this study, we investigated the different anesthetic techniques chosen for thi...

  • Brief Report
  • Open Access
1 Citations
2,061 Views
10 Pages

11 June 2024

The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules. Here, we examined the relationship between neuronal depolarizat...

  • Article
  • Open Access
2 Citations
3,801 Views
10 Pages

The combined use of lasmiditan and triptan is unexplored in medical literature. This study aimed to investigate whether the intake of lasmiditan following triptan improves migraine pain. Following triptan intake, if headache relief was less than 50%...

  • Article
  • Open Access
5 Citations
3,551 Views
12 Pages

Nusinersen Treatment for Spinal Muscular Atrophy: Retrospective Multicenter Study of Pediatric and Adult Patients in Kuwait

  • Asma AlTawari,
  • Mohammad Zakaria,
  • Walaa A. Kamel,
  • Nayera Shaalan,
  • Gamal Ahmed Ismail Elghazawi,
  • Mohamed Esmat Anwar Ali,
  • Dalia Salota,
  • Amr Attia,
  • Ehab Elsayed Ali Elanany and
  • Osama Shalaby
  • + 3 authors

Spinal muscular atrophy is a neuromuscular genetic condition associated with progressive muscle weakness and atrophy. Nusinersen is an antisense oligonucleotide therapy approved for the treatment of 5q spinal muscular atrophy in pediatric and adult p...

  • Article
  • Open Access
1,873 Views
11 Pages

Communicating Arteries and Leptomeningeal Collaterals: A Synergistic but Independent Effect on Patient Outcomes after Stroke

  • Sara Sablić,
  • Krešimir Dolić,
  • Danijela Budimir Mršić,
  • Mate Čičmir-Vestić,
  • Antonela Matana,
  • Sanja Lovrić Kojundžić and
  • Maja Marinović Guić

The collateral system is a compensatory mechanism activated in the acute phase of an ischemic stroke. It increases brain perfusion to the hypoperfused area. Arteries of the Willis’ circle supply antegrade blood flow, while pial (leptomeningeal)...

  • Article
  • Open Access
7 Citations
2,635 Views
15 Pages

Objective: This study aims to develop and validate the Futile Recanalization Prediction Score (FRPS), a novel tool designed to predict the severity risk of FR and aid in pre- and post-EVT risk assessments. Methods: The FRPS was developed using a rigo...

  • Article
  • Open Access
1 Citations
3,761 Views
15 Pages

Outcome after Intracerebral Haemorrhage and Decompressive Craniectomy in Older Adults

  • Thomas Kapapa,
  • Stefanie Jesuthasan,
  • Frederike Schiller,
  • Franziska Schiller,
  • Marcel Oehmichen,
  • Dieter Woischneck,
  • Benjamin Mayer and
  • Andrej Pala

Objective: There is a relationship between the incidence of spontaneous intracerebral haemorrhage (ICH) and age. The incidence increases with age. This study aims to facilitate the decision-making process in the treatment of ICH. It therefore investi...

  • Review
  • Open Access
9 Citations
2,611 Views
23 Pages

The Effectiveness of Paired Associative Stimulation on Motor Recovery after Stroke: A Scoping Review

  • Andrea Baroni,
  • Annibale Antonioni,
  • Giulia Fregna,
  • Nicola Lamberti,
  • Fabio Manfredini,
  • Giacomo Koch,
  • Alessandro D’Ausilio and
  • Sofia Straudi

Paired associative stimulation (PAS) is a non-invasive brain stimulation technique combining transcranial magnetic stimulation and peripheral nerve stimulation. PAS allows connections between cortical areas and peripheral nerves (C/P PAS) or between...

  • Case Report
  • Open Access
2 Citations
2,028 Views
6 Pages

Supranuclear Palsy as an Initial Presentation of the Adult-Onset Niemann-Pick Type C

  • Ali A. Mohamed,
  • Willy Gan,
  • Denis Babici,
  • Veronica Hagan,
  • Raphael Wald and
  • Marc Swerdloff

(1) Background: Niemann–Pick type C1 (NP-C1) is a lysosomal storage disorder that results in the defective trafficking of cholesterol and other cellular lipids in the endosomal–lysosomal pathway. This rare autosomal recessive disorder pre...

  • Article
  • Open Access
1,472 Views
10 Pages

The Usefulness of Factor XIII Concentration Assessment in Patients in the Acute Phase of Ischaemic Stroke Treated with Thrombolysis

  • Małgorzata Wiszniewska,
  • Urszula Włodarczyk,
  • Magdalena Sury,
  • Artur Słomka,
  • Natalia Piekuś-Słomka,
  • Anna Żdanowicz and
  • Ewa Żekanowska

Background and Aims: In recent years, there has been a growing interest in factor XIII in ischaemic stroke. The study’s main aim was to assess the usefulness of factor XIII concentration determination in patients with acute ischaemic stroke (AI...

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